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Results for "

WRN

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) ATM/ATR (1) DNA/RNA Synthesis (45) PAK (1) Phosphatase (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (44)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148699

HRO761 3 Publications Verification Werner syndrome RecQ helicase-IN-1	DNA/RNA Synthesis	Cancer
HRO761 (Werner syndrome RecQ helicase-IN-1) (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .

HY-158116

VVD-214 RO7589831; VVD-133214	DNA/RNA Synthesis	Cancer
VVD-214 is a synthetic lethal allosteric inhibitor of *WRN* helicase with an IC₅₀ of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers .

HY-169422

GSK4418959 IDE275	DNA/RNA Synthesis	Cancer
GSK4418959 (IDE275) is a selective, reversible and orally active WRN helicase inhibitor. GSK4418959 shows >10,000-fold selectivity over other helicases. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer, such as colorectal cancer (CRC) and endometrial cancer (EC) .

HY-12342

ML216 Maximum Cited Publications 7 Publications Verification CID-49852229	DNA/RNA Synthesis	Cancer
ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC₅₀s of 2.98 μM and 0.97 μM for BLM ^full-length and BLM ^636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a K_i of 1.76 μM. Antitumor avtivity .

HY-110185

NSC 617145 3 Publications Verification	DNA/RNA Synthesis	Cancer
NSC 617145 is a selective *werner syndrome helicase (WRN) helicase* inhibitor with an IC₅₀ value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .

HY-175750

MOMA-341	DNA/RNA Synthesis	Cancer
MOMA-341 is a selective Werner RecQ like helicase (WRN) inhibitor. MOMA-341 binds to WRN at cysteine 727 through an allosteric and ATP-competitive binding mechanism. MOMA-341 has antitumor activity and can be used for advanced and metastatic solid tumors research .

HY-148740

Werner syndrome RecQ helicase-IN-3	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC₅₀ value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity .

HY-163942

GSK_WRN4	DNA/RNA Synthesis	Cancer
GSK_WRN4 is an orally active *WRN* helicase inhibitor (pIC₅₀=7.6). GSK_WRN4 induces DNA damage markers (p21, p-γH2AX, p-KAP1). GSK_WRN4 selectively inhibits microsatellite-unstable tumor growth in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and regions of DNA damage .

HY-162471

GSK_WRN3	DNA/RNA Synthesis ATM/ATR	Cancer
GSK_WRN3 is selective WRN helicase inhibitor (pIC₅₀ = 8.6). SK_WRN3 can selectively inhibit the growth of microsatellite unstable (MSI) cancer cells, induce DNA damage, and cause cell cycle arrest. GSK_WRN3 has anti-tumor activity .

HY-160859

WRN inhibitor 8	DNA/RNA Synthesis	Cancer
WRN inhibitor 8 is an inhibitor of WRN helicase with an IC₅₀ value of 48 nM. WRN inhibitor 8 can inhibit the proliferation of tumor cells and be used in the study of cancer .

HY-128712

NCGC00029283	DNA/RNA Synthesis	Cancer
NCGC00029283 is a *werner syndrome helicase-nuclease (WRN) helicase* inhibitor with IC₅₀s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively .

HY-169422A

GSK4418959 (enantiomer) IDE275 (enantiomer)	DNA/RNA Synthesis	Cancer
GSK4418959 enantiomer is an enantiomer of GSK4418959 (HY-169422). GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer .

HY-156580

WRN inhibitor 4	DNA/RNA Synthesis	Cancer
WRN inhibitor 4 is a Werner Syndrome ATP-dependent helicase (WRN) inhibitor. WRN inhibitor 4 can be used for cancer research .

HY-148741

Werner syndrome RecQ helicase-IN-4	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC₅₀ value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity .

HY-153692

WRN inhibitor 1	DNA/RNA Synthesis	Cancer
WRN inhibitor 1 is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor that inhibits *WRN* helicase domain activity. WRN inhibitor 1 can be used in the study of cancer .

HY-156579

WRN inhibitor 3	DNA/RNA Synthesis	Cancer
WRN inhibitor 3 (example 110), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme *(WRN)* inhibitor. WRN inhibitor 3 can be used for the research of cancer .

HY-156581

WRN inhibitor 5	DNA/RNA Synthesis	Cancer
WRN inhibitor 5, a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 5 can be used for the research of cancer, including cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair system (dMMR) .

HY-148700

Werner syndrome RecQ helicase-IN-2	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .

HY-168592

WRN inhibitor 12	DNA/RNA Synthesis	Cancer
WRN inhibitor 12 (compound 5) is an inhibitor of WRN helicase .

HY-169423

WRN inhibitor 17	DNA/RNA Synthesis	Cancer
WRN inhibitor 17 (Compound 250) is an orally active Werner Syndrome ATP dependent helicase enzyme (WRN) inhibitor, in particular inhibit *WRN* helicase domain activity. WRN inhibitor 17 is promising for research of cancers .

HY-174217

WRN-IN-19	DNA/RNA Synthesis	Cancer
WRN-IN-19 (Compound (S)-27) is a covalent WRN helicase inhibitor, with pIC50 (0 h/4 h) = 5.4/7.5 in the DNA-unwinding 5 endpoint assays. WRN-IN-19 shows synthetic lethality in MSI-H (high microsatellite instability) cancer cells .

HY-178474

WRN-IN-20	DNA/RNA Synthesis Apoptosis	Cancer
WRN inhibitor 20 (Compound 14c) is a *WRN* degradation agent. WRN inhibitor 20 exhibits strong degradation activity in various cells, such as HCT-116 (DC₅₀ = 1.7 µM), SW-48 (DC₅₀ = 3.0 µM), and SW-480 (DC₅₀ = 5.9 µM) cells. WRN inhibitor 20 exhibits potent anti proliferative, pro apoptotic, migration inhibiting, and DNA damage inducing effects in MSI-H cells. WRN inhibitor 20 can be used for research on cancer .

HY-178991

WRN-IN-21	DNA/RNA Synthesis	Cancer
WRN-IN-21 (Compound 11b) is a WRN helicase inhibitor with pIC₅₀ values for *WRN* and BLM helicases of 3.6 and 5.4 respectively. WRN-IN-21 can be used for the study of MSI-related cancers .

HY-149887

H3B-968 1 Publications Verification	DNA/RNA Synthesis	Cancer
H3B-968 is the ATP-competitive inhibitor of Werner syndrome protein (WRN) with an IC₅₀ of about 10 nM .

HY-153692A

*(R)-WRN* inhibitor 1**	DNA/RNA Synthesis	Cancer
(R)-WRN inhibitor 1 is the R-isomer of WRN inhibitor 1 (example 7). WRN inhibitor 1 is a *WRN* inhibitor with anticancer activity .

HY-161386

WRN inhibitor 7	DNA/RNA Synthesis	Cancer
WRN inhibitor 7 (Compound h6) is a *WRN* inhibitor. WRN inhibitor 7 effectively inhibits WRN's helicase and ATPase activity (IC₅₀: 9.8 μM and 15.8 μM respectively). WRN inhibitor 7 can be used for research of microsatellite instable (MSI) cancers .

HY-153973

WRN inhibitor 2	DNA/RNA Synthesis	Cancer
WRN inhibitor 2 (example 118) is a *WRN* (Werner Syndrome ATP dependent helicase enzyme) inhibitor, with pIC₅₀ ≥ 7.0 .

HY-164852

WRN inhibitor 13	DNA/RNA Synthesis	Others
WRN inhibitor 13 is a WRN helicase inhibitor with a pIC₅₀ of 6-7 .

HY-163941

GSK_WRN2	DNA/RNA Synthesis	Cancer
GSK_WRN2 is a potent and selective covalent WRN helicase inhibitor that suppresses replication stress caused by DNA (TA)_n dinucleotide repeat expansions. GSK_WRN2 can be used to study microsatellite instability (MSI) cancers .

HY-176912

WRN-IN-22	DNA/RNA Synthesis	Cancer
WRN-IN-22 (compound A01) is a potent Werner syndrome RecQ helicase (WRN) inhibitor (IC₅₀ < 100 nM). WRN-IN-22 can be used for microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) cancer research, such as colorectal, gastric, prostate and endometrial cancer .

HY-169414

WRN inhibitor 15	DNA/RNA Synthesis	Cancer
WRN inhibitor 15 (Compound 9) is a *WRN* inhibitor with anti-tumor activity that can be used in prostate cancer research, the IC₅₀ values are 37.9, 40.2 and 46.6 μM in PC3, LNCaP, and HeLa .

HY-168934

KWR137	DNA/RNA Synthesis	Cancer
KWR137 is a *WRN* degrader, with an IC₅₀ of 8 nM. KWR137 exhibits good anti-proliferative activity against MSI-H cells, with a GI₅₀ of 509 nM in SW48 cells and a GI₅₀ of 824 μM in HCT116 cells. It also demonstrates anti-tumor growth effects in xenograft mouse models. KWR137 can be used for cancer research .

HY-176727

WRN inhibitor 19	DNA/RNA Synthesis	Cancer
WRN inhibitor 19 (Compound 40) is a *WRN* helicase inhibitor (IC₅₀: 3.7 nM). WRN inhibitor 19 exhibits selective antiproliferative activity in WRN-dependent cancer cells. WRN inhibitor 19 inhibits WRN helicase function by competitively binding to the ATP site and induces DNA damage and cell cycle arrest. WRN inhibitor 19 can be used in the study of WRN-dependent cancers .

HY-157954

WRN inhibitor 6	DNA/RNA Synthesis Apoptosis	Cancer
WRN inhibitor 6 (compound 3ci) is a potent *WRN* inhibitor. WRN inhibitor 6 induces apoptosis. WRN inhibitor 6 increases the expression of p-p53, P-Chk2, γH2AX expression .

HY-163797

WRN inhibitor 10	DNA/RNA Synthesis	Cancer
WRN inhibitor 10 (Compound P24) is an inhibitor for the Werner helicase *WRN* with an IC₅₀ of 1.1 nM. WRN inhibitor 10 inhibits the proliferation of cancer cell SW48 with IC₅₀ of 39 nM. WRN inhibitor 10 exhibits good liver microsomal stability and film permeability. WRN inhibitor 10 exhibits good pharmacokinetic characteristics in CD-1 mice .

HY-168583

WRN inhibitor 11	DNA/RNA Synthesis	Cancer
WRN inhibitor 11 (Example 17) is an orally active inhibitor of WRN helicase, with the IC₅₀ of 63 nM .

HY-169424

WRN inhibitor 18	DNA/RNA Synthesis	Cancer
WRN inhibitor 18 (compound 306) is an orally available inhibitor of WRN with in vivo anticancer activity .

HY-169928

WRN inhibitor 14	DNA/RNA Synthesis	Cancer
WRN inhibitor 14 (compound S35) is an orally active *WRN* inhibitor with anticancer activity. WRN inhibitor 14 results in tumor growth inhibition in the SW48 xenograft model in BALB/c nude mice .

HY-RS22970

Wrn Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Wrn Rat Pre-designed siRNA Set A contains three designed siRNAs for Wrn gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Wrn Rat Pre-designed siRNA Set A Wrn Rat Pre-designed siRNA Set A

HY-RS15847

WRN Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
WRN Human Pre-designed siRNA Set A contains three designed siRNAs for WRN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

WRN Human Pre-designed siRNA Set A WRN Human Pre-designed siRNA Set A

HY-158025

Anticancer agent 198	DNA/RNA Synthesis	Cancer
Anticancer agent 198 (compound 18b) is a potent anticancer agent and potential *WRN* protein inhibitor. Anticancer agent 198 was significantly toxic to K562 cells and WRN-overexpressing PC3 cells .

HY-168933

KWR095	DNA/RNA Synthesis	Cancer
KWR095 is an orally active *WRN* inhibitor with an IC₅₀ of 0.032 μM for WRN ATPase. KWR095 can impede the duplex unwinding activity of *WRN* and inhibit the proliferation of tumor cells. KWR095 has anti-tumor activity .

HY-182313

WRN-IN-25	DNA/RNA Synthesis	Cancer
WRN-IN-25 is an allosteric Werner syndrome helicase (WRN) inhibitor with an IC₅₀ of 15 nM and a K_d of 54 nM. WRN-IN-25 induces DNA damage, reduces cell viability, and exhibits synthetic lethality in *WRN*-driven high microsatellite instability cancer cells. WRN-IN-25 can be used in research related to microsatellite instability cancers .

HY-183610

WRN-IN-26	DNA/RNA Synthesis PAK	Cancer
WRN-IN-26 is an orally active Werner syndrome helicase (WRN) inhibitor with a human K_i value of 58.7 μM and an IC₅₀ value of 0.026 μM. WRN-IN-26 selectively targets the cysteine residues of WRN. WRN-IN-26 induces the expression of p21 protein in MSI-H tumor cells. WRN-IN-26 inhibits the growth of MSI-H tumor cells and exhibits potent in vivo efficacy in MSI-H xenograft tumor models. WRN-IN-26 can be used for the research of microsatellite instability-high (MSI-H) cancers .

HY-179326

WRN-IN-23	DNA/RNA Synthesis	Cancer
WRN-IN-23 is a Werner Syndrome helicase enzyme (WRN) inhibitor. WRN-IN-23 inhibits the ATP-dependent helicase domain activity of WRN. WRN-IN-23 can be used for the research of cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair system (dMMR) .

HY-181562

WRN-IN-24	DNA/RNA Synthesis	Cancer
WRN-IN-24 is an orally active allosteric covalent Werner syndrome helicase (WRN) inhibitor with an IC₅₀ of 201 nM. WRN-IN-24 binds to a novel allosteric cavity, forms an additional hydrogen bond with K894, and functionally inhibits WRN activity. WRN-IN-24 inhibits colorectal cancer cells proliferation and exerts dose-dependent antitumor activity in xenograft mouse models. WRN-IN-24 can be used for the research of microsatellite instability-high cancers, including colorectal cancer .

HY-RS16538

Wrn Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Wrn Mouse Pre-designed siRNA Set A contains three designed siRNAs for Wrn gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Wrn Mouse Pre-designed siRNA Set A Wrn Mouse Pre-designed siRNA Set A

HY-182634

NCGC00063279	DNA/RNA Synthesis Phosphatase	Cancer
NCGC00063279 is a reversible Werner Syndrome Helicase-Nuclease (WRN) helicase inhibitor with modest selectivity over BLM and FANCJ helicases, and does not inhibit WRN exonuclease activity at active concentrations. NCGC00063279 inhibits Hematopoietic Protein Tyrosine Phosphatase (HePTP) and reduces proliferation of cancer cells. NCGC00063279 can be used for the research of osteosarcoma .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704738

	WRN Protein, Human (His) Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; WRN; DNA helicase; RecQ-like type 3; RecQ protein-like 2; Werner syndrome protein; RECQ3; RECQL2	Human	E. coli
	WRN Protein, Human (His) is the recombinant human-derived WRN protein, expressed by E. coli, with N-His tag.

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HY-P82276

	WRN Antibody (YA2021) Exonuclease WRN; RecQ3; RECQL2; RECQL3; Werner syndrome helicase; WRN	WB	Human
	WRN Antibody (YA2021) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WRN.

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