134 Results for "

Xanthone

" in MedChemExpress (MCE) Product Catalog:
Products (134)

134 Results for "Xanthone" in MCE Product Catalog:

4
Xanthone
Xanthone
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4 Cited Publications
Cat. No.: HY-N0126
CAS No.: 90-47-1
Category:  

Infection Xanthones Guttiferae Extract Garcinia mangostana Linn. Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Environmental Pollutants Calcium Channel Monoamine Oxidase

Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K +-induced vasoconstriction with IC50 values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca 2+ channels. Xanthone is the scaffold of several pharmacologically active compounds .
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12
alpha-Mangostin
alpha-Mangostin
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12 Publications Verification
Cat. No.: HY-N0328
CAS No.: 6147-11-1
Synonyms: α-Mangostin
Category:  

Xanthones Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer

Target:  

Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal Virus Protease

alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
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5
beta-Mangostin
beta-Mangostin
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5 Cited Publications
Cat. No.: HY-N0941
CAS No.: 20931-37-7
Synonyms: β-Mangostin
Category:  

Infection Xanthones Guttiferae Extract Garcinia mangostana Linn. Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

Bacterial Parasite Apoptosis

beta-Mangostin (β-Mangostin) is a xanthone compound present in Cratoxylum arborescens, with antibacterial and antimalarial activities. beta-Mangostin exhibits antimycobacterial activity against Mycobacterium tuberculosis with an MIC of 6.25 μg/mL. beta-Mangostin possesses in vitro antimalarial activity against Plasmodium falciparum, with an IC50 of 3.00 μg/mL. beta-Mangostin has potent anticancer activity against various cancers (such as hepatocellular carcinoma, leukaemic) .
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4
Isomangiferin
Isomangiferin
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4 Cited Publications
Cat. No.: HY-N0772
CAS No.: 24699-16-9
Category:  

Infection Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Liliaceae Extract Disease Research Fields

Target:  

VEGFR NOD-like Receptor (NLR) NF-κB Bacterial AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative

Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing .
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3
Garcinone C
Garcinone C
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3 Cited Publications
Cat. No.: HY-N6954
CAS No.: 76996-27-5
Category:  

Xanthones Garcinia oblongifolia Champ. ex Benth. Guttiferae Extract Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer

Target:  

ATM/ATR STAT CDK Hedgehog

Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .
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1
Gartanin
Gartanin
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1 Cited Publications
Cat. No.: HY-N6038
CAS No.: 33390-42-0
Category:  

Xanthones Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer

Target:  

Autophagy Fungal

Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells .
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1,3,5,8-Tetrahydroxyxanthone
1,3,5,8-Tetrahydroxyxanthone
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1 Cited Publications
Cat. No.: HY-N2050
CAS No.: 2980-32-7
Synonyms: Desmethylbellidifolin
Category:  

Neurological Disease Xanthones Gentianaceae Extract Plants Other Families Extract Phenols Polyphenols Swertia chirata Disease Research Fields Inflammation/Immunology

Target:  

Others

1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Swertia chirata. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity .
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1
3,6-Dihydroxyxanthone
3,6-Dihydroxyxanthone
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1 Cited Publications
Cat. No.: HY-W031510
CAS No.: 1214-24-0
Target:  

Drug Derivative

Research Areas:  

Cancer

3,6-Dihydroxyxanthone (compound 3) is a xanthone derivatives. 3,6-Dihydroxyxanthone (compound 3) has anticancer activity. 3,6-Dihydroxyxanthone (compound 3) can be used for cancer research .
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8-Deoxygartanin
8-Deoxygartanin
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1 Cited Publications
Cat. No.: HY-N6009
CAS No.: 33390-41-9
Category:  

Infection Xanthones Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:  

Parasite NF-κB

8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE) . 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum . 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM .
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1
Swertianolin
Swertianolin
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1 Cited Publications
Cat. No.: HY-N2192
CAS No.: 23445-00-3
Category:  

Xanthones Swertia bimaculata (Sieb. et Zucc.) Hook. f. et Thoms. ex C. B. Clark Gentianaceae Extract Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Bacterial p38 MAPK NF-κB NO Synthase Reactive Oxygen Species (ROS)

Swertianolin is a xanthone glycoside. Swertianolin can be isolated from plants of the Gentianaceae family (e.g., Gentiana campestris and Swertia punicea). Swertianolin inhibits p38 phosphorylation and NF-κB activation, and reduces NO and ROS production. Swertianolin exhibits anti-Helicobacter pylori activity with an IC50 of 6.1 μM and a minimum bactericidal concentration of 91.7 μM. Swertianolin modulates immune function in sepsis. Swertianolin is useful in the research of diseases such as Alzheimer's disease, hepatitis B, Helicobacter pylori infection, and sepsis .
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3-Isomangostin
3-Isomangostin
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1 Cited Publications
Cat. No.: HY-N6845
CAS No.: 19275-46-8
Category:  

Xanthones Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer

Target:  

DNA/RNA Synthesis Cholinesterase (ChE) CDK Aldose Reductase Bacterial

3-Isomangostin is a flavonoid compound that acts as an inhibitor of MTH1 and acetylcholinesterase, with an IC50 of 52 nM against MTH1 and IC50 values of 5.75 μM and 12.96 μM against AChE and BChE, respectively. 3-Isomangostin also inhibits human aldose reductase and CDK4/Cyclin D1 with IC50 values of 3.48 μM and 15.6 μM, respectively. 3-Isomangostin inhibits polyol pathway flux, competes with 8-oxo-dGTP for binding to the MTH1 active site through hydrogen bonding and hydrophobic xanthone interactions, blocks cell cycle progression, reduces cancer cell viability, and exhibits growth inhibitory effects against both normal and penicillin-resistant Staphylococcus aureus. 3-Isomangostin is used in research on Alzheimer's disease, diabetic complications, Staphylococcus aureus infections, and colon cancer .
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Macurin
Macurin
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Cat. No.: HY-N3347
CAS No.: 519-34-6
Synonyms: Maclurin
Category:  

Garcinia lancilimba C. Y. Wu ex Y. H. Li Guttiferae Extract Phenols Polyphenols Plants

Target:  

Others

Macurin is a xanthone that can be isolated from Garcinia lancilimba .
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9-Hydroxycalabaxanthone
9-Hydroxycalabaxanthone
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Cat. No.: HY-N2795
CAS No.: 35349-68-9
Synonyms: Xanthone I
Target:  

Parasite Bacterial

Research Areas:  

Infection

9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 μM) .
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Euxanthone
Euxanthone
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Cat. No.: HY-N3883
CAS No.: 529-61-3
Category:  

Flavonoids Garcinia oblongifolia Champ. ex Benth. Guttiferae Extract Plants Other Flavonoids

Target:  

Autophagy

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities .
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Cowaxanthone B
Cowaxanthone B
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Cat. No.: HY-N6248
CAS No.: 212842-64-3
Category:  

Infection Xanthones Phenols Polyphenols Plants Other Families Extract Disease Research Fields

Target:  

Bacterial

Cowaxanthone B is a xanthone isolated from the fruits of Garcinia cowa. Cowaxanthone B has weak antibacterial activity .
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Xanthone V1a
Xanthone V1a
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Cat. No.: HY-N10985
CAS No.: 103450-96-0
Category:  

Flavonoids Maclura fruticosa (Roxburgh) Corner Moraceae Extract Plants Other Flavonoids

Target:  

Free Radical Scavengers Drug Derivative

Xanthone V1a, a derivative of Xanthone (HY-N0126), is an antioxidant that can be found in the roots of Cudrania tricuspidata and twig extracts of Maclura fruticosa. Xanthone V1a exerts cytotoxic effects against colon, hepatocellular, and gastric carcinoma cells. Xanthone V1a exhibits scavenging activitys against DPPH and ABTS. Xanthone V1a can be used for the research of colon carcinoma, hepatocellular carcinoma, and gastric carcinoma .
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Isomorellic acid
Isomorellic acid
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Cat. No.: HY-N8727
CAS No.: 5262-69-1
Category:  

Ketones, Aldehydes, Acids Guttiferae Extract Plants Garcinia hanburyi Hook. f.

Target:  

Others

Isomorellic acid is a cytotoxic caged xanthone and can be used for cancer research .
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Cudraxanthone D
Cudraxanthone D
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Cat. No.: HY-N3647
CAS No.: 96552-41-9
Category:  

Xanthones Moraceae Extract Maclura tricuspidata Carriere Phenols Plants

Target:  

Others

Cudraxanthone D is a Xanthones product that can be isolated from the roots of Cudrania tricuspidata .
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Polygalaxanthone XI
Polygalaxanthone XI
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Cat. No.: HY-N6803
CAS No.: 857859-82-6
Category:  

Xanthones Polygalaceae Extract Phenols Polyphenols Plants Polygala tenuifolia Willd.

Target:  

Others

Polygalaxanthone XI, a xanthone glycoside isolated from the cortexes of Polygala tenuifolia, can be used in the study of expectorant, and tranquilizing agent .
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Garcinone B
Garcinone B
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Cat. No.: HY-149373
CAS No.: 76996-28-6
Category:  

Guttiferae Extract Garcinia mangostana Linn. Phenols Polyphenols Plants

Target:  

Angiotensin-converting Enzyme (ACE) SARS-CoV

Garcinone B, a xanthone derivative, is a nature product that could be isolated from the pericarp of Mangosteen. Garcinone B is a potent ACE2 and Mpro inhibitor. Garcinone B can be used in research of COVID-19 .
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