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Results for "

acetyl-CoA synthetase

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

5

Recombinant Proteins

2

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-104032
    Ac-CoA Synthase-IN-1
    5+ Cited Publications

    		 RSV Infection Metabolic Disease
    Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 μM . Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV) .
    Ac-CoA Synthase-IN-1
  • HY-P2827
    Acetyl-CoA synthetase

    ACS

    		 Acetyl-CoA synthetase Cancer
    Acetyl-CoA synthetase (ACS) is a key enzyme that catalyzes the conversion of acetate to acetyl-CoA (Ac-CoA). Acetyl-CoA synthetase catalyzes the formation of thioester bonds between coenzyme A and carboxylic acids, while simultaneously hydrolyzing ATP into AMP and pyrophosphate .
    Acetyl-CoA synthetase
  • HY-P2891
    Pyruvate Oxidase, Microorganisms

    PoxB

    		 Biochemical Assay Reagents Others
    Pyruvate Oxidase, Microorganisms (PoxB) is a peripheral membrane enzyme, isolated from microorganisms. Pyruvate oxidase catalyzes the oxidative decarboxylation of pyruvate to acetyl phosphate, carbon dioxide and water. Pyruvate oxidase is an important enzyme in bacterial metabolism and is often used in biochemical research .
    Pyruvate Oxidase, Microorganisms
  • HY-181784
    Ac-CoA-IN-1

    		Fungal Infection
    Ac-CoA-IN-1 is an acyl-AMP phosphate analog and weak inhibitor of Candida albicans acetyl-CoA synthetase 2, with no activity against Cryptococcus neoformans acetyl-CoA synthetase 1. Ac-CoA-IN-1 crystallizes with Cryptococcus neoformans ACS1 enzyme to yield structural insight for inhibitor design. Ac-CoA-IN-1 can be used for the research of fungal infections .
    Ac-CoA-IN-1
  • HY-182685
    MMV693183

    		Acetyl-CoA synthetase Parasite Infection
    MMV693183 is an orally active inhibitor of Plasmodium falciparum acetyl-CoA synthetase (AcAS), with an IC50 of 300 nM against Plasmodium falciparum. MMV693183 exhibits potent inhibitory activity against clinical isolates of malaria parasites, including Artemisinin (HY-B0094)-resistant strains. MMV693183 is metabolized in vivo into the active antimetabolite CoA-MMV693183, which exerts effects of killing asexual blood-stage parasites and blocking transmission to Anopheles mosquitoes by binding to and inhibiting the function of acetyl-CoA synthetase, thereby reducing the levels of acetyl-CoA and 4'-phosphopantetheine. In humanized mouse models, MMV693183 shows favorable in vivo efficacy, drug-like properties, and no significant cytotoxicity or off-target activity against human cells. MMV693183 is widely used in malaria-related research as a parasiticide and metabolic disruptor .
    MMV693183
  • HY-104032R
    Ac-CoA Synthase-IN-1 (Standard)

    		Reference Standards RSV Infection Metabolic Disease
    Ac-CoA Synthase-IN-1 (Standard) is the analytical standard of Ac-CoA Synthase-IN-1 (HY-104032). This product is intended for research and analytical applications. Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 μM . Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV) .
    Ac-CoA Synthase-IN-1 (Standard)
  • HY-E71018
    S-Acetyl-coenzyme A synthetase, Baker's yeast (S. cerevisiae)

    		Biochemical Assay Reagents Metabolic Disease
    S-Acetyl-coenzyme A synthetase, Baker's yeast (S. cerevisiae) (EC 6.2.1.1), catalyzes the production of acetyl-CoA and participates in the acetylation of histones in the cell nucleus.
    S-Acetyl-coenzyme A synthetase, Baker's yeast (S. cerevisiae)
  • HY-183249
    Ac-CoA Synthase-IN-2

    		Acetyl-CoA synthetase Fungal Infection
    Ac-CoA Synthase-IN-2 is an Ac-CoA Synthase (ACS) inhibitor and antifungal agent. Ac-CoA Synthase-IN-2 binds in the ATP/acetyl-AMP pocket of fungal and human ACS enzymes to exert competitive inhibition with ATP, and inhibits Cryptococcus neoformans CnKbc1-mediated acetoacetate-to-aceto-acetyl CoA conversion. Ac-CoA Synthase-IN-2 can be used for the research of fungal infections .
    Ac-CoA Synthase-IN-2

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