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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
111 Results for "
antitubercular
" in MedChemExpress (MCE) Product Catalog:
Products (111)
111 Results for "antitubercular" in MCE Product Catalog:
7
7 Publications Verification
Cat. No.: HY-N0804
CAS No.: 14259-46-2
Category:
Flavonoids Flavonones Rutaceae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Citrus
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5
5 Cited Publications
Synonyms: GSK656; GSK3036656; GSK070
Ganfeborole hydrochloride (GSK656) is a potent antitubercular agent, acting as an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC50 of 0.2 μM.
4
4 Cited Publications
Synonyms: Pyrazinecarboxamide; Pyrazinoic acid amide
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4
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SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC50 for cell killing of 50±8 nM. SQ109, targets MmpL3, is an antitubercular agent.
1
1 Cited Publications
Cat. No.: HY-19750
CAS No.: 1494675-86-3
TBA-7371 is an orally active and non-covalent inhibitor of Decaprenylphosphoryl-β-D-ribose oxidase (DprE1) of Mycobacterium tuberculosis (MIC=0.64 μg/mL). TBA-7371 can block the synthesis of arabinose in the bacterial cell wall, resulting in cell wall structural defects, thereby exerting an anti-tuberculosis effect. TBA-7371 can be used in the research of anti-tuberculosis drugs and has a synergistic bactericidal effect with Bedaquiline (HY-14881) and other drugs .
1
1 Cited Publications
Cat. No.: HY-N0804R
CAS No.: 14259-46-2
Category:
Flavonoids Flavonones Rutaceae Phenols Polyphenols Plants Citrus
Target:
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Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL .
Synonyms: GSK286
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GSK2556286 (GSK286) is an orally active and cholesterol-dependent Mycobacterium tuberculosis inhibitor. GSK2556286 inhibits Mycobacterium tuberculosis inside infected macrophages (IC50 = 0.07 μM in THP-1 cells), in the presence of cholesterol. GSK2556286 acts via Rv1625c, a membrane-bound adenylyl cyclase in Mycobacterium tuberculosis. GSK2556286 is an Rv1625 agonist leading to increased cAMP and reduced cholesterol metabolism. GSK2556286 can be studied in research for antitubercular purposes .
Cat. No.: HY-N9596
CAS No.: 20817-72-5
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Synonyms: Pyrazinecarboxamide (Standard); Pyrazinoic acid amide (Standard)
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Cat. No.: HY-B0271S
CAS No.: 1432059-16-9
Synonyms: Pyrazinecarboxamide-d3; Pyrazinoic acid amide-d3
Cat. No.: HY-132910
CAS No.: 2722634-44-6
Antitubercular agent-9 shows effective antitubercular activity with a MIC value of 1.03-2.32 μM.
Cat. No.: HY-146120
CAS No.: 1845719-91-6
Antitubercular agent-25 (Compound 28) is an anti-tubercular agent with an extracellular IC50 of 0.42 μM and an intracellular IC50 of 0.20 μM against M. tuberculosis H37Rv. Antitubercular agent-25 exhibits good metabolic stability .
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ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis .
Cat. No.: HY-W716669
CAS No.: 952-54-5
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Morinamide is an antibacterial agent, antitubercular agent and Pyrazine (HY-W013040) derivative. Morinamide can be used in the research of tuberculosis .
Cat. No.: HY-B0271S1
Synonyms: Pyrazinecarboxamide-13C,15N; Pyrazinoic acid amide-13C,15N
Cat. No.: HY-151960
CAS No.: 2883173-82-6
Antitubercular agent-36 (compound 53) is an antitubercular agent. Antitubercular agent-36 inhibits the growth of MtbH37Rv with a MIC90 value of 1.25 μg/mL. Antitubercular agent-36 can be used for the research of tuberculosis .
Cat. No.: HY-163437
CAS No.: 3037164-59-0
Antitubercular agent-45 (Compound 5g) is an antifungal and antitubercular agent. Antitubercular agent-45 inhibits S. aureus, MRSA, B. subtilis, E. coli, C. albicans with MIC values of 6.4, 10.8, 6.1, 8.4 , 8.1 μM respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
