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Results for "

autoimmune encephalomyelitis (EAE)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldehyde Dehydrogenase (ALDH) (1) Apoptosis (2) Aquaporin (2) Arginase (1) Atg8/LC3 (1) Beclin1 (1) Biochemical Assay Reagents (2) Caspase (1) CCR (1) CD28 (1) CRAC Channel (1) Endogenous Metabolite (11) FAAH (1) Histamine Receptor (5) IFNAR (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (5) Integrin (1) Interleukin Related (11) IRAK (1) Isotope-Labeled Compounds (1) JAK (6) LPL Receptor (6) Melatonin Receptor (2) MHC (2) Molecular Glues (1) Na+/K+ ATPase (1) NF-κB (1) NO Synthase (1) NOD-like Receptor (NLR) (1) Notch (1) Nuclear Factor of activated T Cells (NFAT) (1) Parasite (1) Phosphatase (1) PI3K (1) PKC (2) Potassium Channel (2) Reference Standards (6) REV-ERB (1) ROR (1) SARS-CoV (5) Smo (1) STAT (5) Thyroid Hormone Receptor (1) Tim3 (1) Transmembrane Glycoprotein (2) Trk Receptor (1) Tyrosinase (1) Wnt (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (3) Endocrinology (6) Infection (10) Inflammation/Immunology (61) Metabolic Disease (5) Neurological Disease (15)

By Targets:

Aldehyde Dehydrogenase (ALDH) (1)

Apoptosis (2)

Aquaporin (2)

Arginase (1)

Atg8/LC3 (1)

Beclin1 (1)

Biochemical Assay Reagents (2)

Caspase (1)

CCR (1)

CD28 (1)

CRAC Channel (1)

Endogenous Metabolite (11)

FAAH (1)

Histamine Receptor (5)

IFNAR (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Influenza Virus (5)

Integrin (1)

Interleukin Related (11)

IRAK (1)

Isotope-Labeled Compounds (1)

JAK (6)

LPL Receptor (6)

Melatonin Receptor (2)

MHC (2)

Molecular Glues (1)

Na+/K+ ATPase (1)

NF-κB (1)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

Notch (1)

Nuclear Factor of activated T Cells (NFAT) (1)

Parasite (1)

Phosphatase (1)

PI3K (1)

PKC (2)

Potassium Channel (2)

Reference Standards (6)

REV-ERB (1)

ROR (1)

SARS-CoV (5)

Smo (1)

STAT (5)

Thyroid Hormone Receptor (1)

Tim3 (1)

Transmembrane Glycoprotein (2)

Trk Receptor (1)

Tyrosinase (1)

Wnt (1)

By Research Areas:

Cancer (12)

Cardiovascular Disease (3)

Endocrinology (6)

Infection (10)

Inflammation/Immunology (61)

Metabolic Disease (5)

Neurological Disease (15)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1240

MOG (35-55) mouse, rat Maximum Cited Publications 9 Publications Verification Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
MOG (35-55) mouse, rat (Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat) is a minor component of CNS myelin. MOG (35-55) mouse, rat has encephalitogenic activity and induces T cell proliferative. MOG (35-55) mouse, rat induces Th1 cytokine response as well as relatively high levels of IgG antibodies. MOG (35-55) mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. MOG (35-55) mouse, rat (MOG (35-55)) can be used for experimental autoimmune encephalomyelitis (EAE) modeling .

HY-100754

Ritlecitinib 5+ Cited Publications PF-06651600	JAK Interleukin Related STAT	Inflammation/Immunology
Ritlecitinib (PF-06651600) is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC₅₀=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC₅₀ >10 μ M). Ritlecitinib rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .

HY-A0124A

Sapropterin dihydrochloride 2 Publications Verification (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride	Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-P3719

MOG(35-55) amide, mouse, rat 1 Publications Verification	CCR	Inflammation/Immunology
MOG (35-55) amide, mouse, rat the terminal amidation form of the 35-55 fragment of the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide (MOG (35-55) (HY-P1240)). MOG(35-55) amide, mouse, rat can be used for experimental autoimmune encephalomyelitis (EAE) modeling .

HY-168625

VAV1 degrader-3	Molecular Glues	Inflammation/Immunology
VAV1 degrader-3 (Example 185) is an orally active VAV1 molecular glue degrader (DC₅₀: 7 nM). VAV1 degrader-3 reduces immune cell activation, immune cell proliferation and the production of various cytokines. VAV1 degrader-3 can be used for research of inflammatory or autoimmune disorder. VAV1 degrader-3 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc. .

HY-101254

Luzindole Maximum Cited Publications 18 Publications Verification N-0774	Melatonin Receptor	Neurological Disease
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole preferentially targets MT2 (Mel_1b) over MT1 (Mel_1a) with K_i values of 10.2 and 158 nM for human MT2 and MT1, respectively. Luzindole suppresses experimental autoimmune encephalomyelitis (EAE), and exerts antidepressant-like activity .

HY-B0157

Ketotifen 3 Publications Verification HC 20-511	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus	Infection Inflammation/Immunology Endocrinology Cancer
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-B0157A

Ketotifen fumarate 3 Publications Verification HC 20511 fumarate	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus	Inflammation/Immunology Endocrinology Cancer
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N1363

Royal Jelly acid Maximum Cited Publications 6 Publications Verification (E)-Queen Bee Acid; (E)-10-Hydroxy-2-decenoic acid	Endogenous Metabolite NO Synthase NF-κB Parasite IFNAR	Infection Neurological Disease Inflammation/Immunology Cancer
Royal Jelly Acid ((E)-Queen Bee Acid) is a major fatty acid found in royal jelly with oral bioavailability, exhibiting anti-inflammatory, anticancer, antimalarial, antiprotozoal, and neuroregulatory activities. Royal Jelly Acid can be used for research in various fields, including cancer, infections, immune inflammation, and neurological diseases .

HY-P1240A

MOG (35-55) TFA Maximum Cited Publications 9 Publications Verification Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
MOG (35-55) (MOG (35-55)) TFA is a minor component of CNS myelin. MOG (35-55) (TFA) has encephalitogenic activity and induces T cell proliferative. MOG (35-55) (TFA) induces Th1 cytokine response as well as relatively high levels of IgG antibodies. MOG (35-55) (TFA) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. MOG (35-55) (MOG (35-55)) TFA can be used for experimental autoimmune encephalomyelitis (EAE) modeling .

HY-17606

Cenerimod ACT-334441	LPL Receptor	Inflammation/Immunology
Cenerimod (ACT-334441) is a potent, selective and orally active S1P1 receptor modulator, with an EC₅₀ of 1 nM. Cenerimod shows more than 36 fold selctivity for hS1P1 over hS1P2, hS1P3, hS1P4, and hS1P5 receptor subtypes (EC₅₀s=>10000, 228, 2134, and 36 nM, respectively). Cenerimod can attenuate murine experimental autoimmune encephalomyelitis (EAE) and murine sclerodermatous .

HY-N8441

Neriifolin 17β-Neriifolin	Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1	Cardiovascular Disease Inflammation/Immunology Cancer
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na ⁺, K ⁺-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells ^[2.

HY-P10936A

AQP4 (201-220) TFA	Aquaporin	Neurological Disease Inflammation/Immunology
AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. AQP4 (201-220) TFA can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica .

HY-109520

Glatiramer acetate 2 Publications Verification	MHC	Inflammation/Immunology Cancer
Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, inhibits Experimental autoimmune encephalomyelitis (EAE), and can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression .

HY-100754C

Ritlecitinib tosylate 5+ Cited Publications PF-06651600 tosylate	JAK Interleukin Related STAT	Inflammation/Immunology
Ritlecitinib (PF-06651600) tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC₅₀=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC₅₀ >10 μ M). Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .

HY-126328

PKC-theta inhibitor 1	PKC Interleukin Related	Inflammation/Immunology
PKC-theta inhibitor 1 is an orally active and selective ATP-competitive inhibitor of Protein Kinase Cθ (PKCθ), with a K_i value of 6 nM. PKC-theta inhibitor 1 inhibits T-cell-mediated inflammatory responses by suppressing the release of proinflammatory cytokines (IL-2 IC₅₀ = 0.21 μM in anti-CD3/CD28-stimulated PBMCs; IL-17 IC₅₀ = 1 μM in CD3/CD28-stimulated Th17 cells) PKC-theta inhibitor 1 significantly reduces symptoms in mice with ongoing experimental autoimmune encephalomyelitis (EAE). PKC-theta inhibitor 1 can be used for the study of T-cell-mediated inflammatory diseases such as multiple sclerosis .

HY-148103

SR12418	REV-ERB	Inflammation/Immunology
SR12418 is a REV-ERB-specific synthetic ligand with IC₅₀s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research .

HY-149004

SLF1081851 4 Publications Verification	LPL Receptor	Inflammation/Immunology
SLF1081851 is a Spns2 inhibitor, inhibits S1P release (IC₅₀=1.93 μM). SLF1081851 plays a key role in development and immune system .

HY-A0124

Sapropterin (6R)-BH4; (6R)-Tetrahydro-L-biopterin	Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-P10936

AQP4 (201-220)	Aquaporin	Neurological Disease Inflammation/Immunology
AQP4 (201-220) is an encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica .

HY-125726

Sulfo galactosylceramide (3'-sulfo)Galβ-Cer(d18:1/24:1); N-Nervonoyl Sulfatide; C24:1 Sulfatide	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Sulfo galactosylceramide (N-Nervonoyl Sulfatide; C24:1 Sulfatide) is a glycolipid and the major sulfolipid species in mature myelin. Sulfo galactosylceramide interacts with C-type lectins and immunoglobulin-like receptors, with the highest affinity for LMIR5. Sulfo galactosylceramide induces MCP-1 production by basophils but not mast cells, and increases NFAT activation via LMIR5. Sulfo galactosylceramide alleviates symptoms and improves survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE), and reduces inflammatory lesions and the number of infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.

HY-A0124AR

Sapropterin dihydrochloride (Standard) (6R)-BH4 dihydrochloride (Standard); (6R)-Tetrahydro-L-biopterin dihydrochloride (Standard)	Endogenous Metabolite Reference Standards	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride (Standard) is the analytical standard of Sapropterin dihydrochloride (HY-A0124A) . This product is intended for research and analytical applications. Sapropterin dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-P10532

Myelin basic protein, MBP (68-86)	PKC	Others Inflammation/Immunology
Myelin basic protein, MBP (68-86) is the portion of the 68th to 86th amino acid residues in the MBP protein sequence. Myelin basic protein, MBP (68-86) can act as an autoantigen, triggering the immune system to attack its own myelin. Myelin basic protein, MBP (68-86) is used as one of the immunogens in the experimental autoimmune encephalomyelitis (EAE) animal model to study immune responses associated with multiple sclerosis (MS) .

HY-164495

Sob-AM2	FAAH Thyroid Hormone Receptor	Inflammation/Immunology Endocrinology
Sob-AM2 is a potent substrate (K_m=1.3 μM) targeting fatty acid amide hydrolase (FAAH) expressed in the brain and has blood-brain barrier permeability. Sob-AM2 delivers high concentrations of Sobetirome (HY-14823) to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β (TRβ). In addition, Sob-AM2 can prevent myelin and axon degeneration in experimental autoimmune encephalomyelitis (EAE) mice .

HY-P990004

Anti-Mouse TIM-3 Antibody (B8.2C12)	Tim3	Inflammation/Immunology Cancer
Anti-Mouse TIM-3 Antibody (B8.2C12) is an anti-mouse TIM-3 IgG1 monoclonal antibody. Anti-Mouse TIM-3 Antibody (B8.2C12) can block the binding of Tim-3 with Phosphatidylserine (PtdSer) and CEACAM1 without interfering with the binding to Galectin-9. Anti-Mouse TIM-3 Antibody (B8.2C12) can inhibit tumor growth and activate tumor infiltrating CD8 ⁺ T cells. Anti-Mouse TIM-3 Antibody (B8.2C12) can be used for studying cancer such as breast cancer and colon cancer and constructing experimental autoimmune encephalomyelitis (EAE) models .

HY-P990144

Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2)	Integrin	Inflammation/Immunology Cancer
Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) is an anti-mouse/human VLA-4/CD49d IgG2b monoclonal antibody. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can reduce VLA-4 positive cells. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can inhibit the migration of Tc1 cells to tumors. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) inhibits the retention of leukemia cells in the spleen and bone marrow by blocking VLA-4. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can be used for research on inflammation conditions and cancer such as experimental autoimmune encephalomyelitis (EAE), melanoma and leukemia .

HY-N11451

Lacto-N-fucopentaose III LNFP-III	Arginase Aldehyde Dehydrogenase (ALDH) Indoleamine 2,3-Dioxygenase (IDO)	Inflammation/Immunology
Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation .

HY-115566

S1PL-IN-1	LPL Receptor Smo	Inflammation/Immunology
S1PL-IN-31 (compound ) is an oral active sphingosine-1-phosphate (S1P) lyase inhibitor with the IC₅₀ of 210 nM. S1PL-IN-31 is Smoothened receptor antagonist with the IC₅₀ of 440 nM. S1PL-IN-31 can be used for study of experimental autoimmune encephalomyelitis .

HY-P990250

Anti-Mouse DKK3 Antibody (DKK3-4.22)	Wnt	Inflammation/Immunology
Anti-Mouse DKK3 Antibody (DKK3-4.22) is an anti-mouse DKK3 IgG1 monoclonal antibody. Anti-Mouse DKK3 Antibody (DKK3-4.22) can improve kidney function and increases T cell infiltration. Anti-Mouse DKK3 Antibody (DKK3-4.22) can reduce skin inflammation by blocking the immunosuppressive function of DKK3. Anti-Mouse DKK3 Antibody (DKK3-4.22) can be used for researches on inflammation conditions such as unilateral ureteral obstruction (UUO) and experimental autoimmune encephalomyelitis (EAE) .

HY-P990156

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12)	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) is an anti-mouse Thy1.1/CD90.1 IgG2a monoclonal antibody. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can deplete CD90.1 ⁺ cells. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can clear Tregs. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can be used for researches on inflammation conditions and immune response such as airway inflammation and experimental autoimmune encephalomyelitis (EAE) .

HY-P990808

Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1)	Interleukin Related	Infection Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) is a rat-derived IgG2b κ type antibody inhibito, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can block IL-2 and IL-15. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can deplete natural killer (NK) cells and NKT cells. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can be used for the researches of cancer, infection, inflammation, immunology and metabolic disease, such as melanoma, experimental autoimmune encephalomyelitis (EAE) and diabetes .

HY-P5966

Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse MOG (40-54)	MHC	Inflammation/Immunology
Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse (MOG (40-54)) is a CD8-related self-antigenic epitope of the myelin oligodendrocyte glycoprotein (MOG) protein and is presented in association with H-2Db .

HY-P1409A

ADWX 1 TFA 1 Publications Verification	Potassium Channel	Inflammation/Immunology
ADWX 1 TFA is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC₅₀ value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 TFA ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 TFA can be used to study T cell-mediated autoimmune diseases .

HY-170409

BNN27	Trk Receptor Apoptosis	Neurological Disease Inflammation/Immunology
BNN27 is the agonist for TrkA receptor and p75NTR receptor, that exhibits neurotrophic and anti-apoptotic effects. BNN27 increases the levels of glutamate, GABA, and glutamine in the rat hippocampus and prefrontal cortex, improves glutamate turnover. BNN27 exhibits neuroprotective efficacy in mouse amyotrophic lateral sclerosis (ALS) model, exhibits anti-inflammatory efficacy in experimental autoimmune encephalomyelitis (EAE) model, exhibits retinal protective efficacy in rat diabete models. BNN27 is blood-brain barrier penetrable .

HY-W795993

TJU103	Transmembrane Glycoprotein	Inflammation/Immunology
TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4 ⁺ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research .

HY-120615

BMS-520	LPL Receptor	Neurological Disease Inflammation/Immunology
BMS-520 is a potent, orally active and selective sphingosine-1-phosphate 1 (S1P₁) agonist with an EC₅₀ of 0.47nM. BMS-520 shows ~3400-fold selectivity over S1P₃. BMS-520 demonstrates impressive efficacy in a rat model of arthritis and in a mouse experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. BMS-520 can be used for arthritis and EAE research .

HY-P3248

J5 peptide Myelin basic protein (85-99) antagonist	Biochemical Assay Reagents	Inflammation/Immunology
J5 peptide is an MBP inhibitor that competitively inhibits the binding of MBP_85-99 to HLA-DR2. J5 peptide alleviates PLP_139-151/MBP_85-99-induced experimental autoimmune encephalomyelitis (EAE) in mice. J5 peptide can be used in research on inflammatory and immune diseases .

HY-158374

BIO-8169	IRAK	Inflammation/Immunology
BIO-8169 is a selective inhibitor for interleukin receptor-associated kinase 4 (IRAK 4), with an IC₅₀ of 0.23 nM. BIO-8169 exhibits good pharmacokinetic character, reduces the production of pro-inflammatory cytokines, and attenuates the autoimmune encephalomyelitis in EAE mice model. BIO-8169 exhibits good blood brain penetrant with a rat Kpu,u of 0.7 .

HY-B0157AR

Ketotifen fumarate (Standard) HC 20511 fumarate (Standard)	Reference Standards Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus	Inflammation/Immunology Endocrinology Cancer
Ketotifen (fumarate) (Standard) is the analytical standard of Ketotifen (fumarate). This product is intended for research and analytical applications. Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-174999

JAK3-IN-18	JAK Tyrosinase	Neurological Disease Inflammation/Immunology
JAK3-IN-18 is an orally active JAK3 and TEC inhibitor, with IC₅₀s of 0.5391 nM and 12.40 nM, respectively. JAK3-IN-18 demonstrates outstanding selectivity over AK1, AK2, and TYk2, with selectivity ratios exceeding 10,000-fold. JAK3-IN-18 demonstrates excellent therapeutic efficacy in the experimental autoimmune encephalomyelitis (EAE) mouse model. JAK3-IN-18 can be used for the study of multiple sclerosis .

HY-100754A

Ritlecitinib malonate PF-06651600 malonate	JAK Interleukin Related STAT	Inflammation/Immunology
Ritlecitinib (PF-06651600) malonate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC₅₀=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC₅₀ >10 μ M). Ritlecitinib malonate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib malonate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE) .

HY-14977

CS-0777-P	LPL Receptor	Inflammation/Immunology
CS-0777-P, the phosphorylated form of CS-0777, acts as a potent and selective modulator of the S1P receptor-1 (S1P1). It exhibits approximately 320-fold higher agonist activity for human S1P1 compared to S1P3, with an EC50 of 1.1 nM. In pharmacological studies, CS-0777-P demonstrated significant effects in vitro as an S1P1 and S1P3 agonist, leading to lowered peripheral blood lymphocyte counts and suppressive effects on experimental autoimmune encephalomyelitis (EAE) in rats. Pharmacokinetic studies in rats revealed rapid lymphocyte count reductions following oral administration, making CS-0777 a promising candidate currently undergoing clinical trials for the treatment of multiple sclerosis (MS) .

HY-175984

S1P1 agonist 7	LPL Receptor	Inflammation/Immunology
S1P1 agonist 7 is a potent, orally active, and β-arrestin-biased S1P1 agonist (EC₅₀_{(G‑protein)} = 12.7 nM and EC₅₀_{(β‑arrestin)} = 3.23 nM). S1P1 agonist 7 demonstrates potent immunomodulatory activity and a favorable safety profile. S1P1 agonist 7 exhibits excellent metabolic stability, minimal to moderate CYP inhibition, and S1P3-sparing selectivity. S1P1 agonist 7 shows pharmacokinetics, effectively reduces circulating lymphocytes, and significantly alleviates disease severity in experimental autoimmune encephalomyelitis (EAE) mouse models under both prophylactic and therapeutic regimens. S1P1 agonist 7 can be used for multiple sclerosis (MS) research .

HY-P10297

PLP (190-209)	Biochemical Assay Reagents	Inflammation/Immunology
PLP (190-209) is a myelin proteolipid protein (PLP) fragment. PLP (190-209) is used to induce experimental autoimmune encephalomyelitis (EAE) animal models for multiple sclerosis research .

HY-N12108

Forphenicine	Phosphatase	Infection Inflammation/Immunology Cancer
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) .

HY-110216

5J-4	CRAC Channel	Inflammation/Immunology
5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation .

HY-P1409

ADWX 1	Potassium Channel	Inflammation/Immunology
ADWX 1 is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC₅₀ value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 can be used to study T cell-mediated autoimmune diseases .

HY-112863

RORγt inhibitor 3	ROR	Inflammation/Immunology
RORγt inhibitor 3 is an orally active and potent retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor. RORγt inhibitor 3 shows high binding affinity and inhibitory activity of Th17 cell differentiation. RORγt inhibitor 3 also shows efficacy in both mouse experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis (CIA) models .

HY-101254R

Luzindole (Standard) N-0774 (Standard)	Reference Standards Melatonin Receptor	Neurological Disease
Luzindole (Standard) is the analytical standard of Luzindole. This product is intended for research and analytical applications. Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole preferentially targets MT2 (Mel1b) over MT1 (Mel1a) with Ki values of 10.2 and 158 nM for human MT2 and MT1, respectively. Luzindole suppresses experimental autoimmune encephalomyelitis (EAE), and exerts antidepressant-like activity .

HY-P990819

Anti-Rat CD28 Antibody (JJ316)	CD28	Neurological Disease Inflammation/Immunology
Anti-Rat CD28 Antibody (JJ316) is a mouse-derived agonistic IgG1 κ type antibody, targeting to rat CD28. Anti-Rat CD28 Antibody (JJ316) can induce T cell proliferation. Anti-Rat CD28 Antibody (JJ316) can be used for the researches of inflammation, immunology and neurological disease, such as experimental autoimmune encephalomyelitis (EAE) and graft-versus-host disease (GvHD) .

Cat. No.	Product Name	Target	Research Area

HY-P1240

MOG (35-55) mouse, rat Maximum Cited Publications 9 Publications Verification Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
MOG (35-55) mouse, rat (Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat) is a minor component of CNS myelin. MOG (35-55) mouse, rat has encephalitogenic activity and induces T cell proliferative. MOG (35-55) mouse, rat induces Th1 cytokine response as well as relatively high levels of IgG antibodies. MOG (35-55) mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. MOG (35-55) mouse, rat (MOG (35-55)) can be used for experimental autoimmune encephalomyelitis (EAE) modeling .

HY-P3719

MOG(35-55) amide, mouse, rat 1 Publications Verification	CCR	Inflammation/Immunology
MOG (35-55) amide, mouse, rat the terminal amidation form of the 35-55 fragment of the myelin oligodendrocyte glycoprotein (MOG) immunogenic peptide (MOG (35-55) (HY-P1240)). MOG(35-55) amide, mouse, rat can be used for experimental autoimmune encephalomyelitis (EAE) modeling .

HY-P1240A

MOG (35-55) TFA Maximum Cited Publications 9 Publications Verification Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
MOG (35-55) (MOG (35-55)) TFA is a minor component of CNS myelin. MOG (35-55) (TFA) has encephalitogenic activity and induces T cell proliferative. MOG (35-55) (TFA) induces Th1 cytokine response as well as relatively high levels of IgG antibodies. MOG (35-55) (TFA) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. MOG (35-55) (MOG (35-55)) TFA can be used for experimental autoimmune encephalomyelitis (EAE) modeling .

HY-P1240B

MOG (35-55) acetate Maximum Cited Publications 9 Publications Verification Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate	Peptides	Neurological Disease Inflammation/Immunology
MOG (35-55) (Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat) acetate is a minor component of CNS myelin. MOG (35-55) (acetate) has encephalitogenic activity and induces T cell proliferative. MOG (35-55) (acetate) induces Th1 cytokine response as well as relatively high levels of IgG antibodies. MOG (35-55) (acetate) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination. MOG (35-55) (Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat) acetate can be used for experimental autoimmune encephalomyelitis (EAE) modeling .

HY-P10936A

AQP4 (201-220) TFA	Aquaporin	Neurological Disease Inflammation/Immunology
AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. AQP4 (201-220) TFA can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica .

HY-P0129

PLP (139-151) 1 Publications Verification	Peptides	Inflammation/Immunology
PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE).

HY-P5462A

PLP (180-199) TFA	Peptides	Inflammation/Immunology
PLP (180-199) TFA is the TFA salt form of PLP (180-199) (HY-P5462). PLP (180-199) TFA induces the activation and differentiation of T cells, and induces the experimental autoimmune encephalomyelitis (EAE) in mouse model .

HY-P10936

AQP4 (201-220)	Aquaporin	Neurological Disease Inflammation/Immunology
AQP4 (201-220) is an encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE) (characterized by midline lesions in the brain, retinal pathology, and lesions at the grey matter/white matter border zone in the spinal cord). AQP-4 is a target antigen in neuromyelitis optica .

HY-P10532

Myelin basic protein, MBP (68-86)	PKC	Others Inflammation/Immunology
Myelin basic protein, MBP (68-86) is the portion of the 68th to 86th amino acid residues in the MBP protein sequence. Myelin basic protein, MBP (68-86) can act as an autoantigen, triggering the immune system to attack its own myelin. Myelin basic protein, MBP (68-86) is used as one of the immunogens in the experimental autoimmune encephalomyelitis (EAE) animal model to study immune responses associated with multiple sclerosis (MS) .

HY-P3073

Myelin Basic Protein (1-11)	Peptides	Inflammation/Immunology
Myelin Basic Protein (1-11) is an encephalitogenic epitope of myelin basic protein (MBP). Myelin Basic Protein (1-11) can be used for induction of experimental autoimmune encephalomyelitis (EAE) .

HY-P5121A

γ-Fibrinogen 377-395 TFA	Peptides	Cardiovascular Disease
γ-Fibrinogen377-395 TFA is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 TFA blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 TFA can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation .

HY-P5966

Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse MOG (40-54)	MHC	Inflammation/Immunology
Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse (MOG (40-54)) is a CD8-related self-antigenic epitope of the myelin oligodendrocyte glycoprotein (MOG) protein and is presented in association with H-2Db .

HY-P1409A

ADWX 1 TFA 1 Publications Verification	Potassium Channel	Inflammation/Immunology
ADWX 1 TFA is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC₅₀ value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 TFA ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 TFA can be used to study T cell-mediated autoimmune diseases .

HY-P3248

J5 peptide Myelin basic protein (85-99) antagonist	Biochemical Assay Reagents	Inflammation/Immunology
J5 peptide is an MBP inhibitor that competitively inhibits the binding of MBP_85-99 to HLA-DR2. J5 peptide alleviates PLP_139-151/MBP_85-99-induced experimental autoimmune encephalomyelitis (EAE) in mice. J5 peptide can be used in research on inflammatory and immune diseases .

HY-P10456

[Leu144,Arg147]-PLP (139-151)	Peptides	Inflammation/Immunology
[Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP), with the tryptophan and histidine at positions 144 and 147 respectively replaced by leucine and arginine. [Leu144,Arg147]-PLP (139-151) also serves as a T cell receptor (TCR) antagonist for encephalitogenic Th1 clones, blocking their activation in vitro. Furthermore, [Leu144,Arg147]-PLP (139-151) can inhibit the development of experimental autoimmune encephalomyelitis (EAE) .

HY-P10297

PLP (190-209)	Biochemical Assay Reagents	Inflammation/Immunology
PLP (190-209) is a myelin proteolipid protein (PLP) fragment. PLP (190-209) is used to induce experimental autoimmune encephalomyelitis (EAE) animal models for multiple sclerosis research .

HY-P10522

MBP Ac1-9	Peptides	Others
MBP Ac1-9 refers to a peptide fragment of myelin basic protein (MBP). MBP Ac1-9 is an immunodominant epitope in the experimental autoimmune encephalomyelitis (EAE) model, which can induce T cell immune response and lead to pathological changes similar to multiple sclerosis. MBP Ac1-9 can be used to study T cell activation and autoimmune response .

HY-P1409

ADWX 1	Potassium Channel	Inflammation/Immunology
ADWX 1 is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC₅₀ value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 can be used to study T cell-mediated autoimmune diseases .

HY-P3817

Des-[Gly77,His78] Myelin Basic Protein (68-84), bovine	Peptides	Neurological Disease
Des-[Gly77,His78] Myelin Basic Protein (68-84) is a 68-84 sequence fragment of guinea pig myelin basic protein (GPMBP). Des-[Gly77,His78] Myelin Basic Protein (68-84) regulates functionally diverse encephalitogenic and proliferative activities of experimental autoimmune encephalomyelitis (EAE)-associated T cells .

HY-P5121

γ-Fibrinogen 377-395	Peptides	Cardiovascular Disease
γ-Fibrinogen377-395 is a fibrinogen-derived inhibitory peptide, as well as fibrinogen epitope. γ-Fibrinogen377-395 blocks microglia activation and inhibits fibrin-Mac-1 interactions in vitro, and suppresses experimental autoimmune encephalomyelitis (EAE) in mice in vivo. γ-Fibrinogen377-395 can be used for research in multiple sclerosis (MS), and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation .

HY-P10525

MBP Ac1-9 (4Y)	Peptides	Neurological Disease
MBP Ac1-9 (4Y) is a synthetic peptide derived from a fragment of myelin basic protein (MBP) that has undergone specific chemical modifications. MBP Ac1-9 (4Y) is able to form a complex with the MHC class II molecule I-Au and activate specific T cell receptor (TCR), thus playing a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). MBP Ac1-9 (4Y) can be used to study autoimmune diseases, especially those involving the central nervous system, such as multiple sclerosis .

HY-P11046

IIIM1	Interleukin Related	Inflammation/Immunology
IIIM1 is an orally active anti-inflammatory peptide. IIIM1 ameliorates the symptoms of experimental autoimmune encephalomyelitis (EAE) by stimulating the proliferation of regulatory T cells and inducing them to produce RA1, and regulating the cytokine balance. IIIM1 can be used in the research of multiple sclerosis (MS) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990004

Anti-Mouse TIM-3 Antibody (B8.2C12)	Tim3	Inflammation/Immunology Cancer
Anti-Mouse TIM-3 Antibody (B8.2C12) is an anti-mouse TIM-3 IgG1 monoclonal antibody. Anti-Mouse TIM-3 Antibody (B8.2C12) can block the binding of Tim-3 with Phosphatidylserine (PtdSer) and CEACAM1 without interfering with the binding to Galectin-9. Anti-Mouse TIM-3 Antibody (B8.2C12) can inhibit tumor growth and activate tumor infiltrating CD8 ⁺ T cells. Anti-Mouse TIM-3 Antibody (B8.2C12) can be used for studying cancer such as breast cancer and colon cancer and constructing experimental autoimmune encephalomyelitis (EAE) models .

HY-P990144

Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2)	Integrin	Inflammation/Immunology Cancer
Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) is an anti-mouse/human VLA-4/CD49d IgG2b monoclonal antibody. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can reduce VLA-4 positive cells. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can inhibit the migration of Tc1 cells to tumors. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) inhibits the retention of leukemia cells in the spleen and bone marrow by blocking VLA-4. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can be used for research on inflammation conditions and cancer such as experimental autoimmune encephalomyelitis (EAE), melanoma and leukemia .

HY-P990250

Anti-Mouse DKK3 Antibody (DKK3-4.22)	Wnt	Inflammation/Immunology
Anti-Mouse DKK3 Antibody (DKK3-4.22) is an anti-mouse DKK3 IgG1 monoclonal antibody. Anti-Mouse DKK3 Antibody (DKK3-4.22) can improve kidney function and increases T cell infiltration. Anti-Mouse DKK3 Antibody (DKK3-4.22) can reduce skin inflammation by blocking the immunosuppressive function of DKK3. Anti-Mouse DKK3 Antibody (DKK3-4.22) can be used for researches on inflammation conditions such as unilateral ureteral obstruction (UUO) and experimental autoimmune encephalomyelitis (EAE) .

HY-P990156

Anti-Mouse Thy1.1/CD90.1 Antibody (19E12)	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) is an anti-mouse Thy1.1/CD90.1 IgG2a monoclonal antibody. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can deplete CD90.1 ⁺ cells. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can clear Tregs. Anti-Mouse Thy1.1/CD90.1 Antibody (19E12) can be used for researches on inflammation conditions and immune response such as airway inflammation and experimental autoimmune encephalomyelitis (EAE) .

HY-P990808

Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1)	Interleukin Related	Infection Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) is a rat-derived IgG2b κ type antibody inhibito, targeting to mouse CD122/IL-2Rβ. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can block IL-2 and IL-15. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can deplete natural killer (NK) cells and NKT cells. Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) can be used for the researches of cancer, infection, inflammation, immunology and metabolic disease, such as melanoma, experimental autoimmune encephalomyelitis (EAE) and diabetes .

HY-P990819

Anti-Rat CD28 Antibody (JJ316)	CD28	Neurological Disease Inflammation/Immunology
Anti-Rat CD28 Antibody (JJ316) is a mouse-derived agonistic IgG1 κ type antibody, targeting to rat CD28. Anti-Rat CD28 Antibody (JJ316) can induce T cell proliferation. Anti-Rat CD28 Antibody (JJ316) can be used for the researches of inflammation, immunology and neurological disease, such as experimental autoimmune encephalomyelitis (EAE) and graft-versus-host disease (GvHD) .

HY-P990206

Anti-Mouse Jagged 2 Antibody (HMJ2-1)	Notch Interleukin Related	Inflammation/Immunology
Anti-Mouse Jagged 2 Antibody (HMJ2-1) is an anti-mouse Jagged 2 IgG monoclonal antibody. Anti-Mouse Jagged 2 Antibody (HMJ2-1) regulates Treg/Th17 balance through IL-9. Anti-Mouse Jagged 2 Antibody (HMJ2-1) increases Jagged2-Notch signaling through activation of RBP-Jk. Anti-Mouse Jagged 2 Antibody (HMJ2-1) can be used for researches on inflammation conditions and xenotransplantation such as experimental autoimmune encephalomyelitis (EAE) .

HY-P992382

IC 100	Interleukin Related	Neurological Disease Inflammation/Immunology
IC 100 is a humanized IgG4κ monoclonal antibody targeting apoptosis-associated speck-like protein (ASC) with blood-brain barrier permeability. IC 100 specifically inhibits ASC after being endocytosed via its Fc segment, blocks ASC polymerization and inflammasome activation, suppresses IL-1β release, forms complexes with ASC and TRIM21, and evades TRIM21-mediated proteasomal degradation. IC 100 alleviates symptoms associated with autoimmune encephalomyelitis, reduces immune cell infiltration and microglial activation in the mouse EAE model. IC 100 is suitable for research on neuroinflammatory and inflammasome-related diseases such as multiple sclerosis. Isotype comparison: HY-P99003 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0124A

Sapropterin dihydrochloride 2 Publications Verification (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Endogenous Metabolite
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-B0157

Ketotifen 3 Publications Verification HC 20-511	Infection Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-B0157A

Ketotifen fumarate 3 Publications Verification HC 20511 fumarate	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N1363

Royal Jelly acid Maximum Cited Publications 6 Publications Verification (E)-Queen Bee Acid; (E)-10-Hydroxy-2-decenoic acid	Animals Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite NO Synthase NF-κB Parasite IFNAR
Royal Jelly Acid ((E)-Queen Bee Acid) is a major fatty acid found in royal jelly with oral bioavailability, exhibiting anti-inflammatory, anticancer, antimalarial, antiprotozoal, and neuroregulatory activities. Royal Jelly Acid can be used for research in various fields, including cancer, infections, immune inflammation, and neurological diseases .

HY-N8441

Neriifolin 17β-Neriifolin	Apocynaceae Classification of Application Fields Cardiacglycosides Cerbera manghas Linn. Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na ⁺, K ⁺-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells ^[2.

HY-N11451

Lacto-N-fucopentaose III LNFP-III	Polysaccharides Animals Saccharides Source Classification	Arginase Aldehyde Dehydrogenase (ALDH) Indoleamine 2,3-Dioxygenase (IDO)
Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation .

HY-B0157AR

Ketotifen fumarate (Standard) HC 20511 fumarate (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (fumarate) (Standard) is the analytical standard of Ketotifen (fumarate). This product is intended for research and analytical applications. Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N12108

Forphenicine	Microorganisms Ketones, Aldehydes, Acids Phenols Source Classification	Phosphatase
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) .

HY-B0157R

Ketotifen (Standard) HC 20-511 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus
Ketotifen (Standard) is the analytical standard of Ketotifen. This product is intended for research and analytical applications. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

Cat. No.	Product Name	Chemical Structure

HY-B0157S1

Ketotifen-d3

Ketotifen-d₃ (HC 20-511-d₃) is deuterium labeled Ketotifen. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

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