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Results for "

carbazole alkaloid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Autophagy (1) Bacterial (6) Caspase (1) CDK (1) Drug Derivative (4) Fungal (2) HIV (1) IKK (2) Interleukin Related (5) JNK (2) NF-κB (2) p38 MAPK (3) Parasite (2) Reference Standards (2) SARS-CoV (1) Topoisomerase (1) Virus Protease (1) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Infection (11) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121368

Mahanine	Parasite	Infection Inflammation/Immunology Cancer
Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research.

HY-W100287

Murrayafoline A	NF-κB p38 MAPK Interleukin Related IKK JNK β-catenin Wnt	Neurological Disease Inflammation/Immunology Cancer
Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056)-induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer .

HY-N9488

Girinimbine Girinimbin	Apoptosis Bacterial Parasite	Infection Inflammation/Immunology Cancer
Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities .

HY-W047478

3-Methylcarbazole NSC 10154	Fungal Interleukin Related	Infection Inflammation/Immunology Cancer
3-Methylcarbazole (NSC 10154) is a carbazole alkaloid with an IC₅₀ of 25 μg/mL against human fibrosarcoma cells. 3-Methylcarbazole inhibits mycelial growth and conidial germination of a variety of phytopathogenic fungi. 3-Methylcarbazole exhibits anti-inflammatory and antitumor activities. 3-Methylcarbazole can be used in studies related to fibrosarcoma, phytopathogenic fungal infections and inflammatory diseases .

HY-111523

Isomahanine	p38 MAPK Apoptosis Autophagy Caspase	Metabolic Disease
Isomahanine, carbazole alkaloid, is an antioxidative agent. Isomahanine has DPPH radical scavenging activity with an IC₅₀ value of 24 μM .

HY-117396

Isomahanimbine	Others	Others
Isomahanimbine is a natural carbazole alkaloid found in Murraya koenigii (L.) Spreng .

HY-116933

Murrayanol	Topoisomerase Bacterial	Infection Inflammation/Immunology
Murrayanol is a natural carbazole alkaloid with a variety of biological activities. Murrayanol shows anti-inflammatory, topoisomerase I and topoisomerase II (Topoisomerase) inhibition activities. Murrayanol also as a mosquitocidal and antimicrobial .

HY-N16649

Clausenalansine B	Others	Neurological Disease
Clausenalansine B (Compound 2) is a carbazole alkaloid found in the fruits of Clausena lansium. Clausenalansine B exhibits potent neuroprotective effects. Clausenalansine B prevents SH-SY5Y cells death from 6-OHDA (HY-B1081A) with an EC₅₀ of 5.82 μM. Clausenalansine B can be used for the research of neurological disease, such as Parkinson’s disease .

HY-N8361

Glycoborinine	HIV Apoptosis	Infection Cancer
Glycoborinine, a natural carbazole alkaloid, can be isolated from Glycosmis pentaphylla. Glycoborinine induces HepG2 cell apoptosis through mitochondrial pathway. Glycoborinine also inhibits HIV replication in cells .

HY-N3288

Methyl carbazole-3-carboxylate	Others	Others
Methylcarbazole-3-carboxylate is a carbazole alkaloid can be isolated from the peel of Clausena lansium (Lour.) Skeels .

HY-N15266

Mukonidine	Bacterial	Infection
Mukonidine is a carbazole alkaloid with antibacterial activity .

HY-W710314

3,4-Dimethoxy-1,2-dimethyl-9H-carbazole	Bacterial	Infection
3,4-Dimethoxy-1,2-dimethyl-9H-carbazole is a carbazole alkaloid that can be used in the synthesis of baccamycin.

HY-N3593

Clausine Z 1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde	CDK	Others
Clausine Z (1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde) is an alkaloid CDK5 inhibitor isolated from the plant from Momordica charantia .

HY-N15268

Koenine	SARS-CoV Virus Protease	Infection
Koenine is a carbazole alkaloid. It is predicted that Koenine has strong binding affinity and inhibitory ability to SARS-CoV-2 main protease (M ^pro), which can be used in the research of anti-novel coronavirus drugs .

HY-N13286

Glycozolidal	Bacterial	Infection
Glycozolidal (compound 12) is a carbazole alkaloid with antibacterial activity against P. gingivalis. Glycozolidal is cytotoxic against human gingival fibroblasts (HGFs) and monocytes (U937) in vitro with IC₅₀ values of 120.86 µg/mL and 97.74 µg/mL, respectively .

HY-N13828

1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole	Bacterial Interleukin Related	Infection Inflammation/Immunology
1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole (Compound 19) is a carbazole alkaloid that can be isolated from Murraya koenigii. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole exhibits anti-inflammatory and antimicrobial activities. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can inhibit the production of pro-inflammatory cytokines TNF-α and IL-6 . 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole has IC₅₀ values of 10.9 μM and 95 μM for Bacillus cereus and Staphylococcus aureus, respectively. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can be used in the research of inflammatory and infectious diseases .

HY-W647293

3-Methyl-9H-carbazol-2-ol	Drug Derivative	Others
3-Methyl-9H-carbazol-2-ol (compound 7) is a carbazole alkaloid that can be found in the twigs and leaves of Glycosmis montana Pierre (Rutaceae) .

HY-W1006753

2-Methoxy-3-methylcarbazole	Drug Derivative	Others
2-Methoxy-3-methylcarbazole is a natural carbazole alkaloid .

HY-N19719

Bispyrayafoline	Drug Derivative	Inflammation/Immunology
Bispyrayafoline is a pyrrolidone and antioxidant with an IC₅₀ value of 13.85 μM against DPPH. Bispyrayafoline can be found in the leaves of Murraya koenigii (Linn.) Spreng. Bispyrayafoline's antioxidant activity is concentration-dependent but time-independent. Bispyrayafoline can be utilized in studies concerning oxidative damage .

HY-N16748

Heptazoline	Others	Cardiovascular Disease
Heptazoline is a carbazole alkaloid that can be isolated from the stem bark of Clausena excavata. Heptazoline exhibits significant antiplatelet aggregation activity (inhibiting platelet aggregation induced by arachidonic acid, collagen, etc.) and certain vasodilatory activity (inhibiting norepinephrine-induced contraction of rat aorta). Heptazoline can be used in antithrombotic research in the cardiovascular field .

HY-N3993

Clausine I	Drug Derivative	Others
Clausine I is a natural alkaloid.

HY-N16714

Clausine K	Others	Cancer
Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC₅₀ = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC₅₀ 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods .

HY-W047478R

3-Methylcarbazole (Standard) NSC 10154 (Standard)	Reference Standards Interleukin Related Fungal	Infection Inflammation/Immunology Cancer
3-Methylcarbazole (NSC 10154) Standard is the analytical standard of 3-Methylcarbazole (HY-W047478). This product is intended for research and analytical applications. 3-Methylcarbazole (NSC 10154) is a carbazole alkaloid with an IC₅₀ of 25 μg/mL against human fibrosarcoma cells. 3-Methylcarbazole inhibits mycelial growth and conidial germination of a variety of phytopathogenic fungi. 3-Methylcarbazole exhibits anti-inflammatory and antitumor activities. 3-Methylcarbazole can be used in studies related to fibrosarcoma, phytopathogenic fungal infections and inflammatory diseases.

HY-W100287R

Murrayafoline A (Standard)	NF-κB Reference Standards p38 MAPK Interleukin Related IKK JNK β-catenin Wnt	Neurological Disease Inflammation/Immunology Cancer
Murrayafoline A (Standard) is the analytical standard of Murrayafoline A (HY-W100287). This product is intended for research and analytical applications. Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056)-induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer .

Mahanine	Infection Alkaloids Monophenols Classification of Application Fields Rutaceae Murraya koenigii (L.) Spreng Phenols Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Parasite
Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research.

Murrayafoline A	Alkaloids Murraya tetramera C. C. Huang Rutaceae Carbazole Alkaloids Plants Source Classification	NF-κB p38 MAPK Interleukin Related IKK JNK β-catenin Wnt
Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056)-induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer .

Girinimbine Girinimbin	Infection Alkaloids Classification of Application Fields Rutaceae Murraya koenigii (L.) Spreng Plants Disease Research Fields Inflammation/Immunology Indole Alkaloids Source Classification	Apoptosis Bacterial Parasite
Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities .

3-Methylcarbazole NSC 10154	Alkaloids Structural Classification other families Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification Cancer	Fungal Interleukin Related
3-Methylcarbazole (NSC 10154) is a carbazole alkaloid with an IC₅₀ of 25 μg/mL against human fibrosarcoma cells. 3-Methylcarbazole inhibits mycelial growth and conidial germination of a variety of phytopathogenic fungi. 3-Methylcarbazole exhibits anti-inflammatory and antitumor activities. 3-Methylcarbazole can be used in studies related to fibrosarcoma, phytopathogenic fungal infections and inflammatory diseases .

Isomahanine	Alkaloids Rutaceae Murraya koenigii (L.) Spreng Plants Indole Alkaloids	p38 MAPK Apoptosis Autophagy Caspase
Isomahanine, carbazole alkaloid, is an antioxidative agent. Isomahanine has DPPH radical scavenging activity with an IC₅₀ value of 24 μM .

Isomahanimbine	Alkaloids Rutaceae Murraya koenigii (L.) Spreng Plants Indole Alkaloids	Others
Isomahanimbine is a natural carbazole alkaloid found in Murraya koenigii (L.) Spreng .

Murrayanol	Alkaloids Rutaceae Murraya koenigii (L.) Spreng Plants Indole Alkaloids	Topoisomerase Bacterial
Murrayanol is a natural carbazole alkaloid with a variety of biological activities. Murrayanol shows anti-inflammatory, topoisomerase I and topoisomerase II (Topoisomerase) inhibition activities. Murrayanol also as a mosquitocidal and antimicrobial .

Clausenalansine B	Structural Classification Alkaloids Clausena lansium (Lour.) Skeels Rutaceae Carbazole Alkaloids Plants Source Classification	Others
Clausenalansine B (Compound 2) is a carbazole alkaloid found in the fruits of Clausena lansium. Clausenalansine B exhibits potent neuroprotective effects. Clausenalansine B prevents SH-SY5Y cells death from 6-OHDA (HY-B1081A) with an EC₅₀ of 5.82 μM. Clausenalansine B can be used for the research of neurological disease, such as Parkinson’s disease .

Glycoborinine	Alkaloids Glycosmis arborea (Retz.) Corrêa Rutaceae Plants Indole Alkaloids Source Classification	HIV Apoptosis
Glycoborinine, a natural carbazole alkaloid, can be isolated from Glycosmis pentaphylla. Glycoborinine induces HepG2 cell apoptosis through mitochondrial pathway. Glycoborinine also inhibits HIV replication in cells .

Methyl carbazole-3-carboxylate	Alkaloids Clausena lansium (Lour.) Skeels Rutaceae Plants Source Classification	Others
Methylcarbazole-3-carboxylate is a carbazole alkaloid can be isolated from the peel of Clausena lansium (Lour.) Skeels .

Mukonidine	Alkaloids Rutaceae Murraya koenigii (L.) Spreng Plants Indole Alkaloids Source Classification	Bacterial
Mukonidine is a carbazole alkaloid with antibacterial activity .

Clausine Z 1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde	Alkaloids Rutaceae Plants Clausena excavata N. L. Burman Indole Alkaloids Source Classification	CDK
Clausine Z (1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde) is an alkaloid CDK5 inhibitor isolated from the plant from Momordica charantia .

Koenine	Alkaloids Pyrrole Alkaloids Rutaceae Murraya koenigii (L.) Spreng Plants Source Classification	SARS-CoV Virus Protease
Koenine is a carbazole alkaloid. It is predicted that Koenine has strong binding affinity and inhibitory ability to SARS-CoV-2 main protease (M ^pro), which can be used in the research of anti-novel coronavirus drugs .

Glycozolidal	Alkaloids Glycosmis arborea (Retz.) Corrêa Rutaceae Carbazole Alkaloids Plants Source Classification	Bacterial
Glycozolidal (compound 12) is a carbazole alkaloid with antibacterial activity against P. gingivalis. Glycozolidal is cytotoxic against human gingival fibroblasts (HGFs) and monocytes (U937) in vitro with IC₅₀ values of 120.86 µg/mL and 97.74 µg/mL, respectively .

1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole	Alkaloids Rutaceae Murraya koenigii (L.) Spreng Carbazole Alkaloids Plants Indole Alkaloids Source Classification	Bacterial Interleukin Related
1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole (Compound 19) is a carbazole alkaloid that can be isolated from Murraya koenigii. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole exhibits anti-inflammatory and antimicrobial activities. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can inhibit the production of pro-inflammatory cytokines TNF-α and IL-6 . 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole has IC₅₀ values of 10.9 μM and 95 μM for Bacillus cereus and Staphylococcus aureus, respectively. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can be used in the research of inflammatory and infectious diseases .

3-Methyl-9H-carbazol-2-ol	Structural Classification Alkaloids Pyrrole Alkaloids Glycosmis montana Pierre Rutaceae Plants Source Classification	Drug Derivative
3-Methyl-9H-carbazol-2-ol (compound 7) is a carbazole alkaloid that can be found in the twigs and leaves of Glycosmis montana Pierre (Rutaceae) .

2-Methoxy-3-methylcarbazole	Structural Classification Alkaloids Rutaceae Murraya koenigii (L.) Spreng Plants Indole Alkaloids Source Classification	Drug Derivative
2-Methoxy-3-methylcarbazole is a natural carbazole alkaloid .

Bispyrayafoline	Structural Classification Alkaloids Rutaceae Murraya koenigii (L.) Spreng Carbazole Alkaloids Plants Source Classification	Drug Derivative
Bispyrayafoline is a pyrrolidone and antioxidant with an IC₅₀ value of 13.85 μM against DPPH. Bispyrayafoline can be found in the leaves of Murraya koenigii (Linn.) Spreng. Bispyrayafoline's antioxidant activity is concentration-dependent but time-independent. Bispyrayafoline can be utilized in studies concerning oxidative damage .

Heptazoline	Structural Classification Alkaloids Rutaceae Carbazole Alkaloids Plants Clausena excavata N. L. Burman Source Classification	Others
Heptazoline is a carbazole alkaloid that can be isolated from the stem bark of Clausena excavata. Heptazoline exhibits significant antiplatelet aggregation activity (inhibiting platelet aggregation induced by arachidonic acid, collagen, etc.) and certain vasodilatory activity (inhibiting norepinephrine-induced contraction of rat aorta). Heptazoline can be used in antithrombotic research in the cardiovascular field .

Clausine I	Structural Classification Alkaloids Rutaceae Carbazole Alkaloids Plants Clausena excavata N. L. Burman Source Classification	Drug Derivative
Clausine I is a natural alkaloid.

Clausine K	Structural Classification Alkaloids Pyrrole Alkaloids Rutaceae Plants Clausena excavata N. L. Burman Source Classification	Others
Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC₅₀ = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC₅₀ 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods .

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carbazole alkaloid

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