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Results for "

cold

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Autophagy (3) Bacterial (7) Biochemical Assay Reagents (2) C-type Lectin-like Receptors (CTLRs) (1) Calcium Channel (9) Carboxypeptidase (2) Complement System (1) COX (1) Drug Derivative (1) Drug Isomer (1) Drug Metabolite (1) Endogenous Metabolite (4) Environmental Pollutants (2) FGFR (1) GABA Receptor (2) Heme Oxygenase (HO) (1) Histamine Receptor (7) iGluR (4) Influenza Virus (1) Insecticide (2) Interleukin Related (3) Isotope-Labeled Compounds (3) JNK (1) Keap1-Nrf2 (1) mAChR (4) MicroRNA (3) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) MMP (1) MyD88 (1) NF-κB (2) Parasite (2) PD-1/PD-L1 (3) PERK (1) PGC-1α (1) Phosphodiesterase (PDE) (1) Potassium Channel (4) PPAR (1) Prostaglandin Receptor (1) Ras (3) Reactive Oxygen Species (ROS) (1) Reference Standards (12) Sex Pheromone (1) Sigma Receptor (1) Sodium Channel (4) STING (3) TNF Receptor (1) Toll-like Receptor (TLR) (2) TRP Channel (8) VEGFR (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (9) Endocrinology (5) Infection (12) Inflammation/Immunology (20) Metabolic Disease (7) Neurological Disease (23)

By Targets:

5-HT Receptor (2)

Autophagy (3)

Bacterial (7)

Biochemical Assay Reagents (2)

C-type Lectin-like Receptors (CTLRs) (1)

Calcium Channel (9)

Carboxypeptidase (2)

Complement System (1)

COX (1)

Drug Derivative (1)

Drug Isomer (1)

Drug Metabolite (1)

Endogenous Metabolite (4)

Environmental Pollutants (2)

FGFR (1)

GABA Receptor (2)

Heme Oxygenase (HO) (1)

Histamine Receptor (7)

iGluR (4)

Influenza Virus (1)

Insecticide (2)

Interleukin Related (3)

Isotope-Labeled Compounds (3)

JNK (1)

Keap1-Nrf2 (1)

mAChR (4)

MicroRNA (3)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (1)

MMP (1)

MyD88 (1)

NF-κB (2)

Parasite (2)

PD-1/PD-L1 (3)

PERK (1)

PGC-1α (1)

Phosphodiesterase (PDE) (1)

Potassium Channel (4)

PPAR (1)

Prostaglandin Receptor (1)

Ras (3)

Reactive Oxygen Species (ROS) (1)

Reference Standards (12)

Sex Pheromone (1)

Sigma Receptor (1)

Sodium Channel (4)

STING (3)

TNF Receptor (1)

Toll-like Receptor (TLR) (2)

TRP Channel (8)

VEGFR (1)

By Research Areas:

Cancer (23)

Cardiovascular Disease (9)

Endocrinology (5)

Infection (12)

Inflammation/Immunology (20)

Metabolic Disease (7)

Neurological Disease (23)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0303

Diphenhydramine 5+ Cited Publications	Histamine Receptor Bacterial Endogenous Metabolite iGluR	Neurological Disease Inflammation/Immunology Cancer
Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) .

HY-W145499

Zinc Gluconate 1 Publications Verification	PPAR NF-κB Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Zinc Gluconate is a zinc supplement in the form of a gluconate salt, which plays a role in various physiological processes such as immune function, wound healing, and olfaction. Zinc Gluconate has a LD₅₀ of 39.6 mg/kg in mice (Tail vein injection). Zinc Gluconate can be used in the research of inflammation, zinc deficiency, colds, cancer, and nutritional supplements .

HY-P991097

Pumitamig PM-8002; BNT-327	VEGFR PD-1/PD-L1	Cancer
Pumitamig (PM-8002, BNT-327) is a bispecific antibody targeting PD-L1 and VEGF-A, with immune activation and anti-angiogenic activities. By binding to PD-L1, Pumitamig restores the function of effector T cells, while neutralizing VEGF-A in the tumor microenvironment to reverse its inhibition on the infiltration and activation of immune cells and normalize tumor blood vessels. Pumitamig can also be combined with various ADCs targeting TROP2, B7H3, HER2, HER3 for the research of advanced/metastatic solid tumors, including non-small cell lung cancer, ovarian cancer, triple-negative breast cancer, cervical cancer, etc. Pumitamig also exhibits potential efficacy in "cold" tumors with low PD-L1 expression that are insensitive to immunotherapy .

HY-B0480

Brompheniramine maleate 2 Publications Verification (±)-Brompheniramine maleate	Histamine Receptor mAChR Potassium Channel Sodium Channel Calcium Channel	Neurological Disease Inflammation/Immunology Endocrinology
Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a K_d of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC₅₀s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research .

HY-115506

PF-05105679	TRP Channel	Neurological Disease
PF-05105679, a chemical probe, is an orally active and selective TRPM8 antagonist with an IC₅₀ of 103 nM. PF-05105679 has the potential for cold-related pain .

HY-P99050

Sutimlimab BIVV009; IPN-009; TNT009	Complement System	Cardiovascular Disease Inflammation/Immunology
Sutimlimab is a humanized monoclonal IgG4 antibody. Sutimlimab inhibits complement protein component 1, s subcomponent (C1s). Sutimlimab blocks C3 and C4 activation. Sutimlimab can be used for the research of cold agglutinin disease and complement-mediated hemolytic uremic syndrome .

HY-18099

S1RA 3 Publications Verification E-52862	Sigma Receptor 5-HT Receptor	Neurological Disease
S1RA (E-52862) is a highly selective σ1 receptor (σ1R) antagonist with K_is of 17 nM and 23.5 nM for human σ1R and guinea pig σ1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT_2B receptor (K_i= 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin (HY-17371)-treated mice .

HY-D0007

Blue Tetrazolium Tetrazolium blue	Biochemical Assay Reagents	Others
Blue Tetrazolium is a tetrazolium salt chromogenic dye that can be reduced to a dark blue formazan product. Blue Tetrazolium is applicable for assays such as succinate dehydrogenase activity detection and reducing sugar quantification. Blue Tetrazolium also serves as a novel corrosion inhibitor for cold-rolled steel in hydrochloric acid solutions. Blue Tetrazolium has a broad wavelength range (480-600 nm), with the maximum absorbance observed at 540 nm .

HY-116003

12,13-DiHOME	Endogenous Metabolite	Metabolic Disease
12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders .

HY-110181

M8-B 1 Publications Verification	TRP Channel	Metabolic Disease
M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb) .

HY-156649

Vorbipiprant CR6086	Prostaglandin Receptor Interleukin Related MMP PD-1/PD-L1	Cardiovascular Disease Inflammation/Immunology Cancer
Vorbipiprant (CR6086) is an orally active EP4 receptor antagonist with high selectivity for the human EP4 receptor (K_i: 16.6 nM). Vorbipiprant has immunomodulatory, anti-inflammatory, antitumor, and anti-angiogenic activities. Vorbipiprant can inhibit the expression of multiple pro-inflammatory cytokines and the activation of immune cells, and convert "cold" tumors unresponsive to immune checkpoint inhibitors into "hot" tumors. Vorbipiprant is used in the research of diseases such as rheumatoid arthritis and colon cancer .

HY-B0984

Fendiline hydrochloride 3 Publications Verification	Calcium Channel Ras STING Autophagy	Infection Cardiovascular Disease Cancer
Fendiline hydrochloride, a diphenylalkylamine type of antianginal agent, is an L-type calcium channel blocker (IC₅₀ of 17 µM). Fendiline hydrochloride is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras. Fendiline hydrochloride inhibits K-Ras plasma membrane localization (IC₅₀ of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. Fendiline hydrochloride is a STING agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10) .

HY-N0412

Sesamoside	PERK JNK TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Sesamoside is an orally active anti-inflammatory, anti-hypoxic and analgesic agent. Sesamoside inhibits the phosphorylation of ERK and JNK, downregulates NLRP3 expression, restricts the nuclear localization of P65, regulates AKR1B1 expression, and reduces the expression of TRPV1 gene in the spinal cord. Sesamoside reduces the production of TNF-α, IL-6, IL-1β, iNOS and NO, restores cellular metabolism and organ function, and alleviates cold and mechanical hyperalgesia. Sesamoside can be used in research related to septic shock, high-altitude pulmonary edema and neuropathic pain .

HY-123905

LIN28 inhibitor LI71	MicroRNA Parasite	Infection Cancer
LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC₅₀: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC₅₀: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum .

HY-W044764

2-Benzylsuccinic acid 1 Publications Verification DL-Benzylsuccinic acid	Carboxypeptidase	Neurological Disease Metabolic Disease
2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an orally active carboxypeptidase A and Nna1 inhibitor. 2-Benzylsuccinic acid reduces cold hyperalgesia. 2-Benzylsuccinic acid can be used for the researches of neuropathic pain, non-alcoholic steatohepatitis .

HY-B1173

(+)-Camphor 1 Publications Verification D-(+)-Camphor; (1R)-(+)-Camphor	Environmental Pollutants Bacterial	Neurological Disease Inflammation/Immunology Cancer
(+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1 channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-119190

PF-06445974	Phosphodiesterase (PDE)	Neurological Disease
PF-06445974, a promising positron emission tomography (PET) lead, has exquisite potency at PDE4B with an IC₅₀ <1 nM. The IC₅₀ values are 36, 4.7 and 17 nM for PDE4D, PDE4A and PDE4C, respectively. PF-06445974 has good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the "cold tracer" study .

HY-19976

RN-1747 5 Publications Verification	TRP Channel	Cardiovascular Disease Metabolic Disease
RN-1747 is a selective TRPV4 channel agonist, with EC₅₀ values of 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1747 acts as an antagonist of TRPM8, with an IC₅₀ of 4 μM. Topical cutaneous administration of RN-1747 induces hypothermia, increases tail heat loss via cutaneous vasodilation, and promotes cold-seeking behavior in rats. Intracerebroventricular administration of RN-1747 does not induce hypothermia in rats .

HY-B0984A

Fendiline 3 Publications Verification	Calcium Channel Ras STING Autophagy	Infection Cardiovascular Disease Cancer
Fendiline, a diphenylalkylamine type of antianginal agent, is an L-type calcium channel blocker (IC₅₀ of 17 µM). Fendiline is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras. Fendiline inhibits K-Ras plasma membrane localization (IC₅₀ of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. Fendiline is a STING agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10) .

HY-B0658A

Zinc acetate dihydrate, ACS, 98% Zinc(II) acetate dihydrate, ACS, 98%	Biochemical Assay Reagents	Others
Zinc acetate dihydrate, ACS, 98% (Zinc (II) acetate dihydrate, ACS, 98%) acts as a metal chelator and an intestinal metallothionein inducer. Zinc acetate dihydrate, ACS, 98% induces intestinal metallothionein synthesis and shortens the course of the common cold. Zinc acetate dihydrate, ACS, 98% is applicable to the research of copper metabolism disorder-related diseases, the common cold and Wilson's disease, as well as protein experiments .

HY-106856

Dimiracetam NT-11624	iGluR	Cancer
Dimiracetam is an orally active compound, with anti-neuropathic activity. Dimiracetam inhibits hypersensitivity and neurological alterations, and inhibits Sorafenib (HY-10201)-induced neuropathy in cold stimulation rat models .

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel	Microtubule/Tubulin	Cancer
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-W709856

Dodeca-2E,4E,8Z,10Z/E-N-tetraenoic acid isobutylamide	Influenza Virus	Infection
Dodeca-2E,4E,8Z,10Z/E-N-tetraenoic acid isobutylamide is a brain-penetrant substance and the main alkamide in Echinacea preparations, which might be used for research of common cold and various upper respiratory infections .

HY-125972

zr17-2	Keap1-Nrf2 Heme Oxygenase (HO)	Cardiovascular Disease Neurological Disease
zr17-2 is a cold inducible RNA-binding protein (CIRBP) agonist. zr17-2 has anti-inflammatory and anti-oxidant and can be used for the study of myocardial infarction. zr17-2 is a hypothermia mimetic molecule that reduces oxidative stress-induced retinal cell death .

HY-B0480A

Brompheniramine 2 Publications Verification (±)-Brompheniramine	Histamine Receptor mAChR Potassium Channel Sodium Channel Calcium Channel	Neurological Disease Inflammation/Immunology Endocrinology
Brompheniramine ((±)-Brompheniramine) is a potent and orally active antihistamine of the alkylamine class. Brompheniramine is a selective histamine H1 receptor antagonist with a K_d of 6.06 nM. Brompheniramine can block the hERG channels, calcium channels, and sodium channels with IC₅₀s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research .

HY-B0303R

Diphenhydramine (Standard)	Reference Standards Histamine Receptor Bacterial Endogenous Metabolite iGluR	Neurological Disease Inflammation/Immunology Cancer
Diphenhydramine (Standard) is the analytical standard of Diphenhydramine. This product is intended for research and analytical applications. Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) .

HY-B0984R

Fendiline hydrochloride (Standard)	Calcium Channel Ras STING Autophagy Reference Standards	Infection Cardiovascular Disease Cancer
Fendiline (hydrochloride) (Standard) is the analytical standard of Fendiline (hydrochloride). This product is intended for research and analytical applications. Fendiline hydrochloride, a diphenylalkylamine type of antianginal agent, is an L-type calcium channel blocker (IC50 of 17 µM). Fendiline hydrochloride is also a selective K-Ras inhibitor, and has no effect on H-Ras and N-Ras. Fendiline hydrochloride inhibits K-Ras plasma membrane localization (IC50 of 9.64 μM), inhibits K-Ras signal output and blocks the proliferation of pancreatic, colon, lung, and endometrial cancer cell lines expressing oncogenic mutant K-Ras. Fendiline hydrochloride is a STING agonist and is able to inhibit the growth of multiple refractory cold tumors (MC38, CT26 and B16F10) .

HY-N1369S

Menthol-d4	Isotope-Labeled Compounds Calcium Channel	Neurological Disease
Menthol-d₄ is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes .

HY-P991309

ZM-008	C-type Lectin-like Receptors (CTLRs)	Cancer
ZM-008 is an anti-LLT1 monoclonal antibody. ZM-008 blocks the interaction between LLT1 and CD161 on the surface of NK cells and T cells. ZM-008 restores anti-tumor immune activity, shifts the tumor microenvironment to an immune-responsive state, and recovers NK cell-mediated cytotoxicity against tumor cells, thereby reversing immunosuppression in immune-resistant "cold" tumors. ZM-008 is applicable to the research of immune-resistant solid tumors .

HY-N7536

Voacangine	TRP Channel	Others
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

HY-168758

Delta3,5-cholestadien-7-one	GABA Receptor	Neurological Disease
Delta3,5-cholestadien-7-one is an oxysterol and a negative allosteric modulator of GABAA receptors. Delta3,5-cholestadien-7-one reduces GABA-induced currents in HEK cells expressing α1β1γ2 or α4β3γ2 subunit-containing GABAA receptors with IC₅₀ values of 1.5 and 1 µM, respectively. Delta3,5-cholestadien-7-one reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons .

HY-107798

Potassium guaiacolsulfonate hemihydrate	Bacterial	Infection
Potassium guaiacolsulfonate hemihydrate is an orally active expectorant used for acute respiratory tract infections. Potassium guaiacolsulfonate hemihydrate helps loosen mucus and used for a cough caused by the common cold, infections or allergies in combination with other agents .

HY-N1369S1

Menthol-d2	Calcium Channel Isotope-Labeled Compounds	Neurological Disease
Menthol-d₂ is deuterated labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes .

HY-W322222

Ethyl (E,Z)-2,4-decadienoate	Sex Pheromone	Endocrinology
Ethyl (E,Z)-2,4-decadienoate is a pheromone that induces an electroshock response in male cold moths (Sensilla Auricillica) and can be isolated from host plants .

HY-B1173R

(+)-Camphor (Standard) D-(+)-Camphor (Standard); (1R)-(+)-Camphor (Standard)	Reference Standards Bacterial	Neurological Disease Inflammation/Immunology Cancer
(+)-Camphor (Standard) is the analytical standard of (+)-Camphor. This product is intended for research and analytical applications. (+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1 channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-117372

DFL23448	TRP Channel	Metabolic Disease
DFL23448 is a selective transient receptor potential melastatin-8 (TRPM8) antagonist. DFL23448 shows IC₅₀ values of 10 and 21 nM in hTRPM8 human embryonic kidney 293 cells activated by Cooling Agent 10 or cold. DFL23448 has limited activity (IC₅₀ >10 μM) at transient receptor potential vanilloids TRPV1, TRPA1, or TRPV4 or at various G protein-coupled receptors. DFL23448 can modify bladder function and reduce bladder overactivity in awake rats .

HY-123905A

LIN28 inhibitor LI71 enantiomer	Drug Isomer MicroRNA Parasite	Infection Cancer
LIN28 inhibitor LI71 enantiomer is the less active enantiomer of LIN28 inhibitor LI71 (HY-123905). LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC₅₀: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC₅₀: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum .

HY-W720736

Tinazoline	Drug Derivative	Cardiovascular Disease
Tinazoline, imidazole derivative, is a vasoconstrictor. Tinazoline can as nasal decongestant for the research of common cold .

HY-W044764R

2-Benzylsuccinic acid (Standard)	Reference Standards Carboxypeptidase	Neurological Disease Metabolic Disease
2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an orally active carboxypeptidase A and Nna1 inhibitor. 2-Benzylsuccinic acid reduces cold hyperalgesia. 2-Benzylsuccinic acid can be used for the researches of neuropathic pain, non-alcoholic steatohepatitis .

HY-107798R

Potassium guaiacolsulfonate hemihydrate (Standard)	Reference Standards Bacterial	Infection
Potassium guaiacolsulfonate (hemihydrate) (Standard) is the analytical standard of Potassium guaiacolsulfonate (hemihydrate). This product is intended for research and analytical applications. Potassium guaiacolsulfonate hemihydrate is an orally active expectorant used for acute respiratory tract infections. Potassium guaiacolsulfonate hemihydrate helps loosen mucus and used for a cough caused by the common cold, infections or allergies in combination with other agents .

HY-W099503

Heptyl acetate	Environmental Pollutants	Others
Heptyl acetate is a Miscellaneous product that can be isolated from the cold-pressed peel oil of Tosa-buntan (Citrus grandis Osbeck forma Tosa) .

HY-N9484S

Menthofuran-13C2	Drug Metabolite Isotope-Labeled Compounds	Others
Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-101309A

5-(Nonyloxy)tryptamine oxalate	5-HT Receptor	Cancer
5-(Nonyloxy)tryptamine oxalate, a high-affinity agonist for the 5-HTIDβ receptor, with an ED₅₀ value of 68 nM. 5-(Nonyloxy)tryptamine oxalate, exhibits antitumor growth activity in vivo and enhances the ability of T cells to target tumor cells .

HY-P5117

TAT-CIRP	Toll-like Receptor (TLR)	Neurological Disease
TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice .

HY-162463

Ir-UA	PD-1/PD-L1	Cancer
Ir-UA is an usnic acid-derived iridium(III) complex that enhances PD-L1 expression and converts "cold tumors" into "hot tumors." Ir-UA stimulates PD-L1 expression by explicitly regulating the PD-L1 transcription factor .

HY-B0480AR

Brompheniramine (Standard) (±)-Brompheniramine (Standard)	Reference Standards Histamine Receptor mAChR Potassium Channel Sodium Channel Calcium Channel	Neurological Disease Inflammation/Immunology Endocrinology
Brompheniramine (Standard) is the analytical standard of Brompheniramine. This product is intended for research and analytical applications. Brompheniramine ((±)-Brompheniramine) is a potent and orally active antihistamine of the alkylamine class. Brompheniramine is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research [4].

HY-B0480R

Brompheniramine maleate (Standard) (±)-Brompheniramine maleate (Standard)	Reference Standards Histamine Receptor mAChR Potassium Channel Sodium Channel Calcium Channel	Neurological Disease Inflammation/Immunology Endocrinology
Brompheniramine (maleate) (Standard) is the analytical standard of Brompheniramine (maleate). This product is intended for research and analytical applications. Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC₅₀s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research .

HY-176148

ZGL-18	Mitochondrial Metabolism	Metabolic Disease
ZGL-18 is an uncoupling protein 1 (UCP1)-inspired mitochondrial uncoupler. ZGL-18 activates brown adipocytes and reduces mitochondrial membrane potential .

HY-N1391R

10-Deacetyltaxol (Standard) 10-Deacetylpaclitaxel (Standard)	Reference Standards Microtubule/Tubulin	Cancer
10-Deacetyltaxol (Standard) is the analytical standard of 10-Deacetyltaxol. This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-N0060AR

Ferulic acid sodium (Standard) Coniferic acid sodium (Standard)	Reference Standards FGFR Endogenous Metabolite Reactive Oxygen Species (ROS)	Cardiovascular Disease Cancer
10-Deacetyltaxol (Standard) is the analytical standard of 10-Deacetyltaxol. This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

Cat. No.	Product Name	Type

HY-D0007

Blue Tetrazolium

Tetrazolium blue

Biochemical Assay Reagents

Blue Tetrazolium is a tetrazolium salt chromogenic dye that can be reduced to a dark blue formazan product. Blue Tetrazolium is applicable for assays such as succinate dehydrogenase activity detection and reducing sugar quantification. Blue Tetrazolium also serves as a novel corrosion inhibitor for cold-rolled steel in hydrochloric acid solutions. Blue Tetrazolium has a broad wavelength range (480-600 nm), with the maximum absorbance observed at 540 nm .

HY-B0658A

Zinc acetate dihydrate, ACS, 98%

Zinc(II) acetate dihydrate, ACS, 98%

Biochemical Assay Reagents

Zinc acetate dihydrate, ACS, 98% (Zinc (II) acetate dihydrate, ACS, 98%) acts as a metal chelator and an intestinal metallothionein inducer. Zinc acetate dihydrate, ACS, 98% induces intestinal metallothionein synthesis and shortens the course of the common cold. Zinc acetate dihydrate, ACS, 98% is applicable to the research of copper metabolism disorder-related diseases, the common cold and Wilson's disease, as well as protein experiments .

Cat. No.	Product Name	Target	Research Area

HY-P5117

TAT-CIRP	Toll-like Receptor (TLR)	Neurological Disease
TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991097

Pumitamig PM-8002; BNT-327	VEGFR PD-1/PD-L1	Cancer
Pumitamig (PM-8002, BNT-327) is a bispecific antibody targeting PD-L1 and VEGF-A, with immune activation and anti-angiogenic activities. By binding to PD-L1, Pumitamig restores the function of effector T cells, while neutralizing VEGF-A in the tumor microenvironment to reverse its inhibition on the infiltration and activation of immune cells and normalize tumor blood vessels. Pumitamig can also be combined with various ADCs targeting TROP2, B7H3, HER2, HER3 for the research of advanced/metastatic solid tumors, including non-small cell lung cancer, ovarian cancer, triple-negative breast cancer, cervical cancer, etc. Pumitamig also exhibits potential efficacy in "cold" tumors with low PD-L1 expression that are insensitive to immunotherapy .

HY-P99050

Sutimlimab BIVV009; IPN-009; TNT009	Complement System	Cardiovascular Disease Inflammation/Immunology
Sutimlimab is a humanized monoclonal IgG4 antibody. Sutimlimab inhibits complement protein component 1, s subcomponent (C1s). Sutimlimab blocks C3 and C4 activation. Sutimlimab can be used for the research of cold agglutinin disease and complement-mediated hemolytic uremic syndrome .

HY-P991309

ZM-008	C-type Lectin-like Receptors (CTLRs)	Cancer
ZM-008 is an anti-LLT1 monoclonal antibody. ZM-008 blocks the interaction between LLT1 and CD161 on the surface of NK cells and T cells. ZM-008 restores anti-tumor immune activity, shifts the tumor microenvironment to an immune-responsive state, and recovers NK cell-mediated cytotoxicity against tumor cells, thereby reversing immunosuppression in immune-resistant "cold" tumors. ZM-008 is applicable to the research of immune-resistant solid tumors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0303

Diphenhydramine 5+ Cited Publications	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Histamine Receptor Bacterial Endogenous Metabolite iGluR
Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) .

HY-116003

12,13-DiHOME	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders .

HY-N0412

Sesamoside	Structural Classification Iridoids Classification of Application Fields Terpenoids Labiatae Phaseolus lunatus L. Plants Inflammation/Immunology Disease Research Fields Source Classification	PERK JNK TNF Receptor Interleukin Related
Sesamoside is an orally active anti-inflammatory, anti-hypoxic and analgesic agent. Sesamoside inhibits the phosphorylation of ERK and JNK, downregulates NLRP3 expression, restricts the nuclear localization of P65, regulates AKR1B1 expression, and reduces the expression of TRPV1 gene in the spinal cord. Sesamoside reduces the production of TNF-α, IL-6, IL-1β, iNOS and NO, restores cellular metabolism and organ function, and alleviates cold and mechanical hyperalgesia. Sesamoside can be used in research related to septic shock, high-altitude pulmonary edema and neuropathic pain .

HY-B1173

(+)-Camphor 1 Publications Verification D-(+)-Camphor; (1R)-(+)-Camphor	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Other Diseases Plants Lauraceae Cinnamomum camphora Disease Research Fields Source Classification	Environmental Pollutants Bacterial
(+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1 channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel	Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus wallichiana Zucc. Source Classification Cancer	Microtubule/Tubulin
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-W709856

Dodeca-2E,4E,8Z,10Z/E-N-tetraenoic acid isobutylamide	Alkaloids Other Alkaloids Plants Compositae Echinacea angustifolia DC. Source Classification	Influenza Virus
Dodeca-2E,4E,8Z,10Z/E-N-tetraenoic acid isobutylamide is a brain-penetrant substance and the main alkamide in Echinacea preparations, which might be used for research of common cold and various upper respiratory infections .

HY-B0303R

Diphenhydramine (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Histamine Receptor Bacterial Endogenous Metabolite iGluR
Diphenhydramine (Standard) is the analytical standard of Diphenhydramine. This product is intended for research and analytical applications. Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) .

HY-N7536

Voacangine	Alkaloids other families Classification of Application Fields Other Diseases Plants Disease Research Fields Indole Alkaloids Source Classification	TRP Channel
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

HY-W322222

Ethyl (E,Z)-2,4-decadienoate	Natural Products Animals Source Classification	Sex Pheromone
Ethyl (E,Z)-2,4-decadienoate is a pheromone that induces an electroshock response in male cold moths (Sensilla Auricillica) and can be isolated from host plants .

HY-B1173R

(+)-Camphor (Standard) D-(+)-Camphor (Standard); (1R)-(+)-Camphor (Standard)	Structural Classification Other Monoterpenes Terpenoids Plants Lauraceae Cinnamomum camphora Source Classification	Reference Standards Bacterial
(+)-Camphor (Standard) is the analytical standard of (+)-Camphor. This product is intended for research and analytical applications. (+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1 channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-W099503

Heptyl acetate	Structural Classification Natural Products Source Classification	Environmental Pollutants
Heptyl acetate is a Miscellaneous product that can be isolated from the cold-pressed peel oil of Tosa-buntan (Citrus grandis Osbeck forma Tosa) .

HY-N1391R

10-Deacetyltaxol (Standard) 10-Deacetylpaclitaxel (Standard)	Structural Classification Terpenoids Taxaceae Diterpenoids Plants Taxus wallichiana Zucc. Source Classification	Reference Standards Microtubule/Tubulin
10-Deacetyltaxol (Standard) is the analytical standard of 10-Deacetyltaxol. This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-N0060AR

Ferulic acid sodium (Standard) Coniferic acid sodium (Standard)	Structural Classification Monophenols other families Simple Phenylpropanols Phenols Phenylpropanoids Plants Endogenous metabolite Source Classification	Reference Standards FGFR Endogenous Metabolite Reactive Oxygen Species (ROS)
10-Deacetyltaxol (Standard) is the analytical standard of 10-Deacetyltaxol. This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-N7697BR

Chitobiose dihydrochloride (Standard)	Structural Classification Microorganisms Saccharides Source Classification	Reference Standards Others
Gibberellic acid (Standard) is the analytical standard of Gibberellic acid. This product is intended for research and analytical applications. Gibberellic Acid is named after the fungus Gibberella fujikuroi. Gibberellic Acid regulates processes in plant development and growth, including seed development and germination, stem and root growth, cell division, and flowering time. Gibberellic Acid also improves plant response to growth stress caused by various environmental stresses, such as cold stress, drought stress, heavy metal stress, etc. Gibberellic Acid also causes increased lipid peroxidation and fluctuations in the antioxidant defense system in rats .

HY-N18736

Marshmallow extract	Structural Classification Extract	Others
Marshmallow extract is a natural compound, finding application in the research of respiratory ailments, including coughs, colds and sore throats.

HY-W099503R

Heptyl acetate (Standard)	Structural Classification Natural Products Source Classification	Others Reference Standards
Heptyl acetate (Standard) is the analytical standard of Heptyl acetate (HY-W099503). This product is intended for research and analytical applications. Heptyl acetate is a Miscellaneous product that can be isolated from the cold-pressed peel oil of Tosa-buntan (Citrus grandis Osbeck forma Tosa) .

HY-N17566

Eukovoside	Structural Classification Polysaccharides Terpenoids Sesquiterpenes Orobanchaceae Plants Euphrasia regelii Wettst. Saccharides Source Classification	Bacterial Histamine Receptor
Eukovoside is a cinnamic acid derivative found in Euphrasia regelii with anti-inflammatory, antioxidant, antibacterial, antiallergic, and antihistamine activity. Eukovoside can be used for the research of hyperglycemic diseases, eye inflammation, upper respiratory passages inflammation, hay fever, conjunctivitis, colds, influenza, sinusitis .

HY-N17784

Peiioside A	Structural Classification Simple Phenylpropanols Labiatae Phenylpropanoids Plants Callicarpa dolichophylla Merr. Source Classification	Others
Peiioside A is a phenylethanoid glycoside compound that can be isolated from the leaves and stems of Callicarpa longissima. Callicarpa longissima has traditional medicinal uses for treating colds, coughs, arthritis, and bleeding, and can be used in the research of anti-inflammatory and antibacterial agents, as well as in neuroprotection-related fields.

HY-N16683

Galangin 5-methyl ether	Structural Classification Flavonols Flavonoids Animals Source Classification	Others
Galangin 5-methyl ether is a potentially active compound that can be naturally extracted from propolis. Propolis is a resinous substance collected by bees from the leaf buds and bark cracks of various trees, enriched with saliva and enzyme secretions. The propolis extract containing Galangin 5-methyl ether has pharmacological activities such as antibacterial, antiviral, and anti-inflammatory effects, and can be used in research related to cold syndromes, skin diseases, and oral inflammation .

HY-N18649

Rosa canina extract	Structural Classification Extract	Others
Rosa canina extract, derived from the wild rose (often known as rose hip), is rich in vitamin C, flavonoids, carotenoids, and essential fatty acids, contributing to its numerous health benefits. The extract is primarily known for its anti-inflammatory, antioxidant, and immune-boosting properties. Rosa canina extract is commonly used to boost the immune system, particularly during cold and flu seasons, due to its high vitamin C content. It also has joint health benefits, as it helps reduce inflammation and pain in conditions like arthritis. The extract's antioxidant properties help protect cells from oxidative stress and may contribute to skin health by promoting collagen synthesis, reducing the appearance of wrinkles, and supporting overall skin elasticity.

Species:	Human (6) Mouse (2)
Tag:	SUMO (1) His (5) Tag Free (2) Fc (1)
Source:	HEK293 (2) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73063

	Fibronectin Protein, Human (HEK293, His) 1 Publications Verification Fibronectin; FN; cold-insoluble globulin; CIG; FN1	Human	HEK293
	Fibronectin binds collagen, fibrin, heparin, DNA, and actin. It is involved in cell adhesion, motility, opsonization, wound healing and maintenance of cell shape. Fibronectin Protein, Human (HEK293, His) is the recombinant human-derived Fibronectin protein, expressed by HEK293 , with C-His labeled tag.

HY-P70593

	Fibronectin Protein, Human Maximum Cited Publications 9 Publications Verification NovoNectin; Fibronectin; FN; cold-insoluble globulin; CIG; FN; Fibronectin 1	Human	E. coli
	Fibronectin binds collagen, fibrin, heparin, DNA, and actin. It is involved in cell adhesion, motility, opsonization, wound healing and maintenance of cell shape. Fibronectin Protein, Human is the recombinant human-derived Fibronectin protein, expressed by E. coli, with tag free.

HY-P76261

	CIRBP Protein, Human (His) 1 Publications Verification cold-inducible RNA-binding protein A; XCIRP; cirbp-a; CIRP-1	Human	E. coli
	CIRBP is a cold-induced mRNA-binding protein that plays a key role in cellular responses to genotoxic stress, exerting a protective effect by stabilizing transcripts of genes critical for cell survival. As a translation activator, CIRBP appears to be critical for cold-induced inhibition of cell proliferation. CIRBP Protein, Human (His) is the recombinant human-derived CIRBP protein, expressed by E. coli , with N-His labeled tag.

HY-P70593G

	GMP Fibronectin Protein, Human NovoNectin; Fibronectin; FN; cold-insoluble globulin; CIG; FN; Fibronectin 1	Human	E. coli
	Fibronectin binds collagen, fibrin, heparin, DNA, and actin. It is involved in cell adhesion, motility, opsonization, wound healing and maintenance of cell shape. GMP Fibronectin Protein, Human is the recombinant human-derived GMP Fibronectin protein, expressed by E. coli, with tag free.

HY-P703742

	Fibronectin Protein, Human (91a.a, HEK293, hFc) Fibronectin; FN1; cold-insoluble globulin (CIG); FN	Human	HEK293
	Fibronectin (1266-1356) Protein, Human (HEK293, hFc) is the recombinant human-derived Fibronectin protein, expressed by HEK293, with C-hFc tag.

HY-P704032

	CSDE1 Protein, Mouse (His) cold shock domain-containing protein E1; Csde1; D3Jfr1	Mouse	E. coli
	CSDE1 Protein, Mouse (His) is the recombinant mouse-derived CSDE1 protein, expressed by E. coli, with C-6*His tag.

HY-P790108

	NLRP3 Protein, Human (His) Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1; NLRP3; NALP3; PYPAF1; CIAS1	Human	E. coli
	The NLRP3 protein acts as a sensor in the NLRP3 inflammasome, which is activated in response to membrane defects. It forms a complex with CASP1 and PYCARD/ASC, promotes the release of IL1B, IL18 and GSDMD, and induces pyroptosis. NLRP3 Protein, Human (His) is the recombinant human-derived NLRP3, expressed by E. coli, with C-6*His labeled tag.

HY-P71598

	NLRP3 Protein, Mouse (His-SUMO) 1 Publications Verification Nlrp3; Cias1; Mmig1; Nalp3; Pypaf1; NACHT; LRR and PYD domains-containing protein 3; cold autoinflammatory syndrome 1 protein homolog; Cryopyrin; Mast cell maturation-associated-inducible protein 1; PYRIN-containing APAF1-like protein 1	Mouse	E. coli
	The NLRP3 protein acts as a sensor in the NLRP3 inflammasome, which is activated in response to membrane defects caused by pathogens or damage signals. It assembles the inflammasome complex, including NLRP3, CASP1, and PYCARD/ASC. NLRP3 Protein, Mouse (His-SUMO) is the recombinant mouse-derived NLRP3 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

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Species
Source
Tag
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Cat. No.	Product Name	Chemical Structure

HY-N1369S

Menthol-d4
Menthol-d₄ is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes .

HY-N1369S1

Menthol-d2
Menthol-d₂ is deuterated labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes .

HY-N9484S

Menthofuran-13C2

Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

Host:	Mouse (1) Rabbit (3)
Reactivity:	Human (4) Rat (4) Mouse (4)
Application:	IHC-P (4) ICC/IF (4) IP (1) IHC-F (1) WB (4) ELISA (2)
Isotype:	IgG (2) IgG1 (1) IgG,IgG/Kappa (1)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (4) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80674

	Fibronectin Antibody (YA762) 1 Publications Verification FN1; FN; Fibronectin; FN; cold-insoluble globulin; CIG	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Fibronectin Antibody (YA762) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Fibronectin.

HY-P86415

	Fibronectin Antibody (YA6107) FN1; FN; Fibronectin; FN; cold-insoluble globulin; CIG	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Fibronectin Antibody (YA6107) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Fibronectin.

HY-P810728

	NLRP3 Antibody (YA9972) C1orf7, CIAS1, NALP3, PYPAF1, NLRP3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, CLR1.1	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	NLRP3 Antibody (YA9972) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to NLRP3 Antibody.

HY-P86650

	NLRP3 Antibody (YA6342) NLRP3; C1orf7; CIAS1; NALP3; PYPAF1; NACHT, LRR and PYD domains-containing protein 3; Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1CLR1.1; cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	NLRP3 Antibody (YA6342) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NLRP3.

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