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Results for "

covalent dimerization

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

3

Fluorescent Dyes

2

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-124700
    LYPLAL1-IN-1
    1 Publications Verification

    		 Cyclic GMP-AMP Synthase STING PD-1/PD-L1 Epoxide Hydrolase Metabolic Disease
    LYPLAL1-IN-1 (compound 11) is a selective, covalent, and irreversible inhibitor of the lysophospholipase-like enzyme LYPLAL1 (IC50 = 6 nM). LYPLAL1-IN-1 shows selectivity against other serine hydrolases such as carboxylesterase CES1 (IC50 > 50 μM for CES1). LYPLAL1-IN-1 inhibits the depalmitoylation function of LYPLAL1, blocking its depalmitoylation modification of cyclic GMP-AMP synthase (cGAS), thereby promoting cGAS dimerization and activation, and initiating the cGAS-STING pathway-mediated innate immune response. LYPLAL1-IN-1 can enhance DNA-induced type I interferon production, upregulate PD-L1 expression in tumor cells, and promote the accumulation of tumor-infiltrating CD8 + T cells, with the core function of strengthening the anti-tumor immune response. LYPLAL1-IN-1 is primarily used in tumor immunology research, especially in combination with PD-1/PD-L1 inhibitors .
    LYPLAL1-IN-1
  • HY-131015
    HaXS8

    		Biochemical Assay Reagents Others
    HaXS8 is a dimerizer that can promote a covalent and irreversible intracellular dimerization of HaloTag and SNAP-tagged proteins of interest. HaXS8 does not interfere with PI3K/mTOR signaling .
    HaXS8
  • HY-P3223A
    Biphalin acetate

    		Opioid Receptor Neurological Disease
    Biphalin acetate, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores.Biphalin acetate has high affinity for opioid receptors. Biphalin acetate shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin acetate is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .
    Biphalin acetate
  • HY-P3223
    Biphalin TFA

    		Opioid Receptor Neurological Disease
    Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .
    Biphalin TFA
  • HY-D2995
    CoDi3

    		Biochemical Assay Reagents Others
    CoDi3 is a covalent dimerization inducer. CoDi3 can specifically, covalently and irreversibly induce the dimerization of two proteins that have been fused with O6-alkylguanine-DNA alkyltransferase (AGT, also known as SNAP-tag) in living cells. CoDi3 can act as a "sensor" for protein-protein interactions .
    CoDi3
  • HY-D2935
    CoDi2

    		Biochemical Assay Reagents Others
    CoDi3 is a covalent dimerization inducer. CoDi3 can specifically, covalently and irreversibly induce the dimerization of two proteins that have been fused with O6-alkylguanine-DNA alkyltransferase (AGT, also known as SNAP-tag) in living cells. CoDi3 can act as a "sensor" for protein-protein interactions .
    CoDi2
  • HY-D2981
    CoDi1

    		Biochemical Assay Reagents Others
    CoDi1 is an effective chemical crosslinking agent. CoDi1 can achieve covalent and irreversible dimerization of AGT/SNAP tag fusion proteins in living cells .
    CoDi1

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