Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
excision
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "excision" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: O-Methylhydroxylamine hydrochloride; TRC-102 hydrochloride
Target:
Forschungsgebiete:
Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents .
1
1 Cited Publications
Synonyms: Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243
Target:
Forschungsgebiete:
Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity .
Art. -Nr.: HY-Y0958S
CAS. Nr.: 110220-55-8
Synonyms: O-Methylhydroxylamine-d3 hydrochloride
Target:
Forschungsgebiete:
ERCC1-XPF-IN-2 is a potent ERCC1-XPF endonuclease inhibitor with an IC50 value of 0.6 μM. ERCC1-XPF-IN-2 shows activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays .
Art. -Nr.: HY-W011425
CAS. Nr.: 6419-19-8
Synonyms: Nitrilotris(methylenephosphonic acid)
Target:
Forschungsgebiete:
NTPO (Nitrilotris methylenephosphonic acid) is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO are abrogated by base excision repair (BER) but not nucleotide excision repair (NER) .
Art. -Nr.: HY-175466
Target:
Forschungsgebiete:
BER-IN-1 is a base excision repair (BER) inhibtor, targeting DNA abasic sites. BER-IN-1 cleaves abasic sites via β- and β,δ-elimination mechanisms, disrupts the base excision repair (BER) pathway and leads to DNA double-strand breaks (DSBs). BER-IN-1 can enhance the effectiveness of the PARP inhibitor Olaparib (HY-10162) in homologous recombination (HR)-proficient cancer cells (MDA-MB-231, HeLa, and SKOV3). BER-IN-1 induces an S-phase arrest and apoptosis companied with Olaparib (HY-10162). BER-IN-1 can be used for the research of cancer, such as breast, cervical and ovarian cancer .
Art. -Nr.: HY-W011425A
CAS. Nr.: 7611-50-9
Synonyms: Nitrilotris(methylenephosphonic acid), trisodium salt
Forschungsgebiete:
Methoxyamine hydrochloride (Standard) is the analytical standard of Methoxyamine hydrochloride. This product is intended for research and analytical applications. Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents .
Art. -Nr.: HY-15794G
CAS. Nr.: 108852-90-0
Synonyms: Methoxymorpholinyl doxorubicin (GMP); FCE 23762 (GMP); PNU 152243 (GMP)
Art. -Nr.: HY-184013
Target:
Forschungsgebiete:
SU0617 is a selective SMUG1 inhibitor with a human IC50 of 1.5 μM. SU0617 inhibits base excision repair activity of SMUG1, including excision of modified and damaged pyrimidines from DNA. SU0617 can be used for the research of breast cancer .
Art. -Nr.: HY-P810462
Synonyms: ERCC8, ERCC excision Repair 8, CSA Ubiquitin Ligase Complex Subunit, CSA, CKN1, excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8, excision Repair Cross-Complementation Group 8, Cockayne Syndrome WD Repeat Protein CSA, DNA excision Repair Protein ERCC-8, Cockayne Syndrome WD-Repeat Protein CSA, Cockayne Syndrome 1 (Classical), UVSS2
Art. -Nr.: HY-W974306
CAS. Nr.: 1230-77-9
Target:
Forschungsgebiete:
DML3, a 5-methylcytosine DNA glycosylase, is a DNA demethylating agent. DML3 specifically recognizes and excises 5-methylcytosine (5-meC) from DNA through a base excision repair mechanism. DML3 is promising for research of plant epigenetic regulation and cancers .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
