BER-IN-1
BER-IN-1 is a base excision repair (BER) inhibtor, targeting DNA abasic sites. BER-IN-1 cleaves abasic sites via β- and β,δ-elimination mechanisms, disrupts the base excision repair (BER) pathway and leads to DNA double-strand breaks (DSBs). BER-IN-1 can enhance the effectiveness of the PARP inhibitor Olaparib (HY-10162) in homologous recombination (HR)-proficient cancer cells (MDA-MB-231, HeLa, and SKOV3). BER-IN-1 induces an S-phase arrest and apoptosis companied with Olaparib (HY-10162). BER-IN-1 can be used for the research of cancer, such as breast, cervical and ovarian cancer.
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- 화학식: C13H17N5
- 분자량:243.31
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
제품 설명
IC50 & Target
[1]|
PARP-1 |
In Vitro
BER-IN-1 (Compound BA-6) shows IC50 of 10.92 μM for MDA-MB-231, 6.37 μM for HeLa, 7.76 μM for SKOV3 and 5.53 μM for OVCAR3BRCA1−/− cells[1].
BER-IN-1 (0.7-50 μM, 24-72 h) significantly reduces cell viability companied with Olaparib (HY-10162) in MDA-MB-231, HeLa and OVCAR3BRCA1−/− cells[1].
BER-IN-1 (5-10 μM) inhibits colony formation companied with Olaparib in MDA-MB-231 and HeLa cancer cells[1].
BER-IN-1 (5-50 μM) increased prominent β-elimination products and induces DNA DSBs companied with Olaparib in MDA-MB-231 and HeLa cancer cells[1].
BER-IN-1 (5-10 μM, 24 h) induces S-phase arrest and apoptosis companied with Olaparib in MDA-MB-231 and HeLa cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231, HeLa and OVCAR3BRCA1−/− cells
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Concentration:0.7, 1.5, 3.1, 6.2, 12.5, 25 and 50 μM
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Incubation Time:24 or 72 h, companied with Olaparib (0.15-200 μM)
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Result:Significantly reduced cell viability.
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Cell Line:MDA-MB-231 and HeLa cancer cells
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Concentration:5 and 10 μM
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Incubation Time:24 h, companied with Olaparib (5-10 μM)
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Result:Increased cells in the G2/M phase and S-phase arrest.
Chemical Information
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분자량 243.31
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화학식 C13H17N5
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SMILES
NC1=CC=C2N=C(N(C)CCCN3C)C3=NC2=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BER-IN-1 Related Classifications
HY-175466 Related Classifications
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