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Results for "

explants

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADAMTS (1) Akt (1) Apoptosis (6) Bacterial (2) Bcl-2 Family (1) Biochemical Assay Reagents (2) Caspase (2) Collagen (2) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Metabolite (1) Endogenous Metabolite (1) Environmental Pollutants (1) ERK (1) Exosomes (1) FOXO (1) Fungal (1) JAK (1) JNK (2) Lipase (1) MMP (2) mTOR (1) NF-κB (1) NO Synthase (2) PARP (1) PPAR (1) Proton Pump (1) Reactive Oxygen Species (ROS) (2) RIP kinase (2) SOD (1) STAT (1) TNF Receptor (1) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (8) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (11) Neurological Disease (3)

By Targets:

ADAMTS (1)

Akt (1)

Apoptosis (6)

Bacterial (2)

Bcl-2 Family (1)

Biochemical Assay Reagents (2)

Caspase (2)

Collagen (2)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Drug Metabolite (1)

Endogenous Metabolite (1)

Environmental Pollutants (1)

ERK (1)

Exosomes (1)

FOXO (1)

Fungal (1)

JAK (1)

JNK (2)

Lipase (1)

MMP (2)

mTOR (1)

NF-κB (1)

NO Synthase (2)

PARP (1)

PPAR (1)

Proton Pump (1)

Reactive Oxygen Species (ROS) (2)

RIP kinase (2)

SOD (1)

STAT (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (2)

By Research Areas:

Cancer (8)

Cardiovascular Disease (2)

Infection (2)

Inflammation/Immunology (11)

Neurological Disease (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W145499

Zinc Gluconate 1 Publications Verification	PPAR NF-κB Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Zinc Gluconate is a zinc supplement in the form of a gluconate salt, which plays a role in various physiological processes such as immune function, wound healing, and olfaction. Zinc Gluconate has a LD₅₀ of 39.6 mg/kg in mice (Tail vein injection). Zinc Gluconate can be used in the research of inflammation, zinc deficiency, colds, cancer, and nutritional supplements .

HY-136979

RBN012759 Maximum Cited Publications 13 Publications Verification	PARP	Inflammation/Immunology Cancer
RBN012759 is a potent, selective and orally active inhibitor of PARP14, with an IC₅₀ of <3 nM. RBN012759 displays 300-fold selectivity over the monoPARPs and 1000-fold selectivity over the polyPARPs. RBN012759 decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants .

HY-W051140

Silver sulfate Disilver sulfate, 99%	Environmental Pollutants Biochemical Assay Reagents	Others
Silver sulfate acts as an ethylene inhibitor and a shoot regeneration promoter. Silver sulfate promotes shoot proliferation in explants of the cherry rootstock CAB-6P. Silver sulfate is applicable to studies on the optimization of micropropagation for cherry rootstocks .

HY-P10739

WYRGRL	Exosomes Collagen	Inflammation/Immunology
WYRGRL is a selective, high-affinity collagen type II-binding peptide with a IC₅₀ of 140 nM. Collagen type II is the most abundant and specific structural protein in the extracellular matrix of articular cartilage. WYRGRL can precisely target small-molecule compounds such as Dexamethasone (HY-14648) and nanocarrier-engineered exosomes to cartilage, significantly enhancing their therapeutic effects on osteoarthritis .

HY-112038A

GSK2983559 2 Publications Verification	RIP kinase	Inflammation/Immunology
GSK2983559 is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples .

HY-112038

GSK2983559 free acid 2 Publications Verification	RIP kinase	Inflammation/Immunology
GSK2983559 free acid (compound 3) is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid can block many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples .

HY-N4102

5,7-Dihydroxy-4-methylcoumarin	Apoptosis JNK FOXO Reactive Oxygen Species (ROS) Caspase	Neurological Disease
5,7-Dihydroxy-4-methylcoumarin is an antioxidant. 5,7-Dihydroxy-4-methylcoumarin protects mouse cochlear hair cells from Cisplatin-induced damage, enhances cell viability and inhibits apoptosis. 5,7-Dihydroxy-4-methylcoumarin downregulates phosphorylated JNK levels, increases the ratio of phosphorylated FoxO1 to total FoxO1, scavenges free radicals, reduces ROS accumulation, maintains mitochondrial membrane potential and alleviates mitochondrial dysfunction. 5,7-Dihydroxy-4-methylcoumarin downregulates the expression of caspase-3 and improves cell viability. 5,7-Dihydroxy-4-methylcoumarin can be used in studies related to ototoxicity .

HY-112642

9-Methoxycanthin-6-one	TNF Receptor	Cancer
9-Methoxycanthin-6-one, a canthin-6-one alkaloid, is present in intact plant parts and in callus tissues of different explants. 9-Methoxycanthin-6-one shows anti-tumor activity, inhibits LPS-induced TNF-α and IL-1β .

HY-113438

15(S)-HPETE	Drug Metabolite Bcl-2 Family Akt Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies .

HY-19527

IST5-002 1 Publications Verification N6-Benzyladenosine-5'-phosphate	STAT Apoptosis	Cancer
IST5-002, a potent Stat5a/b inhibitor, selectively inhibits transcriptional activity of Stat5a/b (IC₅₀s: 1.5 μM for Stat5a, 3.5 μM for Stat5b). IST5-002 inducs cell apoptotic and death of prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used in the research of prostate cancer and chronic myeloid leukemia (CML) .

HY-N3138

Ombuoside	Bacterial Apoptosis Reactive Oxygen Species (ROS) ERK JNK Caspase SOD Fungal	Infection Neurological Disease
Ombuoside has antioxidant properties, inhibiting ROS production and apoptosis. Ombuoside exerts neuroprotective effects through the ERK-JNK-caspase-3 system. Ombuoside promotes Dopamine biosynthesis through TH and CREB activation. Ombuoside exhibits antimicrobial activity against several Gram-positive and Gram-negative bacteria, as well as Candida albicans

HY-103702

TIP48/49-IN-1	Proton Pump DNA/RNA Synthesis Apoptosis	Inflammation/Immunology Cancer
TIP48/49-IN-1 is an orally active, specific RUVBL1/2 (TIP48/49) ATPase inhibitor with an IC₅₀ of 59 nM against purified RUVBL1/2. TIP48/49-IN-1 inhibits the DNA replication process, leading to S-phase arrest. TIP48/49-IN-1 induces apoptosis. TIP48/49-IN-1 can be used for the research of non-small cell lung cancer (NSCLC) cells .

HY-N14827

Xanthofulvin SM-216289	Drug Derivative	Neurological Disease
Xanthofulvin (SM-216289) is an inhibitor of semaphorin 3A. Xanthofulvin blocks its binding to receptors, inhibits growth cone collapse, and accelerates olfactory nerve regeneration in rats in vivo. Xanthofulvin can be used in studies related to traumatic neuronal injury .

HY-165255

N-Isobutyl decanamide	Biochemical Assay Reagents NO Synthase	Others
N-Isobutyl decanamide is a plant growth regulator. N-Isobutyl decanamide promotes the development of adventitious roots in hypocotyl explants of A. thaliana and lateral roots in taproot explants. N-Isobutyl decanamide induces the accumulation of NO in the proliferative sites of adventitious roots .

HY-100518A

T 26c sodium	MMP	Inflammation/Immunology
T26c sodium is a potent and selective MMP13 inhibitor with IC₅₀ value of 6.9 pM. T26c sodium can inhibit the degradation of bovine nasal septal cartilage explants .

HY-105140

CPA 926	MMP	Inflammation/Immunology
CPA 926 is a prodrug of Esculetin (HY-N0284) and is orally active. CPA 926 can inhibit the production of MMP in cartilage explants. CPA 926 can be used for the research of inflammation, such as experimental osteoarthritis .

HY-W419331

Methionyl-methionine DL-Methionyl-DL-methionine	JAK mTOR	Cancer
Methionylmethionine (Met-Met) significantly promotes α-s1 casein (α_S1-CN) expression in the mammary explants by enhancing intracellular substrate availability and activating JAK2-STAT5 and mTOR-mediated signaling pathways .

HY-174313

Antibacterial agent 284	Bacterial Toll-like Receptor (TLR) Collagen	Infection Inflammation/Immunology
Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC₅₀: 0.96 μM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-κB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires' disease research .

HY-N15491

2-Deoxyecdysone	Endogenous Metabolite	Others
2-Deoxyecdysone is a circulating ecdysteroid found in Z. atratus and functions as a prohormone during the development of some insects .

HY-P992358

GSK2394002	ADAMTS	Cardiovascular Disease
GSK2394002 is an antibody inhibitor targeting ADAMTS-4 and ADAMTS-5, with cartilage-penetrating ability following systemic administration. GSK2394002 inhibits the release of aggrecan-derived neoepitopes and reduces cartilage degradation, exhibiting the potential to relieve pain, alleviate hyperalgesia and inhibit the progression of joint damage. GSK2394002 also induces potentially irreversible cardiovascular effects such as increased mean arterial pressure and myocardial ischemia in cynomolgus monkeys .

HY-183647

iNOs-IN-9	NO Synthase	Inflammation/Immunology
iNOs-IN-9 (Compound 10) is a selective inducible nitric oxide synthase (iNOS) inhibitor with an IC₅₀ of 82 nM against hiNOS. iNOs-IN-9 reduces cytokine-induced inflammatory responses and cell necrosis in inflammatory cell models. iNOs-IN-9 can be used for research related to psoriasis .

HY-181986

ERX-208	Lipase Apoptosis	Cancer
ERX-208 is an anticancer agent that induces endoplasmic reticulum stress by targeting lysosomal acid lipase A (LIPA), ultimately leading to cancer cell apoptosis. ERX-208 can be used in ovarian cancer research .

Cat. No.	Product Name	Target	Research Area

HY-P10739

WYRGRL	Exosomes Collagen	Inflammation/Immunology
WYRGRL is a selective, high-affinity collagen type II-binding peptide with a IC₅₀ of 140 nM. Collagen type II is the most abundant and specific structural protein in the extracellular matrix of articular cartilage. WYRGRL can precisely target small-molecule compounds such as Dexamethasone (HY-14648) and nanocarrier-engineered exosomes to cartilage, significantly enhancing their therapeutic effects on osteoarthritis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992358

GSK2394002	ADAMTS	Cardiovascular Disease
GSK2394002 is an antibody inhibitor targeting ADAMTS-4 and ADAMTS-5, with cartilage-penetrating ability following systemic administration. GSK2394002 inhibits the release of aggrecan-derived neoepitopes and reduces cartilage degradation, exhibiting the potential to relieve pain, alleviate hyperalgesia and inhibit the progression of joint damage. GSK2394002 also induces potentially irreversible cardiovascular effects such as increased mean arterial pressure and myocardial ischemia in cynomolgus monkeys .

5,7-Dihydroxy-4-methylcoumarin	Infection Structural Classification other families Classification of Application Fields Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification	Apoptosis JNK FOXO Reactive Oxygen Species (ROS) Caspase
5,7-Dihydroxy-4-methylcoumarin is an antioxidant. 5,7-Dihydroxy-4-methylcoumarin protects mouse cochlear hair cells from Cisplatin-induced damage, enhances cell viability and inhibits apoptosis. 5,7-Dihydroxy-4-methylcoumarin downregulates phosphorylated JNK levels, increases the ratio of phosphorylated FoxO1 to total FoxO1, scavenges free radicals, reduces ROS accumulation, maintains mitochondrial membrane potential and alleviates mitochondrial dysfunction. 5,7-Dihydroxy-4-methylcoumarin downregulates the expression of caspase-3 and improves cell viability. 5,7-Dihydroxy-4-methylcoumarin can be used in studies related to ototoxicity .

9-Methoxycanthin-6-one	Alkaloids other families Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Source Classification Cancer	TNF Receptor
9-Methoxycanthin-6-one, a canthin-6-one alkaloid, is present in intact plant parts and in callus tissues of different explants. 9-Methoxycanthin-6-one shows anti-tumor activity, inhibits LPS-induced TNF-α and IL-1β .

Ombuoside	Infection Flavonols Flavonoids Classification of Application Fields Cucurbitaceae Phenols Polyphenols Plants Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields Source Classification	Bacterial Apoptosis Reactive Oxygen Species (ROS) ERK JNK Caspase SOD Fungal
Ombuoside has antioxidant properties, inhibiting ROS production and apoptosis. Ombuoside exerts neuroprotective effects through the ERK-JNK-caspase-3 system. Ombuoside promotes Dopamine biosynthesis through TH and CREB activation. Ombuoside exhibits antimicrobial activity against several Gram-positive and Gram-negative bacteria, as well as Candida albicans

Xanthofulvin SM-216289	Structural Classification Natural Products Microorganisms Source Classification	Drug Derivative
Xanthofulvin (SM-216289) is an inhibitor of semaphorin 3A. Xanthofulvin blocks its binding to receptors, inhibits growth cone collapse, and accelerates olfactory nerve regeneration in rats in vivo. Xanthofulvin can be used in studies related to traumatic neuronal injury .

2-Deoxyecdysone	Structural Classification Natural Products Animals Steroids Source Classification	Endogenous Metabolite
2-Deoxyecdysone is a circulating ecdysteroid found in Z. atratus and functions as a prohormone during the development of some insects .

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