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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
extracellular loop
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "extracellular loop" in MCE Product Catalog:
9
9 Publications Verification
Cat. No.: HY-P1082
CAS No.: 197250-15-0
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9
9 Publications Verification
Cat. No.: HY-P1082A
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8
8 Cited Publications
Cat. No.: HY-P0139
CAS No.: 198284-64-9
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2
2 Cited Publications
Synonyms: LY2940680; ENV-101
Taladegib (LY2940680) is a Smoothened (SMO) antagonist. Taladegib hydrochloride inhibits the Hedgehog signaling pathway, with an IC50 of 5.5 nM for suppressing GLI1 mRNA expression in DAOY cells and an IC50 of 7.6 nM in CGNP cell proliferation assays. Taladegib binds to the extracellular loop region (site 1) of the transmembrane domain of the SMO receptor, competes with cyclopamine for SMO binding, and thereby inhibits Gli-dependent transcription. Taladegib can be used in studies of Hedgehog pathway-related cancers .
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Taladegib (LY2940680) hydrochloride is a Smoothened (SMO) antagonist. Taladegib hydrochloride inhibits the Hedgehog signaling pathway, with an IC50 of 5.5 nM for suppressing GLI1 mRNA expression in DAOY cells and an IC50 of 7.6 nM in CGNP cell proliferation assays. Taladegib hydrochloride binds to the extracellular loop region (site 1) of the transmembrane domain of the SMO receptor, competes with cyclopamine for SMO binding, and thereby inhibits Gli-dependent transcription. Taladegib hydrochloride can be used in studies of Hedgehog pathway-related cancers .
Cat. No.: HY-P1594A
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PDP-Pfp is a reducible ADC Linker used as an active molecule targeting the extracellular loop 1 (ECL1) of TM4SF1 .
Cat. No.: HY-P1594
CAS No.: 79994-24-4
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Cat. No.: HY-129372
CAS No.: 2101206-44-2
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PDdB-Pfp is a cleavable ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) .
Cat. No.: HY-P5389
CAS No.: 403858-30-0
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Cat. No.: HY-P991541
Cat. No.: HY-P10597
CAS No.: 275359-37-0
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Cat. No.: HY-P5387
CAS No.: 514787-21-4
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Cat. No.: HY-118962
CAS No.: 342394-93-8
E913 is a CCR5 antagonist that competes with the binding of antibodies to CCR5 which recognize the C-terminal half of the second extracellular loop (ECL2B) of CCR5. E913 can specifically block the binding of macrophage inflammatory protein-1alpha (MIP-1alpha) to CCR5 (IC50 = 0.002 μM) and MIP-1alpha-elicited cellular Ca 2+ mobilization (IC50 = 0.02 μM). E913 inhibits the replication of laboratory and primary R5 HIV-1 strains as well as various multidrug-resistant monocyte/macrophage tropic (R5) HIV-1 (IC50 = 0.03-0.06 μM). E913 can be used for the research of infection, such as HIV-1 infection .
Cat. No.: HY-P11797
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Cat. No.: HY-P992563
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Anti-Mouse CCR7/CD197 Antibody (C7Mab-2) is a rat-derived IgG2b kappa monoclonal antibody that selectively recognizes mouse CCR7. Anti-Mouse CCR7/CD197 Antibody (C7Mab-2) recognizes the extracellular loop domain of mCCR7 and was prepared by immunization with an extracellular loop peptide. Anti-Mouse CCR7/CD197 Antibody (C7Mab-2) binds with high affinity to cells overexpressing mCCR7, recognizes these cells in flow cytometry, and can be detected in immunohistochemistry of paraffin-embedded cell sections. Anti-Mouse CCR7/CD197 Antibody (C7Mab-2) can be used for CCR7-related assays, such as flow cytometry and immunohistochemistry .
Cat. No.: HY-183050
CAS No.: 3036387-75-1
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HEP-50768 is an orally active and selective MRGPRX4 (hX4) antagonist. HEP-50768 suppresses basal and bile-acid-stimulated hX4 activity. HEP-50768 binds the receptor’s transmembrane pocket and induces extracellular loop rearrangements. HEP-50768 modulates GPCR microswitch motifs and reduces bile-acid-induced pruritic scratching behaviors. HEP-50768 can be used for the research of cholestatic pruritus .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
