551 Results for "

glucosides

" in MedChemExpress (MCE) Product Catalog:

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Geniposide

20 Publications Verification

Cat. No.: HY-N0009

CAS No.: 24512-63-8

Category:

Iridoids Terpenoids Rubiaceae Plants Gardenia jasminoides Ellis

Target:

Amyloid-β Influenza Virus

Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.

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Cynaroside

15 Cited Publications

Cat. No.: HY-N0540

CAS No.: 5373-11-5

Synonyms: Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside

Category:

Flavones Plants Compositae Infection Flavonoids Centaurea ornata Phenols Polyphenols Umbelliferae Disease Research Fields Cirsium vulgare(Savi) Ten.

Target:

Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal

Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

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Aucubin

11 Cited Publications

Cat. No.: HY-N0664

CAS No.: 479-98-1

Category:

Infection Eucommia ulmoides Oliver Neurological Disease Iridoids Terpenoids Eucommiaceae Plants Disease Research Fields Inflammation/Immunology

Target:

Bacterial

Aucubin is an iridoid glycoside component that acn be found in E. ulmoides. Aucubin can cross the blood-brain barrier (BBB) and has anti-anxiety, antidepressive and anti-neuroinflammatory effects. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .

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Isoquercitrin

9 Cited Publications

Cat. No.: HY-N1445

CAS No.: 482-35-9

Synonyms: Isoquercetin; Quercetin 3-glucoside

Category:

Apocynaceae Flavonols Flavonoids Phenols Polyphenols Plants Apocynum venetum Linn. Disease Research Fields Cancer

Target:

NF-κB NO Synthase

Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway . Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies .

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Apigenin 7-glucoside

8 Cited Publications

Cat. No.: HY-N0578

CAS No.: 578-74-5

Synonyms: Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigetrin

Category:

Flavonoids Flavones Dendranthema morifolium (Ramat.) Tzvel. Phenols Polyphenols Plants Compositae Disease Research Fields Cancer

Target:

Reactive Oxygen Species (ROS)

Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS) .

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Amygdalin

8 Cited Publications

Cat. No.: HY-N0190

CAS No.: 29883-15-6

Category:

Alkaloids Other Alkaloids Rosaceae Armeniaca vulgaris Lam. Plants Disease Research Fields Cancer

Target:

Others

Amygdalin is a plant glucoside isolated from the stones of rosaceous fruits, such as apricots, peaches, almond, cherries, and plums.

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Glycitin

8 Cited Publications

Cat. No.: HY-N0012

CAS No.: 40246-10-4

Synonyms: Glycitein 7-O-β-glucoside

Category:

Infection Flavonoids Monophenols Leguminosae Glycine max (L.) merr Phenols Plants Disease Research Fields Isoflavones

Target:

Bacterial

Glycitin (Glycitein 7-O-β-glucoside) is a natural isoflavone with antibacterial, antiviral, anticancer, anti-inflammation, anti-aging and estrogenic effects. Glycitin may regulate osteoblasts through TGF-β or AKT signaling pathways in bone marrow stem cells (BMSCs) .

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Parishin

5 Cited Publications

Cat. No.: HY-N2031

CAS No.: 62499-28-9

Category:

Other Terpenoids Gastrodia elata Bl. Orchidaceae Terpenoids Plants

Target:

Others

Parishin is a phenolic glucoside isolated from Gastrodia elata. Parishin exhibits antiaging effects and extends the lifespan of yeast via regulation of Sir2/Uth1/TOR signaling pathway .

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Isorhamnetin-3-O-glucoside

5 Cited Publications

Cat. No.: HY-N0777

CAS No.: 5041-82-7

Category:

Cruciferous vegetables Flavonols Flavonoids Metabolic Disease Phenols Polyphenols Plants Brassicaceae Disease Research Fields

Target:

Others PERK ERK Akt PI3K Lipase

Isorhamnetin-3-O-glucoside is an orally active natural compound. Isorhamnetin 3-O-glucoside increases P-ERK, ERK, P-Akt (Ser473), P-PI3K, and PDX-1. Isorhamnetin 3-O-glucoside downregulates C/EBPα and inhibits lipase. Isorhamnetin 3-O-glucoside reduces lipids and inhibits obesity .

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Calycosin-7-O-β-D-glucoside

5 Cited Publications

Cat. No.: HY-N0520

CAS No.: 20633-67-4

Synonyms: Calycosin-7-glucoside

Category:

Flavonoids Monophenols Leguminosae Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Phenols Plants Disease Research Fields Isoflavones

Target:

Reactive Oxygen Species (ROS)

Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects .

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6''-O-Acetylglycitin

5 Cited Publications

Cat. No.: HY-N4072

CAS No.: 134859-96-4

Category:

Flavonoids Monophenols Leguminosae Glycine max (L.) merr Metabolic Disease Phenols Plants Disease Research Fields Isoflavones

Target:

Others

6''-O-Acetylglycitin, a acetyl glucoside, is one of the isoflavone isomer in soybeans, shows various extents of content reduction dependent on storage temperature, packaging condition, and its isoflavone isomer kind .

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Fraxin

5 Cited Publications

Cat. No.: HY-N0579

CAS No.: 524-30-1

Synonyms: Fraxoside

Category:

Oleaceae Fraxinus rhynchophylla Hance Coumarins Plants other families Monophenols Phenols Phenylpropanoids Disease Research Fields Inflammation/Immunology

Target:

Phosphodiesterase (PDE)

Fraxin isolated from Cortex Fraxini, is a glucoside of fraxetin and reported to exert potent anti-oxidative stress action , anti-inflammatory and antimetastatic properties. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme .

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Esculin sesquihydrate

5 Cited Publications

Cat. No.: HY-W166297

CAS No.: 66778-17-4

Target:

p38 MAPK

Research Areas:

Cancer

Esculin sesquihydrate, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin sesquihydrate ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the MAPK signaling pathway .

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Esculin

5 Cited Publications

Cat. No.: HY-N0188

CAS No.: 531-75-9

Category:

other families Monophenols Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Cancer

Target:

p38 MAPK

Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

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Meloside A

5 Cited Publications

Cat. No.: HY-N5124

CAS No.: 60767-80-8

Synonyms: Isovitexin 2''-O-glucoside; Isovitexin 2''-O-β-D-glucoside

Category:

Infection Flavonoids Flavones Phenols Polyphenols Plants Actaea dahurica Turcz. ex Fisch. & C. A. Mey. Rhamnaceae Disease Research Fields

Target:

Androgen Receptor Apoptosis Reactive Oxygen Species (ROS) Interleukin Related TGF-β Receptor

Meloside A (Isovitexin 2''-O-glucoside) is a flavonoid with antioxidant activity. Meloside A can inhibit cell apoptosis and ROS production. Meloside A can inhibit androgen receptor (AR) nuclear translocation and AR protein expression. Meloside A can reduce IL-6, TGF-β1 and DKK-1 levels. Meloside A can be used for the researches of inflammation and endocrinology, such as hair loss .

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Isomangiferin

4 Cited Publications

Cat. No.: HY-N0772

CAS No.: 24699-16-9

Category:

Infection Liliaceae Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields

Target:

VEGFR NOD-like Receptor (NLR) NF-κB Bacterial AMPK Acetyl-CoA Carboxylase Apoptosis Reactive Oxygen Species (ROS) HSV Drug Derivative

Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing .

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2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside

3 Cited Publications

Cat. No.: HY-N0652

CAS No.: 82373-94-2

Synonyms: 2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside

Category:

Stilbenes Polygonaceae Other Diseases Phenols Polyphenols Fallopia multiflora (Thunb.) Harald. Plants Disease Research Fields

Target:

ERK NF-κB

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside isolats from the roots of Polygonaceae species, inhibits the formation of 5-HETE, HHT and thromboxane B2. 2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside has hypotensive, anti-ageing, anti-inflammatory, hypolipidemic, cardioprotective, and neuroprotective actions .

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Emodin-8-glucoside

2 Cited Publications

Cat. No.: HY-N0311

CAS No.: 23313-21-5

Category:

Quinones other families Anthraquinones Phenols Polyphenols Plants Disease Research Fields Cancer

Target:

Aldose Reductase Topoisomerase SOD p38 MAPK

Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC₅₀s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier .

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Shanziside

2 Cited Publications

Cat. No.: HY-N4092

CAS No.: 29836-27-9

Category:

Iridoids Labiatae Terpenoids Phaseolus lunatus L. Other Diseases Plants Disease Research Fields

Target:

Others

Shanziside is a iridoid glucoside isolated from Phlomis tuberosa L .

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Methylnissolin-3-O-glucoside

2 Cited Publications

Cat. No.: HY-N2473

CAS No.: 94367-42-7

Category:

Flavonoids Leguminosae Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Inflammation/Immunology Other Flavonoids

Target:

Drug Derivative Akt Keap1-Nrf2 Heme Oxygenase (HO) Quinone Reductase MEK ERK Free Radical Scavengers

Methylnissolin-3-O-glucoside is a flavonoid glycoside derivative of Methylnissolin (HY-N2484). Methylnissolin-3-O-glucoside is isolated from plants of the genus Astragalus (Leguminosae). Methylnissolin-3-O-glucoside effectively induces the expression of AKT/Nrf2 and its downstream target genes HO-1 and NQO1. Methylnissolin-3-O-glucoside inhibits TNF-α-induced phosphorylation of MEK and ERK . Methylnissolin-3-O-glucoside exhibits free radical scavenging activity. Methylnissolin-3-O-glucoside inhibits cell proliferation and cell migration. Methylnissolin-3-O-glucoside is used in research on esophageal squamous cell carcinoma .

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