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influenza viruses

" in MedChemExpress (MCE) Product Catalog:

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研究分野別:	Cancer (76) Cardiovascular Disease (7) Endocrinology (8) Infection (406) Inflammation/Immunology (76) Metabolic Disease (10) Neurological Disease (31)
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446

阻害剤およびアゴニスト

スクリーニングライブラリ

蛍光色素

生化学アッセイ試薬

ペプチド

阻害性抗体

天然物

同位体標識化合物

クリックケミストリー

オリゴヌクレオチド

Targets Recommended: Influenza Virus

製品番号	製品名	Target	研究分野	構造式

HY-W019823

4-MUNANA 2 Publications Verification	Fluorescent Dye	Infection Neurological Disease
4-MUNANA is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses .

HY-13317

Oseltamivir 45+ Cited Publications GS 4104	Influenza Virus	Infection Cancer
Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively .

HY-135853

Molnupiravir 70+ Cited Publications EIDD-2801; MK-4482	SARS-CoV Influenza Virus	Infection
Molnupiravir (EIDD-2801) is an orally bioavailable proagent of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against **influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV*. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza* .

HY-138941

Octaethylene glycol monododecyl ether 1 Publications Verification C12E8	Influenza Virus	Infection
Octaethylene glycol monododecyl ether (C12E8) is an non-ionic detergent that can be used for membrane protein extraction. Octaethylene glycol monododecyl ether can solubilize the viral membrane of intact **influenza virus** .

HY-N0035

Arctigenin 10+ Cited Publications (-)-Arctigenin	MMP Influenza Virus Autophagy Apoptosis	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .

HY-145586

Onradivir ZSP1273	Influenza Virus DNA/RNA Synthesis	Infection
Onradivir (ZSP1273) is an orally active antiviral agent targeting influenza A virus RNA polymerase PB2 subunit with an IC₅₀ of 0.562 nM. Onradivir inhibits cap binding to influenza A virus RNA polymerase PB2 subunit, suppresses viral replication, reduces viral titres and RNA loads, and inhibits influenza A virus infection. Onradivir maintains high survival rates in influenza A virus-infected mice, and reduces influenza A virus titers in a murine model. Onradivir can be used for the research of influenza A virus infection .

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis	Infection Neurological Disease
Urolithin M5 (Decarboxyellagic acid) is an orally active **influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀** values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .

HY-P99750

Navivumab CT-P23	Influenza Virus	Infection
Navivumab (CT-P23) is a monoclonal antibody targeting the hemagglutinin (HA) of **influenza A virus*. Navivumab binds to the HA2 stem fusion domain and the low-variability HA2 region of influenza* viruses. Navivumab neutralizes influenza A viruses of subtypes H1, H2, H5, and H9. Navivumab is applicable to research related to influenza and influenza A .

HY-P991446

MEDI-8852	Influenza Virus	Infection
MEDI-8852 is a human IgG1 monoclonal antibody against influenza A virus hemagglutinin (HA). MEDI-8852 binds to the conserved HA stalk epitope and neutralizes viral infectivity. MEDI-8852 reduces viral titers in mouse lung tissues. MEDI-8852 is applicable to research related to pandemic influenza . Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-139558

Zapnometinib PD0184264; ATR-002	MEK Influenza Virus Bacterial	Infection Cancer
Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC₅₀ of 5.7 nM. Zapnometinib exhibits antiviral activity against influenza virus and antibacterial activities .

HY-W011518

2′-Deoxy-2′-fluoroguanosine 1 Publications Verification	Nucleoside Antimetabolite/Analog Influenza Virus	Infection
2′-Deoxy-2′-fluoroguanosine is a nucleoside analog and potent **influenza virus inhibitor with an EC₉₀** value of <0.35 μM against influenza A and B viruses. 2′-Deoxy-2′-fluoroguanosine inhibits influenza virus replication in the upper respiratory tract, thereby ameliorating fever and nasal inflammation .

HY-14837

Amizon Enisamium iodide	Influenza Virus SARS-CoV	Infection
Amizon is an orally effective antiviral and anti-inflammatory agent. Amizon inhibits **influenza virus replication and restricts viral RNA synthesis. Amizon reduces the mRNA expression of COX-1, COX-2, NF-κB, TGF1β, IL-1 and IL-6*, and stimulates the secretion and mRNA expression of IL-10. Amizon inhibits the oxidative activity of macrophages and possesses antioxidant and free radical-scavenging activities. Amizon is applicable to research related to influenza* and acute respiratory viral infections .

HY-N11630

Pinellic acid	Influenza Virus Biochemical Assay Reagents	Infection
Pinellic acid is an orally active adjuvant for intranasal influenza vaccines. Pinellic acid can be extracted from the tubers of Pinellia ternata Breitenbach. When administered intranasally in combination with influenza HA vaccine, Pinellic acid slightly increases the titers of antiviral IgG antibodies in bronchoalveolar lavage fluid and serum. Pinellic acid shows no hemolytic activity. Pinellic acid can be used in studies related to influenza virus infection .

HY-158312

UH15-38 1 Publications Verification	Necroptosis RIP kinase Influenza Virus	Infection Inflammation/Immunology
UH15-38 is a potent RIPK3 inhibitor with an IC₅₀ value of 20 nM. UH15-38 blocks IAV (influenza A virus)-activated necroptosis. UH15-38 dampens IAV-induced lung injury .

HY-P991059

VIS-410	Influenza Virus	Infection
VIS-410 is an antibody inhibitor targeting the stem region of hemagglutinin (HA). VIS-410 inhibits **influenza virus** replication by blocking HA-mediated membrane fusion. VIS-410 exhibits broad-spectrum neutralization against influenza A viruses with group 1 and group 2 hemagglutinins, including subtypes such as H1N1, H3N2, H5N1, and H7N9 (H5N1 IC₅₀ = 1.5 μg/mL). VIS-410 is applicable to research related to influenza A virus infection .

HY-DY1034

4-MUNANA (solution)	Fluorescent Dye	Infection Neurological Disease
4-MUNANA (solution) is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses . Solvent and Concentration: Sterile water: 10 mM

HY-W012738

DL-Pyroglutamic acid 1 Publications Verification	Influenza Virus GABA Receptor	Infection
DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action .

HY-156048

Trifluoromethyl-tubercidin 2 Publications Verification TFMT	Influenza Virus	Infection
Trifluoromethyl-tubercidin (TFMT) is an inhibitor of 2'-O-ribose methyltransferase 1 (MTr1). Trifluoromethyl-tubercidin can inhibit the replication of influenza A and B viruses by interfering with the cap-snatching process of the influenza virus. Trifluoromethyl-tubercidin has antiviral activity and low toxicity .

HY-164390

6′SLN Neu5Acα2-6Galβ1-4GlcNAc	Endogenous Metabolite	Infection Cancer
6′SLN is a cancer-related extracellular vesicle (EVs) surface glycan that serves as a key form of protein glycosylation in EVs. 6′SLN is also a sialic acid derivative that can interact with hemagglutinins (HAs) from human and avian influenza virus strains, making it useful for research into anti-influenza drugs .

HY-D0871

CHES N-Cyclohexyltaurine	Biochemical Assay Reagents Influenza Virus	Infection
CHES (N-Cyclohexyltaurine) is a biological buffer reagent that binds to influenza virus hemagglutinin (HA). CHES mimics the binding mode of sialic acid to the HA receptor-binding site .

HY-177555

AV5116	Influenza Virus Endonuclease	Infection
AV5116 is a cap-dependent endonuclease inhibitor (CENI) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic. AV5116 exhibits potent inhibitory activity against influenza viruses (influenza A, B, and C viruses). AV5116 can be used for the study of **influenza virus** infections .

HY-P990811

*Anti-Influenza* A virus NP Antibody (H16-L10-4R5 (HB-65))**	Influenza Virus	Infection
Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) is mouse-derived IgG2a κ type antibody inhibitor, targeting to influenza virus nucleoprotein. Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) reacts with influenza virus nucleoprotein (NP). Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) can induce passive immunity to influenza A virus. Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) can be used for the detections of western blot, flow cytometry and immunohistochemistry in Influenza A virus infection .

HY-P1837

Influenza HA (518-526)	Influenza Virus HSV	Infection
Influenza HA (518-526) is an H-2d-restricted CTL epitope derived from influenza virus hemagglutinin. Influenza HA (518-526) is highly conserved across various H5N1, some H9N2, and H1N1 strains. Influenza HA (518-526) binds to the mouse MHC class I allele K ^d to form a complex, which is then recognized by specific CD8 ⁺ T cells. Influenza HA (518-526) is an immunodominant epitope in influenza-infected BALB/c mice, and it stimulates CD8 ⁺ T cells to secrete IFN-γ to induce a robust immune response. Currently, Influenza HA (518-526) is widely used in research related to respiratory syncytial virus (RSV), **influenza virus, and H5N1** influenza .

HY-137334

Neuraminidase-IN-1	Influenza Virus	Infection
Neuraminidase-IN-1 is a neuraminidase inhibitor, with an IC₅₀ of 0.21 μM. Neuraminidase-IN-1 has excellent activity against H1N1 influenza virus .

HY-13317R

Oseltamivir (Standard) GS 4104 (Standard)	Reference Standards Influenza Virus	Infection
Oseltamivir (Standard) is the analytical standard of Oseltamivir. This product is intended for research and analytical applications. Oseltamivir (GS 4104) is an orally active influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively .

HY-131069A

MBX2329	Influenza Virus	Infection
MBX2329, a potent **influenza virus** inhibitor, specifically inhibits hemagglutinin (HA)-mediated viral entry with HIV/HA(H5) displaying IC₉₀ of 8.6 μM. MBX2329 inhibits a wide spectrum of influenza A viruses, which includes the 2009 pandemic influenza virus A/H1N1/2009, highly pathogenic avian influenza (HPAI) virus A/H5N1, and oseltamivir-resistant A/H1N1 strains .

HY-W892911

AV-5080	Influenza Virus	Infection
AV-5080 is an orally active neuraminidase inhibitor. AV-5080 can be used for the research of influenza A and B viruses .

HY-123304

MBX2546	Influenza Virus	Infection
MBX2546 is a **influenza A virus inhibitor with the K_d** values of 5.3μM and ＞ 100 μM for H1 Hemagglutinin and H3 Hemagglutinin, respectively .

HY-N10581

Flutimide	Influenza Virus	Infection
Flutimide is a novel endonuclease inhibitor of influenza virus. Flutimide selectively inhibits endonuclease with an IC₅₀ value of 3 μM. Flutimide shows antiviral activity in cell culture. Flutimide can be used for the research of acute contagious respiratory disease, such as influenza .

HY-N7346

Lucidadiol	HSV Cholinesterase (ChE)	Infection
Lucidadiol is a natural compound isolated from Ganoderma lucidum. Lucidadiol exhibits acetylcholinesterase-inhibitory activity, with IC₅₀ values of 31 μM. Lucidadiol shows antiviral activity against influenza virus type A and HSV type 1 .

HY-112543

S119-8	Influenza Virus	Infection
S119-8 is a broad spectrum inhibitor of influenza A and B viruses, showing activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV) .

HY-172515

ent-Oseltamivir	Influenza Virus Virus Protease Drug Isomer	Infection
ent-Oseltamivir, the enantiomer of Oseltamivir (HY-13317), is a neuraminidase (NA) of influenza virus inhibitor. ent-Oseltamivir is promising for research of influenza virus infections .

HY-145586A

Onradivir monohydrate ZSP1273 monohydrate	Influenza Virus DNA/RNA Synthesis	Infection
Onradivir (ZSP1273) monohydrate is an orally active antiviral agent targeting influenza A virus RNA polymerase PB2 subunit with an IC₅₀ of 0.562 nM. Onradivir monohydrate inhibits cap binding to influenza A virus RNA polymerase PB2 subunit, suppresses viral replication, reduces viral titres and RNA loads, and inhibits influenza A virus infection. Onradivir monohydrate maintains high survival rates in influenza A virus-infected mice, and reduces influenza A virus titers in a murine model. Onradivir monohydrate can be used for the research of influenza A virus infection .

HY-129150

Ganoderic acid TR	Influenza Virus	Infection
Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs). Ganoderic acid TR has IC₅₀ values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317)-resistant H1N1 viruses and influenza B viruses .

HY-143769

Sebaloxavir marboxil Cap-dependent endonuclease-IN-15	Influenza Virus	Infection
Sebaloxavir marboxil (Cap-dependent endonuclease-IN-15) (Compound c-1) is a potent inhibitor of cap-dependent endonuclease (CEN). Sebaloxavir marboxil inhibits the replication of influenza virus. Sebaloxavir marboxil has the potential for the research of viral infections caused by influenza viruses .

HY-145391

Triperiden	Influenza Virus	Infection
Triperiden is an inhibitor of influenza virus multiplication. Triperiden targets the haemagglutinin of fowl plague virus (FPV) for antiviral activity and acts by inhibiting the conformational change in the haemagglutinin at acid pH. Triperiden is also anticholinergic anti-parkinsonism agent .

HY-177791

vRNPs degrader-1	PROTACs Influenza Virus	Infection
vRNPs degrader-1 is a potent PROTAC viral ribonucleoproteins (vRNPs) degrader. vRNPs degrader-1 shows broad-spectrum anti-influenza A viruses (IAV) activity by targeting the conserved 5′ end of viral RNA, thereby inducing proteasomal degradation of viral proteins. vRNPs degrader-1 inhibits H1N1, H9N2, and H3N2 infection in mice. vRNPs degrader-1 can be used for influenza research .

HY-P1937

Cyclo(-Met-Pro)	Influenza Virus	Infection
Cyclo(-Met-Pro) is a cyclic dipeptide consisting of the amino acids methionine and proline. Cyclo(-Met-Pro) exhibits weak inhibitory activity against the influenza A virus (H3N2) (5 mM, 2.1% inhibition), while cis-cyclo(Leu-Pro) and cis-cyclo(Phe-Pro) shows significant antiviral activity .

HY-147974

HSP90-IN-14	HSP Influenza Virus	Infection
HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a K_d of 0.26 μM. HSP90-IN-14 shows *anti-influenza* virus activity in MDCK cells, with EC₅₀ values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively .

HY-P991054

CR-8020	Influenza Virus	Infection
CR-8020 is a human IgG1 antibody that targets influenza A virus H3N2. CR-8020 binds to hemagglutinin (HA) of H3N2 strains with IC₅₀s of 3.36 nM and 0.06 nM for A/Brisbane/10/2007 and A/Wyoming/3/2003, respectively. The isotype control for CR-8020 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-N0035R

Arctigenin (Standard) (-)-Arctigenin (Standard)	Reference Standards MMP Influenza Virus Autophagy Apoptosis	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Arctigenin (Standard) is the analytical standard of Arctigenin. This product is intended for research and analytical applications. Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .

HY-155476

Influenza virus-IN-8	Influenza Virus	Infection
Influenza virus-IN-8 (compound A4) is an inhibitor of influenza virus (Influenza Virus) that induces viral nucleoprotein (NP) aggregation and prevents its nuclear accumulation. Influenza virus-IN-8 has broad-spectrum anti-influenza activity and can inhibit the replication and transcription of influenza A virus. Influenza virus-IN-8 also inhibits Oseltamivir (HY-13317)-resistant H1N1/pdm09 strains .

HY-146004

Influenza A virus-IN-4	Influenza Virus	Infection
Influenza A virus-IN-4 (compound 23b), an Oseltamivir derivative, is a potent inhibitor of neuraminidase. Influenza A virus-IN-4 exerts powerful inhibitions on influenza viruses .

HY-146147

Influenza virus-IN-5	Influenza Virus	Infection
Influenza virus-IN-5 (Compound 5f) is an inhibitor of influenza virus hemagglutinin (HA) with an EC₅₀ of 1 nM against influenza A/H3N2 virus .

HY-156288

Anti-Influenza agent 5	Influenza Virus	Infection
Anti-Influenza agent 5 (Compound IIB-2), chalcone-like derivative, is an influenza nuclear export inhibitor. Anti-Influenza agent 5 has inhibitory effects on oseltamivir-resistant strains. Anti-Influenza agent 5 can impede virus proliferation by blocking the export of influenza virus nucleoprotein .

HY-170646

Influenza A virus-IN-15	Influenza Virus	Infection
Influenza A virus-IN-15 (Compound 9b), a quinoline derivative, is a broad-spectrum inhibitor of influenza A viruses with acceptable cytotoxicity (IC₅₀: 0.88-6.33 μM). Influenza A virus-IN-15 can inhibit the transcription and replication of viral RNA and is used in research for its antiviral effects against influenza A viruses (IAV) .

HY-152239

RdRP-IN-5	DNA/RNA Synthesis Influenza Virus	Infection
RdRP-IN-5 (compound 20) is a potent influenza virus RNA-dependent RNA polymerase (RdRP) inhibitor. RdRP-IN-5 can be used in research of influenza virus .

HY-152239B

trans-RdRP-IN-11	DNA/RNA Synthesis Influenza Virus	Infection
trans-RdRP-IN-5 (compound 18) is a potent influenza virus RNA-dependent RNA polymerase (RdRP) inhibitor. trans-RdRP-IN-5 can be used in research of influenza virus .

HY-152239A

cis-RdRP-IN-11	DNA/RNA Synthesis Influenza Virus	Infection
cis-RdRP-IN-5 (compound 19) is a potent influenza virus RNA-dependent RNA polymerase (RdRP) inhibitor. cis-RdRP-IN-5 can be used in research of influenza virus .

HY-119213

BMY-27709	Influenza Virus	Infection
BMY-27709 is an influenza virus growth inhibitor with an IC₅₀ value of 3-8 μM against A/WSN/33 virus growth, and also exhibits inhibitory activity against some subtypes of influenza viruses. BMY-27709 acts early in the course of H1 and H2 virus infections, and exhibits antiviral activity through inhibition of hemagglutinin proteins. However, BMY-27709 has no effect on H3 subtype viruses and influenza B/Lee/40 viruses .

製品番号	製品名

HY-L027

Antiviral Compound Library

1,180 compounds

Viruses are much simpler organisms than bacteria, and they are made from protein substances and nucleic acid. Despite the fact that the exact mechanism of infection is extremely specific to each type of virus, the general scheme of infection can be represented in the following manner: A virus is absorbed at the surface of a host cell and then permeates through the membrane, where it releases nucleic acid from its protein protection. Then the viral nucleic acid begins to replicate, and transcription of the viral genome takes place either in the cytoplasm, or in the nucleus of the host cell. As a result of these events, a large amount of viral nucleic acid and protein are made to make new generations of virions. Therefore, one mechanism of action of antiviral drugs is to interfere with the ability of a virus to get into a target cell. A second mechanism of action is to target the processes that synthesize virus components after a virus invades a cell, such as nucleotide or nucleoside analogs.

MCE designs a unique collection of 1,180 anti-virus compounds that target several viruses, including SARS-CoV, HBV, HCV, HIV, HSV and Influenza Virus. It’s an effective tool for anti-virus drug discovery.

HY-L113

Antiviral Traditional Chinese Medicine Active Compound Library

235 compounds

Increasing research have shown that Traditional Chinese Medicine (TCM) possess antiviral activities against various viral strains, such as herpes simplex virus, influenza virus, hepatitis B and C viruses, and SARS-CoV. To date, dozens of Chinese herbs and hundreds of natural TCM ingredients have been reported to exhibit good antiviral activities. Active components from TCM are one of the important sources for antiviral drugs discovery.

MCE designs a unique collection of 235 active compounds of antiviral Chinese Herbal Medicines. MCE Antiviral Traditional Chinese Medicine Active Compound Library is a useful tool for discovery antiviral drugs from TCM.

HY-L940

Antiviral Lead-like compound library

5,813 compounds

Owing to the widespread transmission and frequent mutation of viral diseases, as well as the continuous emergence of new viruses and drug-resistant strains, antiviral drug development is facing increasingly stringent requirements. Antiviral compound libraries serve as important tools for drug screening, mechanism research and development, enabling the discovery and investigation of various antiviral drugs.

These compounds act through diverse antiviral mechanisms, targeting key steps in viral replication, assembly and invasion. They exert antiviral effects by inhibiting viral nucleic acid synthesis, blocking viral protein processing, and preventing viral binding to host cells. This library covers various types of antiviral compounds, including nucleosides, non-nucleosides, protease inhibitors and integrase inhibitors. It supports research on influenza virus, herpes virus, hepatitis virus, emerging respiratory viruses and other pathogens, and enables high-throughput screening of novel antiviral candidates to rapidly identify potential active compounds against diverse viruses. It also facilitates mechanistic studies to elucidate drug-target interactions and viral resistance mechanisms, and supports the screening of effective compounds against mutant strains for research on viral variation and drug resistance.

This antiviral library consists of 6,804 compounds with lead-like physicochemical properties. The core sources of the compounds include analogs of known antiviral molecues with a similarity score ≥ 0.6. MCE has collected more than 1450 antiviral molecules. As a small-molecule collection with both activity potential and structural modifiability, it provides strong support for antiviral drug research and development.

HY-L002

Anti-Infection Compound Library

4,310 compounds

An infection occurs when another organism enters a person’s body and causes disease. The organisms that cause infections are very diverse and can include things like viruses, bacteria, fungi, and parasites. The immune system is an effective barrier against infectious agents.

MCE provides a unique collection of 4,310 anti-infective compounds with anti-bacterial, anti-viral, anti-fungal and anti-parasite activities that can be used for drug screening and other research in anti-microbial area.

製品番号	製品名	Type

HY-W019823

4-MUNANA

2 Publications Verification

蛍光色素

4-MUNANA is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses .

HY-DY1034

4-MUNANA (solution)

蛍光色素

4-MUNANA (solution) is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. 4-MUNANA can be used in influenza-related research, such as screening NA inhibitors, developing new anti-influenza drugs, and studying the infection mechanism of influenza viruses .
Solvent and Concentration: Sterile water: 10 mM

HY-D0871

CHES N-Cyclohexyltaurine	蛍光色素
CHES (N-Cyclohexyltaurine) is a biological buffer reagent that binds to influenza virus hemagglutinin (HA). CHES mimics the binding mode of sialic acid to the HA receptor-binding site .

HY-D2982

BTP9-Neu5Ac	蛍光色素
BTP9-Neu5Ac is a fluorescent imaging probe specifically designed for detecting the neuraminidase (NA) sialidase activity of influenza viruses. BTP9-Neu5Ac can visualize the intracellular Golgi localization of the viral NA activity. BTP9-Neu5Ac can be used for precise and temporal monitoring of the key enzyme activities during the viral life cycle .

製品番号	製品名	Type

HY-Y1883

Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant

20+ Cited Publications

生化学アッセイ試薬

Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is a non-denaturing detergent that solubilizes lipid membranes. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is listed as an excipient in certain vaccines including split virus influenza vaccines. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant is a nonionic surfactant. Polyethylene glycol mono(4-tert-octylphenyl) ether surfactant induces Apoptosis in prostate and colon cancer cell lines and reduces the infectivity of classic enveloped viruses such as WNV .

HY-119575

Tetramethyluric acid 1,3,7,9-Tetramethyluric acid; Theacrine	生化学アッセイ試薬
Tetramethyluric acid (1,3,7,9-Tetramethyluric acid) is an orally active purine alkaloid in Coffea species and Camellia kucha. Tetramethyluric acid exhibits antiviral, and anti-inflammatory activity. Tetramethyluric acid can be used for the research of inflammation disease, and influenza virus infection .

HY-D0871

CHES N-Cyclohexyltaurine	生化学アッセイ試薬
CHES (N-Cyclohexyltaurine) is a biological buffer reagent that binds to influenza virus hemagglutinin (HA). CHES mimics the binding mode of sialic acid to the HA receptor-binding site .

HY-133172

Zanamivir amine	生化学アッセイ試薬
Zanamivir amine is a neuraminidase inhibitor with antiviral activity. Zanamivir amine can effectively inhibit the proliferation of influenza virus. Zanamivir amine is clinically used to inhibit influenza infection. Zanamivir amine reduces viral load by interfering with the viral replication process.

製品番号	製品名	Target	研究分野

HY-P1939

Cyclo(L-Leu-L-Pro) Cyclo(L-prolyl-L-leucyl)	Fungal Bacterial Influenza Virus	Infection
Cyclo(L-Leu-L-Pro) is a cyclic dipeptide with broad-spectrum antibacterial, antiviral and antifungal activities. Its biological activity is highly dependent on the stereoconfiguration and is widely present in microbial metabolites. Cyclo(L-Leu-L-Pro) efficiently and specifically inhibits the production of aflatoxin by Aspergillus flavus. The cis configuration of Cyclo(L-Leu-L-Pro) (cis-cyclo(L-Leu-L-Pro)) has broad-spectrum antibacterial activity against multi-drug resistant bacteria and significantly inhibits the influenza A virus H3N2 .

HY-P2310

Defensin HNP-1 human	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-P1934

Cyclo(Phe-Pro) 5+ Cited Publications Cyclo(phenylalanylprolyl); A-64863	HCV Bacterial Antibiotic Reactive Oxygen Species (ROS)	Infection
Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .

HY-P2310A

Defensin HNP-1 human TFA	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor Interleukin Related NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human TFA is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human TFA possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human TFA inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human TFA has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human TFA has antileishmanial activity. Defensin HNP-1 human TFA is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-P3823

Asp-Asp-Asp-Asp-Asp-Asp	Influenza Virus	Infection
Asp-Asp-Asp-Asp-Asp-Asp is a polyaspartic acid. The specificity of the catalytic and antigenic sites of influenza virus neuraminidase is related to the number of specific amino acids.

HY-P10056

HEP-1 Human ezrin peptide (324-337)	HIV HCV HPV Influenza Virus Interleukin Related	Infection Inflammation/Immunology
HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and **influenza viruses**. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases .

HY-P1837

Influenza HA (518-526)	Influenza Virus HSV	Infection
Influenza HA (518-526) is an H-2d-restricted CTL epitope derived from influenza virus hemagglutinin. Influenza HA (518-526) is highly conserved across various H5N1, some H9N2, and H1N1 strains. Influenza HA (518-526) binds to the mouse MHC class I allele K ^d to form a complex, which is then recognized by specific CD8 ⁺ T cells. Influenza HA (518-526) is an immunodominant epitope in influenza-infected BALB/c mice, and it stimulates CD8 ⁺ T cells to secrete IFN-γ to induce a robust immune response. Currently, Influenza HA (518-526) is widely used in research related to respiratory syncytial virus (RSV), **influenza virus, and H5N1** influenza .

HY-P1749

Influenza HA (307-319)	Influenza Virus	Infection
Influenza HA (307-319) is 13 amino acids 307 to 319 fragment of Influenza HA. Influenza HA is a glycoprotein found on the surface of influenza viruses .

HY-P1937

Cyclo(-Met-Pro)	Influenza Virus	Infection
Cyclo(-Met-Pro) is a cyclic dipeptide consisting of the amino acids methionine and proline. Cyclo(-Met-Pro) exhibits weak inhibitory activity against the influenza A virus (H3N2) (5 mM, 2.1% inhibition), while cis-cyclo(Leu-Pro) and cis-cyclo(Phe-Pro) shows significant antiviral activity .

HY-P5550

Urumin	Influenza Virus	Infection
Urumin has antiviral activity against the human influenza A virus. Urumin inhibits the growth of PR8 influenza virus (IC₅₀: 3.8 μM). Urumin targets the conserved stalk of H1 hemagglutini, and is effective at neutralizing drug-resistant H1 influenza viruses. Urumin protects naive mice from lethal influenza infection .

HY-P0289

CEF3	Influenza Virus	Infection
CEF3 (SIIPSGPLK) corresponds to aa 13-21 of the influenza A virus M1 protein. The matrix (M1) protein of influenza A virus is a multifunctional protein that plays essential structural and functional roles in the virus life cycle.

HY-P2520

Influenza HA (110-119)	Influenza Virus	Inflammation/Immunology
Influenza HA (110-119) is the 110-119 fragment of influenza virus hemagglutinin that can stimulate Treg cells proliferation .

HY-P5502

Influenza NP (311-325)	Influenza Virus	Others
Influenza NP (311-325) is a biologically active peptide derived from the influenza virus nucleoprotein (NP). The NP protein is an MHC class II restricted epitope that elicits host immune responses during viral infection. Influenza NP (311-325) elicits the most potent interferon gamma (IFN-γ) production without stimulating CD8 T cells in mice.

HY-P3747

Hemagglutinin (48-68)	Influenza Virus	Infection
Hemagglutinin (48-68) is the 48-68 fragment of influenza virus hemagglutinin. Hemagglutinin (48-68) can induce proliferation of the peptide specific T-cell clones .

HY-P5642

Retrocyclin-101 RC-101	Bacterial Ser/Thr Protease Influenza Virus HSV SARS-CoV Toll-like Receptor (TLR) Fungal HIV Flavivirus	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression .

HY-P5644

Retrocyclin-3	Bacterial	Infection
Retrocyclin-3 is an antimicrobial peptide against human immunodeficiency virus, influenza A and herpes simplex virus .

HY-P5643

Retrocyclin-2	Bacterial	Infection
Retrocyclin-2 is an antimicrobial peptide against human immunodeficiency virus, influenza A and herpes simplex virus .

HY-149034

Influenza A virus-IN-8 S5	Influenza Virus	Infection Cancer
Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC₅₀s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a K_d of 1.0 nM .

HY-P2561

Influenza Matrix Protein (61-72)	Influenza Virus	Infection Inflammation/Immunology
Influenza Matrix Protein (61-72) is a peptide fragment derived from matrix protein of influenza viruses, corresponds to amino acids 61-72. Influenza Matrix Protein (61-72) is a specific epitope which can induce CD4 ⁺ T-cell response .

HY-P5947

Tat-HA-NR2B9c	HIV	Neurological Disease
Tat-HA-NR2B9 contains a fragment of the cellmembrane transduction domain of HIV-1 Tat, a influenza virus hemagglutinin (HA) epitope-tag, and the C-terminal 9 amino acids of NR2B (NR2B9c). Tat-HA-NR2B9 reduces infarct size and improves neurological functions in ischemia-induced cerebral injury in the rats

HY-P1857

*CEF7, Influenza* Virus NP (380-388)**	Influenza Virus	Infection
CEF7, Influenza Virus NP (380-388) is a HLA-B ^08 restricted influenza* virus nucleoprotein epitope. Influenza virus NP functions as a key adapter molecule between virus and host cell processes .

HY-P1835

*CEF8, Influenza* Virus NP (383-391)**	Influenza Virus	Inflammation/Immunology
CEF8, Influenza Virus NP (383-391), an influenza A virus nucleoprotein containing residues 383 to 391, is the most important HLA-B ^2705-restricted epitope in the nucleoprotein of influenza* A viruses and is associated with escape from cytotoxic T lymphocytes-mediated immunity .

HY-P5476

Influenza virus NP (44-52)	ペプチド	Others
Influenza virus NP (44-52) is a biological active peptide. (HLA-A01 restricted epitope from influenza* virus nucleoprotein (44-52).)

HY-P5478

Influenza virus PA (46-54)	DNA/RNA Synthesis Influenza Virus	Others
Influenza virus PA (46-54) is a biological active peptide. (HLA-A0201 restricted epitope from influenza* virus RNA polymerase subunit, PA (46-54).)

HY-P1580

PA (224-233), Influenza	Influenza Virus	Infection
PA (224-233), Influenza is a 10-aa peptide, a fragment of polymerase 2 protein in influenza A virus.

HY-P0137

CEF1, Influenza Matrix Protein M1 (58-66)	Influenza Virus	Infection
CEF1, Influenza Matrix Protein M1 (58-66) is an epitope derived from the matrix protein of the influenza A virus .

HY-P1736

Influenza HA (126-138)	Influenza Virus	Infection
Influenza HA (126-138) is a influenza virus hemagglutinin (HA) peptide comprising amino acids 126-138, induces thymic and peripheral T-cell apoptosis .

HY-P0304

CEF4	Influenza Virus	Infection
CEF4 is a peptide that corresponds to aa 342-351 of the influenza A virus nucleocapsid protein.

HY-P0313

CEF6	Influenza Virus	Infection
CEF6 is a 9-aa-long peptide corresponding to aa 418-426 of the influenza A virus (H1N1) nucleocapsid protein.

HY-P3823A

Asp-Asp-Asp-Asp-Asp-Asp TFA	Influenza Virus	Infection
Asp-Asp-Asp-Asp-Asp-Asp TFA is a polyaspartic acid. The specificity of the catalytic and antigenic sites of influenza virus neuraminidase is related to the number of specific amino acids.

HY-P11145

Influenza HA (529-537)	Influenza Virus	Infection Inflammation/Immunology
Influenza HA (529-537) is the amino acid sequence (IYATVAGSL) at positions 529-537 of the hemagglutinin (HA) of the influenza A virus. Influenza HA (529-537) can be recognized by three different specificities (H1-specific, H2-specific, H1/H2 cross-reactive) of CD8 ⁺ cytotoxic T-lymphocyte (CTL) clones. Influenza HA (529-537) can be used to understand T-cell immune specificity and to design new vaccines .

HY-P5477

Influenza virus NP (266-274)	ペプチド	Others
Influenza virus NP (266-274) is a biological active peptide. (HLA-A03 restricted epitope from influenza* virus nucleoprotein (265-274).)

HY-P5642A

Retrocyclin-101 TFA RC-101 TFA	HIV SARS-CoV Influenza Virus Flavivirus HSV Bacterial Fungal Toll-like Receptor (TLR) Ser/Thr Protease	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) TFA is an artificially synthesized, cyclic-structured θ-defensin, a broad-spectrum agent with antimicrobial (covering viruses, bacteria, and fungi) activity and anti-inflammatory activity. Retrocyclin-101 TFA can inhibit the serine protease activity of ZIKV NS2B-NS3, with an IC₅₀ of 7.20 μM. Retrocyclin-101 TFA has significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus, etc. Retrocyclin-101 TFA inhibits the signal transduction mediated by TLR4 and TLR2, reducing the expression of pro-inflammatory cytokines .

製品番号	製品名	Target	研究分野	Image

HY-P99853

Diridavumab CR6261	Influenza Virus	Infection
Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus .

HY-P99750

Navivumab CT-P23	Influenza Virus	Infection
Navivumab (CT-P23) is a monoclonal antibody targeting the hemagglutinin (HA) of **influenza A virus*. Navivumab binds to the HA2 stem fusion domain and the low-variability HA2 region of influenza* viruses. Navivumab neutralizes influenza A viruses of subtypes H1, H2, H5, and H9. Navivumab is applicable to research related to influenza and influenza A .

HY-P991446

MEDI-8852	Influenza Virus	Infection
MEDI-8852 is a human IgG1 monoclonal antibody against influenza A virus hemagglutinin (HA). MEDI-8852 binds to the conserved HA stalk epitope and neutralizes viral infectivity. MEDI-8852 reduces viral titers in mouse lung tissues. MEDI-8852 is applicable to research related to pandemic influenza . Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99637

Gedivumab MHAA4549A; RG7745	Influenza Virus	Infection
Gedivumab (MHAA4549A; RG7745) is a human monoclonal antibody that targets influenza A virus (IAV) with high specificity and binds to the highly conserved stem region of the IAV haemagglutinin protein, thereby preventing haemagglutinin maturation and blocking haemagglutinin-mediated membrane fusion in the intranucleosome. Gedivumab can be used in IAV infection disease studies .

HY-P991059

VIS-410	Influenza Virus	Infection
VIS-410 is an antibody inhibitor targeting the stem region of hemagglutinin (HA). VIS-410 inhibits **influenza virus** replication by blocking HA-mediated membrane fusion. VIS-410 exhibits broad-spectrum neutralization against influenza A viruses with group 1 and group 2 hemagglutinins, including subtypes such as H1N1, H3N2, H5N1, and H7N9 (H5N1 IC₅₀ = 1.5 μg/mL). VIS-410 is applicable to research related to influenza A virus infection .

HY-P99620

Firivumab CT-P22; CT120	Influenza Virus	Infection
Firivumab (CT-P22; CT120) is a human IgG1 monoclonal influenza A virus hemagglutinin (Anti-IAV HA) antibody. Firivumab is capable of neutralizing H1N1, H5N1, H6N1, H6N2, H8N4, H8N8, H9N2 and H12N7. Firivumab shows protection against H1N1 virus in mice .

HY-P99699

Lesofavumab MHAB5553A; RG70026	Influenza Virus	Infection
Lesofavumab (MHAB5553A) is a human IgG1κ anti-influenza B virus antibody .

HY-P990187

Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114)	MHC Influenza Virus	Infection Inflammation/Immunology
Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) does not react with I-Af, I-Ak, or I-As haplotypes. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) blocks MHC Class II and inhibit T cell generation. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) can be used for the researches of infection and immunology, such as influenza A virus (IAV) infection .

HY-P990811

*Anti-Influenza* A virus NP Antibody (H16-L10-4R5 (HB-65))**	Influenza Virus	Infection
Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) is mouse-derived IgG2a κ type antibody inhibitor, targeting to influenza virus nucleoprotein. Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) reacts with influenza virus nucleoprotein (NP). Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) can induce passive immunity to influenza A virus. Anti-Influenza A virus NP Antibody (H16-L10-4R5 (HB-65)) can be used for the detections of western blot, flow cytometry and immunohistochemistry in Influenza A virus infection .

HY-P990123

Anti-Mouse ICOSL/CD275 Antibody (HK5.3)	Transmembrane Glycoprotein Influenza Virus	Infection Inflammation/Immunology
Anti-Mouse ICOSL/CD275 Antibody (HK5.3) is an anti-mouse ICOSL/CD275 IgG2a monoclonal antibody. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can inhibit the adhesion between T cells and endothelial cells. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can reduce the expansion of tissue resident (TR) Treg cells. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) can be used for researches on inflammation and infection conditions such as influenza virus infection and arthritis .

HY-P991054

CR-8020	Influenza Virus	Infection
CR-8020 is a human IgG1 antibody that targets influenza A virus H3N2. CR-8020 binds to hemagglutinin (HA) of H3N2 strains with IC₅₀s of 3.36 nM and 0.06 nM for A/Brisbane/10/2007 and A/Wyoming/3/2003, respectively. The isotype control for CR-8020 can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990944

Sonavibart	阻害性抗体	Inflammation/Immunology
HY-P990944 is an influenza A virus hemagglutinin HA-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992083

Anti-Influenza HA Antibody (CR9114)	Influenza Virus	Infection
Anti-Influenza HA Antibody (CR9114) is an antibody against influenza virus hemagglutinin. Anti-Influenza HA Antibody (CR9114) binds to the conserved hemagglutinin (HA) stalk region of influenza A and B viruses, and mediates cross-subtype neutralization. Anti-Influenza HA Antibody (CR9114) is applicable for influenza-related research .

HY-P992079

Anti-Flu A (H3N2) HA/Hemagglutinin Antibody (CR8043)	Influenza Virus	Infection
Anti-Flu A (H3N2) HA/Hemagglutinin Antibody (CR8043) is an antibody targeting influenza virus hemagglutinin (HA) that specifically neutralizes group 2 influenza viruses. Anti-Flu A (H3N2) HA/Hemagglutinin Antibody (CR8043) is applicable to research related to influenza virus infection .

HY-P992080

Anti-Flu A (H7N9) HA/Hemagglutinin Antibody (m826)	Influenza Virus	Infection
Anti-Flu A (H7N9) HA/Hemagglutinin Antibody (m826) is a humanized monoclonal antibody targeting H7N9. Anti-Flu A (H7N9) HA/Hemagglutinin Antibody (m826) induces antibody-dependent cellular cytotoxicity (ADCC) against cells expressing H7N9 HA. Anti-Flu A (H7N9) HA/Hemagglutinin Antibody (m826) is applicable to studies related to H7N9 avian influenza virus infection .

HY-P992078

Anti-Flu A (H3N2) HA/Hemagglutinin Antibody (C05)	Influenza Virus	Infection
Anti-Flu A (H3N2) HA/Hemagglutinin Antibody (C05) is a broad-spectrum neutralizing antibody that targets multiple influenza A HA subtypes. Anti-Flu A (H3N2) HA/Hemagglutinin Antibody (C05) is applicable to research related to influenza A virus infection .

製品番号	製品名	Category	Target	構造式

HY-B0215

Acetylcysteine Maximum Cited Publications 661 Publications Verification N-Acetylcysteine; N-Acetyl-L-cysteine; NAC	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis
Acetylcysteine (N-Acetylcysteine) is a mucolytic agent that can cross the blood-brain barrier, which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza *virus* activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-15230

Geldanamycin 35+ Cited Publications	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Benzene Quinones Inflammation/Immunology Disease Research Fields Source Classification	HSP Bacterial Influenza Virus Antibiotic
Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

HY-N0102

Isoliquiritigenin 30+ Cited Publications GU17; ISL; Isoliquiritigen; SJ000286237	Classification of Application Fields Plants Infection Chalcones Flavonoids Microorganisms Leguminosae Phenols Polyphenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Source Classification	Aldose Reductase Influenza Virus Autophagy Apoptosis
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensis Fisch., which inhibits aldose reductase with an IC₅₀ of 320 nM. Isoliquiritigenin is a potent inhibitor of **influenza virus replication with an EC₅₀** of 24.7 μM.

HY-N0189

Aloe emodin 3 Publications Verification Rhabarberone; 3-Hydroxymethylchrysazine	Quinones Liliaceae Classification of Application Fields Anthraquinones Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Disease Research Fields Source Classification Cancer	mTOR Influenza Virus Apoptosis Autophagy
Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis . Aloe emodin also exhibits antiviral activity that against **influenza A virus** .

HY-B0421

Mycophenolic acid 10+ Cited Publications Mycophenolate	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Dengue Virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including *influenza*. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-117235

Diallyl Trisulfide 3 Publications Verification	Infection 天然物 Liliaceae Classification of Application Fields Anti-aging Allium sativum Linn. Plants Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS) Fungal Apoptosis SOD Bcl-2 Family Influenza Virus Interleukin Related
Diallyl Trisulfide is an orally active anticancer agent that can be isolated from garlic. Diallyl Trisulfide has the ability to induce apoptosis and exhibits anticancer, anti-inflammatory, antioxidant, and antibacterial activities. Diallyl Trisulfide can be used to study a variety of cancers, including liver, colon and prostate cancer .

HY-N0035

Arctigenin 10+ Cited Publications (-)-Arctigenin	Neurological Disease Classification of Application Fields Anti-aging Lignans Metabolic Disease Plants Compositae Caesalpinia magnifoliolata Metc. Endogenous metabolite Infection Human Gut Microbiota Metabolites Phenylpropanoids Inflammation/Immunology Disease Research Fields Source Classification Cancer	MMP Influenza Virus Autophagy Apoptosis
Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .

HY-B0157

Ketotifen 3 Publications Verification HC 20-511	Infection 天然物 Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology Source Classification	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and **Influenza virus**. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N0638

Dendrobine 5+ Cited Publications	Infection Alkaloids Pyrrole Alkaloids Classification of Application Fields Orchidaceae Plants Disease Research Fields Dendrobium nobile Lindl. Source Classification	Influenza Virus JNK p38 MAPK Apoptosis CDK Keap1-Nrf2 SOD Reactive Oxygen Species (ROS)
Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against **influenza A viruses, with IC₅₀s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively. Dendrobine activates the JNK/p38/Nrf2** signaling pathway. Dendrobine exhibits antiviral, antitumor, anti-inflammatory, and neuroprotective properties .

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Source Classification	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis
Urolithin M5 (Decarboxyellagic acid) is an orally active **influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀** values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .

HY-128965

N-Glycolylneuraminic acid NeuGc; GcNeu	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Influenza Virus Endogenous Metabolite
N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs) .

HY-N0482

Phillyrin 5+ Cited Publications	Infection Oleaceae Classification of Application Fields Lignans Phenylpropanoids Forsythia suspensa (Thunb.) Vahl Plants Inflammation/Immunology Disease Research Fields Source Classification	Cytochrome P450 Influenza Virus Bacterial
Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities . Phillyrin has anti-influenza A virus activities .

HY-B0157A

Ketotifen fumarate 3 Publications Verification HC 20511 fumarate	天然物 Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and **Influenza virus**. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-N2532

Diphyllin 3 Publications Verification	Infection Monophenols Classification of Application Fields Lignans Phenols Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Inflammation/Immunology Disease Research Fields Source Classification	VSV HIV Proton Pump Influenza Virus
Diphyllin is an orally active V-ATPase inhibitor (IC₅₀=17 nM) and HIV-1 inhibitor (IC₅₀=0.38 μM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC₅₀=0.6 nM for acid influx inhibition)， thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption .

HY-N0224

Epigoitrin 1 Publications Verification	Alkaloids Classification of Application Fields Other Alkaloids Cruciferae Isatis tinctoria L. Plants Disease Research Fields Source Classification Cancer	Influenza Virus
Epigoitrin is a natural alkaloid that provides protection against influenza infection by reducing the host’s susceptibility to influenza virus under stress. Epigoitrin exerts antiviral activity against influenza A1 virus FM1 via inhibiting virus attachment and multiplication in vitro. Epigoitrin also has lipid-lowering effects .

HY-N0761

Isoferulic acid 3 Publications Verification 3-Hydroxy-4-methoxycinnamic acid	Monophenols Classification of Application Fields Simple Phenylpropanols Ranunculaceae Phenols Metabolic Disease Phenylpropanoids Cimicifuga foetida Linn. Plants Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Influenza Virus
Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is an orally active cinnamic acid derivative. Isoferulic acid exhibits hypoglycemic, antiviral, and antioxidant activities. Isoferulic acid can also inhibit fructose- and glucose-mediated protein glycation. Isoferulic acid can be used in the research of diseases such as diabetes .

HY-Y0136

3-Indoleacetonitrile 2 Publications Verification	天然物 Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Influenza Virus HSV VSV
3-Indoleacetonitrile is an indole derivative with *anti-influenza* activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .

HY-N11630

Pinellic acid	Structural Classification Araceae Ketones, Aldehydes, Acids Plants Pinellia ternata (Thunb.) Breit. Source Classification	Influenza Virus Biochemical Assay Reagents
Pinellic acid is an orally active adjuvant for intranasal influenza vaccines. Pinellic acid can be extracted from the tubers of Pinellia ternata Breitenbach. When administered intranasally in combination with influenza HA vaccine, Pinellic acid slightly increases the titers of antiviral IgG antibodies in bronchoalveolar lavage fluid and serum. Pinellic acid shows no hemolytic activity. Pinellic acid can be used in studies related to influenza virus infection .

HY-B0421A

Mycophenolic acid sodium 10+ Cited Publications Mycophenolate sodium	Infection Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Dengue Virus Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus
Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 µM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including *influenza*. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-N1745A

3-Deoxysappanchalcone 2 Publications Verification	Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Influenza Virus
3-Deoxysappanchalcone is a kinase inhibitor and antiviral agent. 3-Deoxysappanchalcone directly targets MET, EGFR, AKT, mTOR, p38 MAPK, JNK, thrombin, FXa, and influenza virus neuraminidase, thereby regulating related signaling pathways. 3-Deoxysappanchalcone induces cell cycle arrest, ROS production, and apoptosis. 3-Deoxysappanchalcone exhibits anti-inflammatory, anti-allergic, anticoagulant, and antithrombotic activities. 3-Deoxysappanchalcone is applicable to research related to gefitinib-resistant lung cancer, esophageal squamous cell carcinoma, thrombosis, and influenza virus infection .

HY-N4194

Glabrone 1 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Source Classification	PPAR Influenza Virus
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .

HY-N6025

Clemastanin B 1 Publications Verification	Classification of Application Fields Cruciferae Lignans Isatis tinctoria L. Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Influenza Virus
Clemastanin B, a lignin, has potent *anti-influenza* activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities .

HY-N2735

7,3',4'-Trihydroxy-3-benzyl-2H-chromene	Leguminosae Caesalpinia sappan L. Phenols Polyphenols Plants Source Classification	Influenza Virus
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC₅₀ values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus .

HY-I0736

Isonicotinic acid	Alkaloids Aloe africana Liliaceae Other Diseases Pyridine Alkaloids Plants Disease Research Fields Source Classification	MOFs Drug Metabolite Drug Intermediate
Isonicotinic acid is an Isoniazid (HY-B0329) metabolite. The Isonicotinic acid derivative Enisamium inhibits the replication of multiple subtypes of influenza A virus .

HY-135646

Eleutheroside B1	other families Classification of Application Fields Coumarins Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Influenza Virus
Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human **influenza virus efficacy, with an IC₅₀** value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities .

HY-B0421R

Mycophenolic acid (Standard) Mycophenolate (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Dengue Virus Reference Standards Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus
Mycophenolic acid (Standard) is the analytical standard of Mycophenolic acid. This product is intended for research and analytical applications. Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects .

HY-N3016

Rupestonic acid	Other Terpenoids Infection Classification of Application Fields Terpenoids Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Source Classification	Influenza Virus
Rupestonic acid, a sesquiterpene, can inhibit **influenza virus** .

HY-N6055

Nuezhenidic acid	Infection Structural Classification Iridoids Staphyleaceae Classification of Application Fields Terpenoids Plants Disease Research Fields Turpinia arguta (Lindl.) Seem. Source Classification	Influenza Virus
Nuezhenidic acid can be isolated from the fruits of Ligustrum lucidum, posseses inhibitory activities against influenza A virus .

HY-135319

Strictinin	Structural Classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Bacterial Antibiotic ERK JNK NF-κB ROR Apoptosis Caspase GSK-3 Akt PI3K
Strictinin is an orally active phenolic compound. Strictinin reduces xanthine oxidase activity, uric acid production, and the activation of ERK1/2, JNK, NF-κB, and NLRP3 inflammasome components in hepatocytes treated with Xanthine (HY-W017389). Strictinin decreases elevated serum uric acid levels and enhanced xanthine oxidase activity in mice treated with potassium oxonate. Strictinin acts as a ROR1 inhibitor and exhibits anticancer activity against highly aggressive non-androgen-dependent prostate cancer. Strictinin induces cancer cell apoptosis (apoptosis), arrests cell cycle, and inhibits cancer cell migration, invasion, and epithelial-mesenchymal transition. Strictinin modulates gut microbiota, inhibits bacterial growth and biofilm formation, accelerates small intestinal transit, and blocks viral entry and replication. Strictinin can be used in research related to hyperuricemia, androgen receptor-negative non-androgen-dependent prostate cancer, triple-negative breast cancer, bacterial infections, constipation, coronavirus infections, dental caries, and infections caused by influenza A, influenza B, and human parainfluenza virus type 1 .

HY-N0440R

Germacrone (Standard)	Structural Classification Terpenoids Sesquiterpenes Plants Curcuma longa Source Classification Zingiberaceae	Reference Standards Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis
Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 inﬂuenza A viruses and the inﬂuenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity .

HY-B0215R

Acetylcysteine (Standard) N-Acetylcysteine (Standard); N-Acetyl-L-cysteine (Standard); NAC (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis
Acetylcysteine (Standard) is the analytical standard of Acetylcysteine. This product is intended for research and analytical applications. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor . Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases . Acetylcysteine induces cell apoptosis . Acetylcysteine also has anti-influenza virus activities . In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-113806

(±)-Trolline (±)-Oleracein E	Alkaloids Trollius chinensis Bunge Ranunculaceae Pyridine Alkaloids Plants Source Classification	Bacterial Influenza Virus Apoptosis
(±)-Trolline ((±)-Oleracein E), an isoquinoline alkaloid, exhibits antibacterial activity against respiratory bacteria and antiviral activity against influenza virus A and B. (±)-Trolline significantly induces HSC apoptosis. (±)-Trolline can be used for the research of liver fibrosis .

HY-N12110

SMU-CX1	Apocynaceae Alkaloids Other Alkaloids Plants Source Classification	Toll-like Receptor (TLR) SARS-CoV
SMU-CX1 is a specific TLR3 inhibitor (IC₅₀: 0.11 μM) with IC₅₀ ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC₅₀ of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5 .

HY-122920

Soyasaponin II	Triterpenes Classification of Application Fields Leguminosae Terpenoids Plants Inflammation/Immunology Disease Research Fields Glycine soja Sieb. Et Zucc. Source Classification	HSV CMV Influenza Virus HIV NOD-like Receptor (NLR) YB-1
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure .

HY-N10581

Flutimide	Microorganisms	Influenza Virus
Flutimide is a novel endonuclease inhibitor of influenza virus. Flutimide selectively inhibits endonuclease with an IC₅₀ value of 3 μM. Flutimide shows antiviral activity in cell culture. Flutimide can be used for the research of acute contagious respiratory disease, such as influenza .

HY-N7346

Lucidadiol	Triterpenes Microorganisms Terpenoids Source Classification	HSV Cholinesterase (ChE)
Lucidadiol is a natural compound isolated from Ganoderma lucidum. Lucidadiol exhibits acetylcholinesterase-inhibitory activity, with IC₅₀ values of 31 μM. Lucidadiol shows antiviral activity against influenza virus type A and HSV type 1 .

HY-Y0136R

3-Indoleacetonitrile (Standard)	Structural Classification 天然物 Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Influenza Virus HSV VSV
3-Indoleacetonitrile (Standard) is the analytical standard of 3-Indoleacetonitrile. This product is intended for research and analytical applications. 3-Indoleacetonitrile is an indole derivative with *anti-influenza* activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .

HY-N0224A

Goitrin (S)-Goitrin; L-5-Vinyl-2-thiooxazolidone	天然物 Cruciferous vegetables Classification of Application Fields Metabolic Disease Plants Brassicaceae Endogenous metabolite Disease Research Fields Source Classification	Influenza Virus
Goitrin ((S)-Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity .

HY-15230R

Geldanamycin (Standard)	Quinones Structural Classification Microorganisms Benzene Quinones Source Classification	Reference Standards HSP Bacterial Influenza Virus Antibiotic
Geldanamycin (Standard) is the analytical standard of Geldanamycin. This product is intended for research and analytical applications. Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

HY-N10843

4-O-Methylepisappanol	Flavanonols Flavonoids Caesalpiniaceae Plants Source Classification	Influenza Virus
4-O-Methylepisappanol (compound 9) is nature product that could be isolated from heartwood of Caesalpinia sappan. 4-O-Methylepisappanol is a potent neuraminidase inhibitor on the surface of influenza viruses with IC₅₀ values of 42.8, 63.2, and 63.2 µM for A/Chicken/Korea/MS96/96 [H9N2], A/PR/8/34 [H1N1], and A/Hong Kong/8/68 [H3N2], respectively .

HY-129150

Ganoderic acid TR	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Source Classification	Influenza Virus
Ganoderic acid TR is a broad-spectrum inhibitor of influenza neuraminidase enzymes (NAs). Ganoderic acid TR has IC₅₀ values of 10.9 and 4.6 μM for H5N1 and H1N1 NAs, respectively. Ganoderic acid TR is limited by cytotoxicity and shows only weak activity against Oseltamivir (HY-13317)-resistant H1N1 viruses and influenza B viruses .

HY-N0035R

Arctigenin (Standard) (-)-Arctigenin (Standard)	Structural Classification Human Gut Microbiota Metabolites Lignans Phenylpropanoids Plants Compositae Caesalpinia magnifoliolata Metc. Endogenous metabolite Source Classification	Reference Standards MMP Influenza Virus Autophagy Apoptosis
Arctigenin (Standard) is the analytical standard of Arctigenin. This product is intended for research and analytical applications. Arctigenin ((-)-Arctigenin), a biologically active lignan, can be used as an antitumor agent. Arctigenin exhibits potent antioxidant, anti-inflammatory and antiviral (influenza A virus) activities. Arctigenin can be used for the research of metabolic disorders, and central nervous system dysfunctions .

HY-N15389

Noformicin	Microorganisms Antibiotics Other Antibiotics Source Classification	Influenza Virus
Noformicin has inhibitory effect on mumps virus and Newcastle disease virus in chicken embryo. Noformicin also extended the survival of mice infected with swine, influenza A (PR8) and influenza B (Lee) viruses .

HY-P0289

CEF3	Infection 天然物 Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Influenza Virus
CEF3 (SIIPSGPLK) corresponds to aa 13-21 of the influenza A virus M1 protein. The matrix (M1) protein of influenza A virus is a multifunctional protein that plays essential structural and functional roles in the virus life cycle.

HY-N2216

Polygalasaponin XXXI Onjisaponin F	Infection Triterpenes Classification of Application Fields Terpenoids Polygalaceae Plants Polygala tenuifolia Willd. Disease Research Fields Source Classification	Influenza Virus
Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection .

HY-N0224R

Epigoitrin (Standard)	Alkaloids Structural Classification Other Alkaloids Cruciferae Isatis tinctoria L. Plants Source Classification	Influenza Virus Reference Standards
Epigoitrin (Standard) is the analytical standard of Epigoitrin. This product is intended for research and analytical applications. Epigoitrin is a natural alkaloid that provides protection against influenza infection by reducing the host’s susceptibility to influenza virus under stress. Epigoitrin exerts antiviral activity against influenza A1 virus FM1 via inhibiting virus attachment and multiplication in vitro. Epigoitrin also has lipid-lowering effects .

HY-N16441

Pulvic acid	Microorganisms Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite Influenza Virus
Pulvic acid (Compound 3), a butenolide, is a microbial secondary metabolite. Pulvic acid can be isolated from the marine-derived fungus Aspergillus terreus Gwq-48. Pulvic acid has significant antiviral activity with an IC₅₀ of 29.1 μg/mL for influenza A H1N1 virus. Pulvic acid can be used for influenza virus infections research .

HY-N7915

Nepasaikosaponin K	Triterpenes Lychnophora antillana Terpenoids Plants Umbelliferae Source Classification	Influenza Virus
Nepasaikosaponin K is an *anti-influenza* agent. Nepasaikosaponin K shows an EC₅₀ of 17.91 μM against influenza virus A/WSN/33 (H1N1) in 239T-Gluc cells .

HY-N14904

Panosialin D	Microorganisms Antibiotics Other Antibiotics Source Classification	Glycosidase
Panosialin D can inhibit α,β-glucosidase and mannose glycosidase. Panosialin D does not inhibit the influenza virus, but it has weak anti-microbial effect .

HY-N7647

Methyl brevifolincarboxylate Brevifolincarboxylic acid methyl ester	Infection 天然物 Classification of Application Fields Canarium album (Lour.) Rauesch. Plants Burseraceae Disease Research Fields Source Classification	Influenza Virus
Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation .

製品番号	製品名	構造式

HY-B0421S

Mycophenolic acid-d3

Mycophenolic acid-d₃ (Mycophenolate-d₃) is deuterium labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC₅₀ of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

HY-13318S

Oseltamivir acid-d3

Oseltamivir acid-d₃ is a deuterium labeled Oseltamivir acid (HY-13318). Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC₅₀=2 nM) with activity against both influenza A and B viruses. Oseltamivir acid has an extremely weak ability to penetrate the BBB under normal physiological conditions, but its blood-brain barrier penetration is significantly enhanced under inflammatory conditions .

HY-B0215S

Acetylcysteine-d3

Acetylcysteine-d₃ is the deuterium labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-13317S

Oseltamivir-d3
Oseltamivir-d₃ is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-B0272S2

Rifampicin-d4
Rifampicin-d₄ is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-B0272S1

Rifampicin-d8
Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza *virus* activities.

HY-B0402S1

Amantadine-d6

Amantadine-d₆ is the deuterium labeled Amantadine . Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .

HY-B0402S

Amantadine-d15
Amantadine-d₁₅ is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent .

HY-135853S

Molnupiravir-d7

Molnupiravir-d₇ is the deuterium labeled Molnupiravir. Molnupiravir (EIDD-2801) is an orally bioavailable prodrug of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza .

HY-Y0136S1

3-Indoleacetonitrile-d4

3-Indoleacetonitrile-d₄ is deuterium labeled 3-Indoleacetonitrile (HY-Y0136). 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV.

HY-109025AS

Baloxavir-d5
Baloxavir-d₅ is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-B0421S2

Mycophenolic acid-13C17

Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

HY-B0272S

Rifampicin-d3
Rifampicin-d₃ is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities .

HY-B0272S3

Rifampicin-d11
Rifampicin-d₁₁ (Rifampin-d₁₁; Rifamycin AMP-d₁₁) is the deuterium labeled Rifampicin (HY-B0272) . Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza *virus* activities. Rifampicin shows anti-orthopoxvirus activity .

HY-B0510S3

Trimethoprim-13C3

Trimethoprim- ¹³C₃ is the deuterium labeled Trimethoprim (HY-B0510) . Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for the research of urinary tract infections, Shigellosis and Pneumocystis pneumonia. Trimethoprim can inhibit infection of Influenza A virus in chick embryo when combinated with zinc .

HY-W751835

Baloxavir-d4

Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-B0215S1

Acetylcysteine-15N

Acetylcysteine- ¹⁵N (N-Acetylcysteine- ¹⁵N) is the ¹⁵N-labeled Acetylcysteine. Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies .

HY-13317S3

Oseltamivir-d5
Oseltamivir-d₅ is the deuterium labeled Oseltamivir . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀ of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-13317S4

Oseltamivir-d3 hydrochloride
Oseltamivir-d₃ hydrochloride is the deuterium-labeled Oseltamivir (HY-13317) . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-13317S1

Oseltamivir-d3-1
Oseltamivir-d₃-1 is the deuterium labeled Oseltamivir . Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC₅₀s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent .

HY-14904AS

Umifenovir-d6 hydrochloride

Umifenovir-d₆ (hydrochloride) is the deuterium labeled Umifenovir hydrochloride. Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells . Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity .

HY-I0736S

Isonicotinic acid-d4
Isonicotinic acid-d₄ is the deuterium labeled Isonicotinic acid (HY-I0736). Isonicotinic acid is an Isoniazid (HY-B0329) metabolite. The Isonicotinic acid derivative Enisamium inhibits the replication of multiple subtypes of influenza A virus .

HY-13318S1

Oseltamivir acid-13C,d3
Oseltamivir acid-13C,d3 (GS 4071-13C,d3; Ro 64-0802-13C,d3) is a 13C- and deuterium-labeled Oseltamivir acid (HY-13318). Oseltamivir acid is the active metabolite of Oseltamivir phosphate and inhibits influenza virus neuraminidase (IC₅₀=2 nM). Oseltamivir acid is orally active and can be used to study influenza A/B infections .

HY-W713297

Moroxydine hydrochloride-d8

Moroxydine hydrochloride-d₈ (ABOB hydrochloride-d₈) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels ^[1][2][3].

HY-B1589AS

Carbinoxamine-d6 maleate

Carbinoxamine-d₆ (maleate) is the deuterium labeled Carbinoxamine maleate salt. Carbinoxamine maleate salt is a blood-brain barrier-permeable histamine H1 receptor antagonist. Carbinoxamine maleate salt blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. Carbinoxamine maleate salt inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. Carbinoxamine maleate salt can be used in research on allergic rhinitis, influenza, etc.

HY-W653905

Amantadine-d15 hydrochloride

Amantadine-d₁₅ hydrochloride is deuterated labeled Amantadine. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research .

HY-B0532AS

Trifluoperazine-d3 dihydrochloride

Trifluoperazine-d₃ (dihydrochloride) is deuterium labeled Trifluoperazine (dihydrochloride). Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis .

HY-B0157S1

Ketotifen-d3

Ketotifen-d₃ (HC 20-511-d₃) is deuterium labeled Ketotifen. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

HY-B1589S

(±)-Carbinoxamine-d6

(±)-Carbinoxamine-d₆ is the deuterium labeled (±)-Carbinoxamine (HY-B1589) . (±)-Carbinoxamine is a blood-brain barrier-permeable histamine H1 receptor antagonist. (±)-Carbinoxamine blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. (±)-Carbinoxamine inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. (±)-Carbinoxamine can be used in research on allergic rhinitis, influenza, etc.

HY-109025AS2

Baloxavir-d1
Baloxavir-d₁ is the deuterium labeled Baloxavir (HY-109025A). Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .

製品番号	製品名		Classification

HY-186189

OPA-S-S-alkyne		Alkynes
OPA-S-S-alkyne is a cell surface protein-selective labeling agent. OPA-S-S-alkyne selectively labels hyper-reactive extracellular lysines including ROR2 K382 and ENG K285, blocks ENG-BMP9 interaction, and labels purified human serum albumin with minimal bias. OPA-S-S-alkyne can be used for the research of hematologic and influenza A virus infection .

製品番号	製品名		Classification

HY-107201

β-Cyclodextrin 5+ Cited Publications Betadex		Others
β-Cyclodextrin is a cyclic polysaccharide composed of seven units of glucose (α-D-glucopyranose) linked by α-(1,4) type bonds. β-Cyclodextrin has often been used to enhance the solubility of agents. β-Cyclodextrin has anti-influenza virus H1N1 activities.

HY-148511

Vidutolimod CMP-001		CpG ODNs
Vidutolimod (CMP-001) is a virus-like particle containing a TLR9 activator . Vidutolimod induces human peripheral blood mononuclear cells to secrete IFNα, and upregulates the gene expression of CXCL10, PDL1, IDO and CD80. Vidutolimod activates TLR9, which in turn triggers plasmacytoid dendritic cell activation, production of IFNγ and TNFα, induction of CXCL10, and recruitment of antitumor T cells. Vidutolimod causes influenza-like symptoms, hypotension and tumor regression, and its activity depends on the presence of anti-Qβ antibodies. Vidutolimod modulates monocyte function, promotes CD4 T cell proliferation, and activates multiple immune cell types in an environment with anti-Qβ antibodies. Vidutolimod prolongs the survival of tumor-bearing mice. Vidutolimod is used in research related to advanced melanoma, head and neck squamous cell carcinoma, and advanced non-small cell lung cancer .

HY-177637

H5N1 aptamer sodium		Aptamers
H5N1 aptamer sodium is a DNA aptamer targeted to H5N1 Avian Influenza Virus.

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