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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
mast cell degranulation inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "mast cell degranulation inhibitor" in MCE Product Catalog:
6
6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
1
1 Cited Publications
Cat. No.: HY-172458
CAS No.: 473687-20-6
Research Areas:
Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity, exhibiting a KD value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of β-hexosaminidase, significantly reduces the release of histamine and TNF-α, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions .
Synonyms: D-Citronellol; (R)-(+)-β-Citronellol
Category:
Other Monoterpenes Terpenoids Pelargonium hortorum Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology Geraniaceae
Target:
Synonyms: LRCL 3794
Target:
Research Areas:
Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms .
Cat. No.: HY-N0078
CAS No.: 20261-38-5
Synonyms: Ginkgolic acid (13:0); Ginkgoneolic Acid; 6-Tridecylsalicylic acid
Category:
other families Artemisia douglasiana Plants Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-N4207
CAS No.: 14348-21-1
Category:
Other Diseases Coumarins Phenylpropanoids Plants Umbelliferae Disease Research Fields Echinacea angustifolia DC.
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Cat. No.: HY-124146
CAS No.: 1319738-39-0
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Research Areas:
BI1002494 is an orally active, potent, and selective spleen tyrosine kinase (SYK) inhibitor. BI 1002494 exhibits an IC50 of 115 nM in inhibiting high-affinity IgE receptor-mediated mast cell and basophil degranulation. BI1002494 can be utilized in immunology reesearch .
Cat. No.: HY-165528
CAS No.: 1464897-15-1
Synonyms: XC8
Target:
Research Areas:
Histamine glutarimide (XC8) is an orally active anti-asthma agent. Histamine glutarimide blocks the maturation of chemokines (CCL2, CCL7, CCL8, CCL13) and inhibits the migration of eosinophils and the degranulation of mast cells. In asthma models induced by carrageenan and rat ovalbumin, Histamine glutarimide can reduce airway resistance and the count of eosinophils in bronchoalveolar lavage fluid. Histamine glutarimide can be used in asthma research .
Cat. No.: HY-176767
CAS No.: 2792202-91-4
Research Areas:
MrgprX2-IN-1 (Compound 2-10) is a selective Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist. MrgprX2-IN-1 blocks IgE-independent immune responses by inhibiting MRGPRX2-mediated mast cell degranulation and release of inflammatory mediators. MrgprX2-IN-1 is promising for research of pseudo-allergic reactions, chronic pruritus, and inflammatory diseases .
Cat. No.: HY-176768
CAS No.: 2792205-87-7
Research Areas:
MrgprX2-IN-2 (Compound example 12) is a selective Mas-related G-protein coupled receptor X2 (MRGPRX2) antagonist. MrgprX2-IN-2 blocks IgE-independent immune responses by inhibiting MRGPRX2-mediated mast cell degranulation and release of inflammatory mediators. MrgprX2-IN-2 is promising for research of pseudo-allergic reactions, chronic pruritus, and inflammatory diseases .
Cat. No.: HY-N4207R
CAS No.: 14348-21-1
Target:
Cat. No.: HY-106306
CAS No.: 90749-32-9
Synonyms: S 9795
Target:
Research Areas:
Laprafylline (S 9795), a xanthine derivative, is a bronchodilator. Laprafylline has potent anti-bronchoconstrictive effects, inhibiting action on mast cell degranulation and phosphodiesterase (PDE) activity (IC50 of 6 μM) .
Cat. No.: HY-N15423
CAS No.: 18904-40-0
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Cat. No.: HY-161815
Target:
Research Areas:
Anti-inflammatory agent 89 is a multi-target glucocorticoid-isothiocyanate hybrid with anti-inflammatory activity. Anti-inflammatory agent 89 releases hydrogen sulfide via its isothiocyanate group, inhibits antigen-induced mast cell degranulation, alleviates pulmonary inflammation, and suppresses bronchial hyperresponsiveness and airway fibrosis. Anti-inflammatory agent 89 can be used in asthma research .
Cat. No.: HY-158316
CAS No.: 2758569-43-4
Target:
Research Areas:
BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC50 of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumin, low endotoxin (HY-W250978A)-induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability .
Cat. No.: HY-N16668
CAS No.: 718638-77-8
Target:
Cat. No.: HY-N0078R
CAS No.: 20261-38-5
Synonyms: Ginkgolic acid (13:0) (Standard); Ginkgoneolic Acid (Standard); 6-Tridecylsalicylic acid (Standard)
Target:
Cat. No.: HY-185402
CAS No.: 3116848-78-0
Research Areas:
MrgprX2 antagonist-10 is a potent MRGPRX2 antagonist. MrgprX2 antagonist-10 inhibits MRGPRX2-mediated accumulation and mast cell degranulation (IC50 < 100 nM), thereby blocking mast cell activation. MrgprX2 antagonist-10 can be used in research on MRGPRX2-related inflammatory and allergic diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
