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Results for "

normotensive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Cannabinoid Receptor (1) Carbonic Anhydrase (2) Drug Intermediate (1) Endothelin Receptor (1) Guanylate Cyclase (1) Histamine Receptor (1) LPL Receptor (1) Neuropeptide Y Receptor (1) Nucleoside Antimetabolite/Analog (1) Platelet-activating Factor Receptor (PAFR) (1) Prostaglandin Receptor (3) Reference Standards (1) Renin (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (16) Metabolic Disease (1) Neurological Disease (5)

By Targets:

Adrenergic Receptor (1)

Angiotensin Receptor (2)

Angiotensin-converting Enzyme (ACE) (1)

Cannabinoid Receptor (1)

Carbonic Anhydrase (2)

Drug Intermediate (1)

Endothelin Receptor (1)

Guanylate Cyclase (1)

Histamine Receptor (1)

LPL Receptor (1)

Neuropeptide Y Receptor (1)

Nucleoside Antimetabolite/Analog (1)

Platelet-activating Factor Receptor (PAFR) (1)

Prostaglandin Receptor (3)

Reference Standards (1)

Renin (2)

By Research Areas:

Cancer (1)

Cardiovascular Disease (16)

Metabolic Disease (1)

Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19431

Ro 46-8443	Endothelin Receptor	Cardiovascular Disease
Ro 46-8443 is the first non-peptide endothelin ET_B receptor selective antagonist. Ro 46-8443 displays an at least 100-fold selectivity for ET_B (IC₅₀: 34-69 nM) over ET_A receptors (IC₅₀: 6800 nM) .

HY-N9113

1,3,5,6-Tetrahydroxyxanthone	Others	Cardiovascular Disease
1,3,5,6-Tetrahydroxyxanthone is a natural xanthone that can be isolated from Garcinia achachairu Rusby (Clusiaceae) branches. 1,3,5,6-Tetrahydroxyxanthone induces diuresis and saluresis in normotensive and hypertensive rats .

HY-153369

BAY-747 BAY 1165747	Guanylate Cyclase	Cardiovascular Disease Neurological Disease
BAY-747 (BAY 1165747) is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model .

HY-116161A

17-Phenyl trinor PGF2α isopropyl ester	Prostaglandin Receptor	Metabolic Disease
17-Phenyl trinor PGF₂α isopropyl ester is a FP receptor agonist and intraocular pressure-lowering agent. 17-Phenyl trinor PGF₂α isopropyl ester induces iris sphincter contraction, reduces intraocular pressure and pupil diameter, causes no ocular irritation, and only leads to mild conjunctival hyperemia. 17-Phenyl trinor PGF₂α isopropyl ester is applicable to relevant research on glaucoma .

HY-116161

Bimatoprost isopropyl ester	Drug Intermediate	Cardiovascular Disease Others
15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC₅₀ values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.

HY-19145

PD-134672 CI-992	Renin	Cancer
PD-134672 (CI-992) is a renin inhibitor containing a 2-amino-4-thiazolyl substituent. PD-134672 potently inhibits monkey renin in vitro and only weakly inhibits the related aspartic protease bovine feline hepsin D. The compound exhibits oral hypotensive activity in hyperreninemic normotensive monkeys. Based on its superior efficacy and long-lasting effects in vitro and in the normotensive macaque model, PD-134672 was selected for further evaluation in renal hypertensive monkeys.

HY-N4209

3α-Dihydrocadambine	Others	Cardiovascular Disease
3α-Dihydrocadambine is a natural product isolated from the heartwoods of Anthocephalus cadamba.3α-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats .

HY-19155A

ICI-D 8731 ZD-8731	Angiotensin Receptor	Cardiovascular Disease
ICI-D 8731 (compound 5g) is a angiotensin II receptor antagonist with the IC₅₀ of 0.031 μM. ICI-D 8731 shows a rapid and sustained lowering of blood pressure in a renal hypertensive rat model .

HY-144705

GAT564	Cannabinoid Receptor	Neurological Disease
GAT564 (Compound 15d) is a potent allosteric modulator of cannabinoid 1 receptor (CB1R) with EC₅₀s of 87 and 320 nM respectively for cAMP and β-arrestin2. GAT564 markedly promotes orthosteric ligand binding to hCB1R. GAT564 is efficacious as a topical agent that significantly reduces intraocular pressure (IOP) in the ocular normotensive murine model of glaucoma .

HY-117913

ES-8891	Renin	Cardiovascular Disease
ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis .

HY-126115

15(S)-Latanoprost 15-epi Latanoprost	Prostaglandin Receptor	Cardiovascular Disease Others
15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC₅₀ values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.

HY-126115R

15(S)-Latanoprost (Standard) 15-epi Latanoprost (Standard)	Prostaglandin Receptor Reference Standards	Cardiovascular Disease Others
15(S)-Latanoprost (Standard) is the analytical standard of 15(S)-Latanoprost. This product is intended for research and analytical applications. 15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.

HY-182418

UR-11353	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
UR-11353 is a selective platelet activating factor (PAF) antagonist with long-lasting activity. UR-11353 inhibits PAF-induced platelet aggregation in rabbit platelet-rich plasma. UR-11353 inhibits PAF-induced hypotension in normotensive rats. UR-11353 protects against PAF-induced mortality in mice .

HY-182426

NCX-278	Carbonic Anhydrase	Neurological Disease
NCX-278 is a human carbonic anhydrase inhibitor with a 13 nM K_i for hCA II, 410 nM K_i for hCA I, 181 nM K_i for hCA IV, and selective inhibition of hCA II over hCA IV. NCX-278 is a potent and effective stimulator of NO/sGC/cGMP signaling with an EC₅₀ of 2.05 lM. NCX-278 exerts NO-mediated vascular relaxant effects. NCX-278 lowers intraocular pressure in normotensive rabbits. NCX-278 can be used for the research of open-angle glaucoma .

HY-180696

Adenosine tetraphosphate	Nucleoside Antimetabolite/Analog	Neurological Disease
Adenosine tetraphosphate is a natural nucleotide present in many biological systems. Adenosine tetraphosphate produces a reduction in the intraocular pressure in normotensive rabbit eyes .

HY-105527

Flavodilol	Adrenergic Receptor	Cardiovascular Disease
Flavodilol is an orally active antihypertensive agent. Flavodilol extensively depletes catecholamines and serotonin in heart tissue of normotensive and spontaneously hypertensive rats (SHR). Flavodilol can be used for hypertension research .

HY-P11411

[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat	Neuropeptide Y Receptor Histamine Receptor	Cardiovascular Disease
[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat is a fragment analogue of a neuropeptide Y (NPY) with cardiovascular activity. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can induce profound and sustained hypotension in both hypertensive and normotensive rats and its antihypertensive effect is partly attributed to its activity on histamine receptor. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can be used for studying antihypertensive effects .

HY-182407

CV 5975	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
CV 5975 is an orally active angiotensin converting enzyme (ACE) competitive inhibitor with a rabbit lung ACE IC₅₀ of 3.1 nM and K_i values of 2.6 nM. CV 5975 inhibits ACE in plasma, aorta, kidney, and brain, intensifying inhibition with repeated administration. CV 5975 inhibits Angiotensin I (HY-P1032)-induced pressor responses and ileum contraction, and augments bradykinin-induced ileum contraction and depressor responses. CV 5975 reduces blood pressure via ACE-independent mechanisms, with sustained action across multiple hypertensive and normotensive animal models, intensified by repeated dosing or Hydrochlorothiazide (HY-B0252) co-administration. CV 5975 can be used for the research of hypertension .

HY-W566406

Aminozolamide	Carbonic Anhydrase	Neurological Disease
Aminozolamide is a carbonic anhydrase inhibitor. Aminozolamide regulates intraocular pressure by inhibiting carbonic anhydrase activity. Aminozolamide exerts local ocular effects, exhibits good retention in the ciliary body of rabbit eyes, and prevents rapid elimination from the eye. Aminozolamide is applicable to the research of ocular hypertension .

HY-W040167

VPC 23153	LPL Receptor	Cardiovascular Disease
VPC 23153 is a S1P₄ receptor agonist and vasoconstrictor. VPC 23153 activates the S1P₄ receptor, thereby triggering vasoconstriction. VPC 23153 induces pulmonary artery contraction. VPC 23153 can be used in studies related to pulmonary arterial hypertension .

HY-180401

DMP 811	Angiotensin Receptor	Cardiovascular Disease
DMP 811 is a potent, orally active and selective angiotensin II subtype receptor AT1 antagonist. DMP 811 exhibits selectivity for AT1 (IC₅₀ =6 nM) over AT2 (IC₅₀ >10 μM). DMP 811 exhibits potent antihypertensive activity in rats and dogs. DMP 811 can be used for the research of hypertension .

Cat. No.	Product Name	Target	Research Area

HY-110183

Angiotensin A	Peptides	Cardiovascular Disease
Angiotensin A is a renin–angiotensin system (RAS) peptide that causes a vasoconstrictive effect dependent on AT₁ receptors. Angiotensin A elicits pressor and renal vasoconstrictor responses in normotensive and hypertensive rats .

HY-P11411

[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat	Neuropeptide Y Receptor Histamine Receptor	Cardiovascular Disease
[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat is a fragment analogue of a neuropeptide Y (NPY) with cardiovascular activity. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can induce profound and sustained hypotension in both hypertensive and normotensive rats and its antihypertensive effect is partly attributed to its activity on histamine receptor. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can be used for studying antihypertensive effects .

1,3,5,6-Tetrahydroxyxanthone	Flavonoids Guttiferae Hyperlcurn perforatum L. Plants Other Flavonoids Source Classification	Others
1,3,5,6-Tetrahydroxyxanthone is a natural xanthone that can be isolated from Garcinia achachairu Rusby (Clusiaceae) branches. 1,3,5,6-Tetrahydroxyxanthone induces diuresis and saluresis in normotensive and hypertensive rats .

3α-Dihydrocadambine	Uncaria tomentosa (Willd. ex Schult.) DC. Alkaloids Other Alkaloids Rubiaceae Plants Source Classification	Others
3α-Dihydrocadambine is a natural product isolated from the heartwoods of Anthocephalus cadamba.3α-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats .

Adenosine tetraphosphate	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
Adenosine tetraphosphate is a natural nucleotide present in many biological systems. Adenosine tetraphosphate produces a reduction in the intraocular pressure in normotensive rabbit eyes .

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