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Results for "

nucleic acid leakage

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-173238
    Antibacterial agent 273

    		Bacterial Reactive Oxygen Species (ROS) Infection
    Antibacterial Agent 273 (Compound 15e) is a membrane-targeting antimicrobial agent that disrupts bacterial cell membranes, exhibiting a MIC of 4 μg/mL against Staphylococcus aureus. By compromising membrane integrity, it induces leakage of intracellular nucleic acids and proteins, suppresses bacterial metabolic activity, and triggers the accumulation of reactive oxygen species (ROS). Antibacterial Agent 273 is suitable for research on infections caused by Staphylococcus aureus .
    Antibacterial agent 273
  • HY-170991
    C12-rrw-NH2

    		Bacterial Reactive Oxygen Species (ROS) Infection
    C12-rrw-NH2 (Compound Lip7) is an antibacterial agent against gram-positive bacteria, especially against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). C12-rrw-NH2 induces bacterial death via depolarizing the bacterial cytoplasmic membrane, disrupting the integrity of the bacterial membrane, leading to leakage of nucleic acid and protein and promoting the generation of Reactive Oxygen Species. C12-rrw-NH2 is potential to be used for research of developing high-stability antimicrobial peptides .
    C12-rrw-NH2
  • HY-N16448
    Xanthoascin

    		Bacterial Infection
    Xanthoascin (Compound 1) is a natural phenolic metabolite with strong anti plant pathogen activity. Xanthoascin can be extracted from the solid fermentation product of endophytic fungus Aspergillus sp. IFB-YXS isolated from Ginkgo biloba leaves. Xanthoascin has a MIC of 0.3125 µg/mL against Clavibacter michiganense subsp. Sepedonicus and moderate inhibitory activity against other pathogens (MIC = 5-20 µg/mL). Xanthoascin can disrupt the permeability of bacterial cell membranes, leading to nucleic acid leakage .
    Xanthoascin
  • HY-180125A
    Antibacterial agent 307 hydrochloride

    		Bacterial Reactive Oxygen Species (ROS) Infection
    Antibacterial agent 307 hydrochloride is an antibacterial agent. Antibacterial agent 307 hydrochloride shows MICs of 1-4 μg/mL against Gram-positive bacteria, moderate activity against Gram-negative bacteria, low hemolytic toxicity, and excellent plasma stability. Antibacterial agent 307 hydrochloride compromises bacterial membrane integrity via increased permeability and depolarization, induces endogenous ROS accumulation, causes cytoplasmic protein and nucleic acid leakage, and drives rapid bacterial cell death. Antibacterial agent 307 hydrochloride can be used for the research of bacterial infection .
    Antibacterial agent 307 hydrochloride
  • HY-180125
    Antibacterial agent 307

    		Bacterial Reactive Oxygen Species (ROS) Infection
    Antibacterial agent 307 is an antibacterial agent. Antibacterial agent 307 shows MICs of 1-4 μg/mL against Gram-positive bacteria, moderate activity against Gram-negative bacteria, low hemolytic toxicity, and excellent plasma stability. Antibacterial agent 307 compromises bacterial membrane integrity via increased permeability and depolarization, induces endogenous ROS accumulation, causes cytoplasmic protein and nucleic acid leakage, and drives rapid bacterial cell death. Antibacterial agent 307 can be used for the research of bacterial infection .
    Antibacterial agent 307
  • HY-135223
    Chondrillasterol

    		Bacterial Infection
    Chondrillasterol is a sterol that can be isolated from Vernonia adoensis. Chondrillasterol exhibits antibacterial activity. Chondrillasterol inhibits growth of Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Chondrillasterol inhibits formation of bacterial biofilms. Chondrillasterol can be used for the research of bacterial infections .
    Chondrillasterol
  • HY-183340
    Antibacterial agent 341

    		Bacterial Infection
    Antibacterial agent 341 is an anti-bacterial agent. Antibacterial agent 341 shows broad-spectrum Gram-positive antibacterial activity. Antibacterial agent 341 targets phosphatidylglycerol (PG) and cardiolipin (CL) in bacterial cell membranes, induces sustained depolarization of membranes, and disrupts the cell membrane integrity. Antibacterial agent 341 exhibits anti-infection activity against S. aureus-induced subcutaneous abscesses in mice .
    Antibacterial agent 341

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