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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
nucleolar
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "nucleolar" in MCE Product Catalog:
8
8 Publications Verification
Cat. No.: HY-W011793
CAS No.: 13957-31-8
Target:
Research Areas:
4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response .
5
5 Cited Publications
WDR5-IN-4 (Compound C6) is a WIN site inhibitor of chromatin-associated WD repeat domain 5 protein (WDR5), Kd The value is 0.1 nM. WDR5-IN-4 is able to displace WDR5 from chromatin and reduce the expression of related genes, causing translation inhibition and nucleolar stress. Has anti-cancer effects .
5
5 Cited Publications
WDR5-IN-4 TFA (Compound C6) is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity .
Cat. No.: HY-173523
CAS No.: 3054009-82-1
KI-CDK9d-32 is a selective CDK9 PROTAC degrader (IC50 = 3 nM; DC50 = 0.89 nM). KI-CDK9d-32 induces CDK9 degradation via the ubiquitin-proteasome pathway to abrogates CDK9 enzymatic and scaffolding functions, downregulates MYC expression and MYC-dependent signaling, represses TNF-alpha signaling pathways activity and pre-rRNA levels. KI-CDK9d-32 disrupts nucleolar homeostasis, blocks cell cycle progression and cellular translation by reducing 4EBP1 phosphorylation, and elicits cancer cell cytotoxicity in a CRBN-dependent manner, while high ABCB1 activity attenuates the efficacy. KI-CDK9d-32 can be used for the research of acute lymphoblastic leukemia, rhabdomyosarcoma, pancreatic adenocarcinoma .
Synonyms: ML246
Target:
Research Areas:
Metarrestin (ML246) is an orally active, first-in-class and specific perinucleolar compartment inhibitor. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin blocks metastatic development and extends survival in mouse cancer models .
Cat. No.: HY-118723
CAS No.: 309726-06-5
Target:
Research Areas:
BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types .
Cat. No.: HY-W011793R
CAS No.: 13957-31-8
Research Areas:
4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response .
Cat. No.: HY-P71574
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NPM1; Numatrin; Nucleophosmin 1; B23; Nucleophosmin; Nucleophosmin (nucleolar Phosphoprotein B23, Numatrin); NPM; Nucleophosmin/Nucleoplasmin Family, Member 1; nucleolar Phosphoprotein B23; Testicular Tissue Protein Li 128; nucleolar Protein NO38; Mutant
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P7540
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NOL3; nucleolar Protein Of 30 KDa; nucleolar Protein 3; CARD2; ARC; NOP; NOP30; MYOCL1; MYP; Nop30; nucleolar Protein 3 (Apoptosis Repressor With CARD Domain); FCM; Muscle-Enriched Cytoplasmic Protein; Myp; Apoptosis Repressor With CARD
Species:
Human
Source:
E. coli
Cat. No.: HY-P74681
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NPM1; Numatrin; Nucleophosmin 1; B23; Nucleophosmin; Nucleophosmin (nucleolar Phosphoprotein B23, Numatrin); NPM; Nucleophosmin/Nucleoplasmin Family, Member 1; nucleolar Phosphoprotein B23; Testicular Tissue Protein Li 128; nucleolar Protein NO38; Mutant
Species:
Human
Source:
E. coli
Cat. No.: HY-P74680A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NPM1; Numatrin; Nucleophosmin 1; B23; Nucleophosmin; Nucleophosmin (nucleolar Phosphoprotein B23, Numatrin); NPM; Nucleophosmin/Nucleoplasmin Family, Member 1; nucleolar Phosphoprotein B23; Testicular Tissue Protein Li 128; nucleolar Protein NO38; Mutant
Species:
Human
Source:
E. coli
Cat. No.: HY-P811918
Synonyms: PNAS-5, LYAR, Cell growth-regulating nucleolar protein
Cat. No.: HY-P74680
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: NPM1; Numatrin; Nucleophosmin 1; B23; Nucleophosmin; Nucleophosmin (nucleolar Phosphoprotein B23, Numatrin); NPM; Nucleophosmin/Nucleoplasmin Family, Member 1; nucleolar Phosphoprotein B23; Testicular Tissue Protein Li 128; nucleolar Protein NO38; Mutant
Species:
Human
Source:
E. coli
Cat. No.: HY-P811918A
Synonyms: PNAS-5, LYAR, Cell growth-regulating nucleolar protein
Cat. No.: HY-P705533
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DDX21; DEAD-Box Helicase 21; DExD-Box Helicase 21; DEAD (Asp-Glu-Ala-Asp) Box Helicase 21; Gu-Alpha; RNA Helicase II/Gu Alpha; nucleolar RNA Helicase 2; DDX21 Protein; nucleolar RNA Helicase Gu; RNA Helicase; nucleolar RNA Helicase II; Gu Protein; DEAD Bo
Species:
Human
Source:
E. coli
Cat. No.: HY-P705069
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MIDN; Stx; Midnolin; Stuxnet Homolog (Drosophila); Midbrain nucleolar Protein; Stuxnet Homolog
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
