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Results for "

nucleotide metabolism

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Mitochondrial Metabolism (2) Adenosine Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Antifolate (2) Apoptosis (6) Bacterial (2) Biochemical Assay Reagents (3) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (11) Drug Metabolite (1) Endogenous Metabolite (23) Environmental Pollutants (1) Fluorescent Dye (1) HSV (1) iGluR (2) Isotope-Labeled Compounds (10) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Mitosis (6) NTPDase (1) Nucleoside Antimetabolite/Analog (1) P2Y Receptor (2) Parasite (3) Phosphodiesterase (PDE) (1) Prostaglandin Receptor (1) Pyk2 (1) Reference Standards (6) STAT (2) Thymidylate Synthase (4)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Infection (11) Metabolic Disease (18) Neurological Disease (3)
Click Chemistry:	Azide (1)
Oligonucleotides:	Nucleotide Analogs (3) Nucleoside Analogs (1) Uridine (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Mitochondrial Metabolism HCN Channel SOS1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013046

Phosphoribosyl pyrophosphate pentasodium PRPP pentasodium	Endogenous Metabolite	Others
Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP .

HY-N5134

5'-Guanylic acid 2 Publications Verification 5'-GMP; 5'-guanosine monophosphate	Endogenous Metabolite iGluR	Neurological Disease Metabolic Disease
5'-Guanylic acid is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid also causes neuronal cell death at high concentrations .

HY-114364

UDP-Galactose disodium 4 Publications Verification	Endogenous Metabolite P2Y Receptor	Metabolic Disease
UDP-Galactose disodium is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose disodium is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose disodium can be used to study cell signal transduction and substance metabolism .

HY-D0186

2'-Deoxyuridine 3 Publications Verification	Endogenous Metabolite Thymidylate Synthase	Infection
2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .

HY-W010970

5'-Guanylic acid disodium salt 2 Publications Verification 5'-GMP disodium salt; 5'-guanosine monophosphate disodium salt	Endogenous Metabolite iGluR	Neurological Disease Metabolic Disease
5'-Guanylic acid disodium salt is the disodium salt form of 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid disodium salt is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid disodium salt regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid disodium salt is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid disodium salt also causes neuronal cell death at high concentrations .

HY-B1162

Sulisobenzone 1 Publications Verification Benzophenone-4	Environmental Pollutants Biochemical Assay Reagents	Metabolic Disease
Sulisobenzone (Benzophenone-4) is a benzophenone-type UV filter. Sulisobenzone can act as a endocrine disrupting compound. Sulisobenzone disrupts energy metabolism, nucleotide synthesis, oxidative stress response, and endocrine function. Sulisobenzone thyroid hormone biosynthesis and induces oxidative stress .

HY-W011012

Adenosine 5'-monophosphate disodium 15+ Cited Publications	Adenosine Receptor	Metabolic Disease
Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-12784A

Cycloguanil hydrochloride 3 Publications Verification Chlorguanide triazine hydrochloride	Antifolate Parasite DNA/RNA Synthesis STAT	Infection Cancer
Cycloguanil (Chlorguanide triazine) hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-128738

Thymidine-5'-monophosphate disodium salt 1 Publications Verification TMP disodium salt	Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury .

HY-113225

Guanosine triphosphate GTP	Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis	Cancer
Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-138825

NCGC00188636	Pyk2	Metabolic Disease
NCGC00188636 is a novel covalent pyruvate kinase (PYK) inhibitor. NCGC00188636 blocks nucleotide binding to the active site of pyruvate kinase. NCGC00188636 can be used for the research of the metabolism of many organisms and cell types.

HY-150524

UDP-Galactose	Endogenous Metabolite P2Y Receptor	Metabolic Disease
UDP-Galactose is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose can be used to study cell signal transduction and substance metabolism .

HY-N5134R

5'-Guanylic acid (Standard) 5'-GMP (Standard); 5'-guanosine monophosphate (Standard)	Reference Standards Endogenous Metabolite
5'-Guanylic acid is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid also causes neuronal cell death at high concentrations .

HY-147309

16-Azidohexadecanoic acid	Fluorescent Dye	Others
16-Azidohexadecanoic acid, a synthetic fatty acid, can be used as a modification marker for nucleotides and a molecular probe for fatty acid metabolism . 16-Azidohexadecanoic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-113225S2

Guanosine triphosphate-13C dilithium GTP-13C dilithium	Isotope-Labeled Compounds Endogenous Metabolite Mitosis Apoptosis DNA/RNA Synthesis	Infection Cancer
Guanosine triphosphate- ¹³C (GTP- ¹³C) dilithium is ¹³C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S3

Guanosine triphosphate-15N5 dilithium GTP-15N5 dilithium	Isotope-Labeled Compounds Endogenous Metabolite Mitosis Apoptosis DNA/RNA Synthesis	Infection Cancer
Guanosine triphosphate- ¹⁵N₅ (GTP- ¹⁵N₅) dilithium is ¹⁵N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S5

Guanosine triphosphate-13C10 dilithium GTP-¹³C₁₀ dilithium	Isotope-Labeled Compounds Endogenous Metabolite Mitosis Apoptosis DNA/RNA Synthesis	Infection Cancer
Guanosine triphosphate- ¹³C₁₀ (GTP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113143AS

Galactose 1-phosphate-13C potassium	Endogenous Metabolite	Metabolic Disease
Galactose 1-phosphate- ¹³C (potassium) is the ¹³C labeled Galactose 1-phosphate Potassium salt. Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sug .

HY-113143AS1

Galactose 1-phosphate-13C-1 potassium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Galactose 1-phosphate- ¹³C-1 (potassium) is the ¹³C labeled Galactose 1-phosphate Potassium salt. Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sug .

HY-114364S

UDP-α-D-Galactose-13C disodium	Isotope-Labeled Compounds	Others
UDP-α-D-Galactose- ¹³C disodium is the ¹³C labeled UDP-α-D-Galactose disodium. UDP-Galactose disodium is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose disodium is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose disodium can be used to study cell signal transduction and substance metabolism .

HY-130588

Glutathione arsenoxide GSAO	Mitochondrial Metabolism	Cancer
Glutathione arsenoxide (GSAO) is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide targets *Mitochondrial endomycin nucleotide* transferase (ANT). Glutathione arsenoxide causes cell proliferation arrest and cell death. Glutathione arsenoxide can be used to identify cell-surface proteins, such as Protein disulphide isomerase** .

HY-W011012S

Adenosine 5'-monophosphate-13C disodium	Isotope-Labeled Compounds	Others
Adenosine 5'-monophosphate- ¹³C (disodium) is a ¹³C-labeled Adenosine 5'-monophosphate (HY-W011012). Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-130588A

Glutathione arsenoxide TFA GSAO TFA	Mitochondrial Metabolism	Cancer
Glutathione arsenoxide (GSAO) TFA is a potential anticancer agent and a tumour metabolism inhibitor. Glutathione arsenoxide TFA targets *Mitochondrial endomycin nucleotide* transferase (ANT). Glutathione arsenoxide TFA causes cell proliferation arrest and cell death. Glutathione arsenoxide TFA can be used to identify cell-surface proteins, such as Protein disulphide isomerase** .

HY-D0186R

2'-Deoxyuridine (Standard)	Reference Standards Endogenous Metabolite Thymidylate Synthase	Infection
2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine. This product is intended for research and analytical applications. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) . In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine . Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min . In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain . 2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model .

HY-134529

D-Ribofuranose1-dihydrogenphosphate Ribose 1-phosphate	Endogenous Metabolite	Others
D-Ribofuranose 1-dihydrogenphosphate (Ribose 1-phosphate) dicyclohexanamine is a pentose phosphate and serves as a key intermediate metabolite in the salvage synthesis pathway of purine and pyrimidine nucleotides. In nucleotide salvage synthesis, D-Ribofuranose 1-dihydrogenphosphate dicyclohexanamine directly "transfers" the ribosyl group from purine nucleosides to pyrimidine bases, acting as a hub molecule linking nucleoside/base metabolism with pentose phosphate metabolism .

HY-12784

Cycloguanil Chlorguanide triazine	Antifolate DNA/RNA Synthesis STAT Parasite	Infection Cancer
Cycloguanil (Chlorguanide triazine) is a dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ of 10.8 μM against human DHFR. Cycloguanil blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .

HY-113225S1

Guanosine triphosphate-13C10,15N5 tetraammonium solution (100 mM) GTP-¹³C₁₀,¹⁵N₅ tetraammonium	Endogenous Metabolite Mitosis Apoptosis DNA/RNA Synthesis	Cancer
Guanosine triphosphate- ¹³C₁₀, ¹⁵N₅ tetraammonium is the ¹³C and ¹⁵N labeled Guanosine triphosphate tetraammonium. Guanosine triphosphate tetraammonium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate tetraammonium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate tetraammonium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate tetraammonium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate tetraammonium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S4

Guanosine triphosphate-15N5,d14 dilithium GTP-15N5,d14 dilithium	Isotope-Labeled Compounds Endogenous Metabolite Mitosis Apoptosis DNA/RNA Synthesis	Infection Cancer
Guanosine triphosphate- ¹⁵N₅,d₁₄ (GTP- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-16638

CB 3717 PDDF	Thymidylate Synthase	Metabolic Disease
CB 3717 is a potent inhibitor of human thymidylate synthetase, competitively binding with 5,10-methylenetetrahydrofolate (Ki = 4.9 X 10(-9) M). It also competitively inhibits human dihydrofolate reductase with dihydrofolate (Ki = 2.3 X 10(-8) M). In WI-L2 human lymphoblastoid cells, CB 3717 treatment led to a significant decrease in cellular dTTP levels and a notable increase in dUMP levels, indicating a disruption in nucleotide metabolism. The growth-inhibitory effect of CB 3717 was reversed by thymidine supplementation, demonstrating that thymidylate synthetase became rate-limiting in the presence of this compound. Delayed thymidine supplementation beyond 8 hours resulted in severe cytotoxicity, underscoring the critical timing of nucleotide rescue strategies in CB 3717-treated cells .

HY-W778990

2-Deoxyuridine-1,2,3,4,5-13C5	Isotope-Labeled Compounds Thymidylate Synthase Endogenous Metabolite	Infection
2-Deoxyuridine-1,2,3,4,5- ¹³C₅ is the ¹³C-labeled 2'-Deoxyuridine (HY-D0186). 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .

HY-159849

Cytidylyl-(3′,5′)-uridine	Nucleoside Antimetabolite/Analog	Metabolic Disease
Cytidylyl-(3′,5′)-uridine is a dinucleotide derivative that can be used to study nucleotide metabolism .

HY-W011012R

Adenosine 5'-monophosphate disodium (Standard)	Reference Standards Adenosine Receptor	Metabolic Disease
Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-W768246

Galactose 1-phosphate-13C6 potassium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Galactose 1-phosphate- ¹³C₆ potassium is the ¹³C-labeled Galactose 1-phosphate Potassium salt (HY-113143A). Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sugars.

HY-118793

Inosine oxime 6-Hydroxyadenosine	Endogenous Metabolite	Others
Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells .

HY-W011012S1

Adenosine 5'-monophosphate-d2 disodium	Isotope-Labeled Compounds	Others
Adenosine 5'-monophosphate-d₂ disodium is the deuterium labeled Adenosine 5'-monophosphate (HY-W011012). Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-135359R

RP 48497 (Standard)	Drug Metabolite Reference Standards	Neurological Disease
Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-B1162R

Sulisobenzone (Standard) Benzophenone-4 (Standard)	Biochemical Assay Reagents Reference Standards	Metabolic Disease
Sulisobenzone (Benzophenone-4) (Standard) is the analytical standard of Sulisobenzone (HY-B1162). This product is intended for research and analytical applications. Sulisobenzone is a benzophenone-type UV filter. Sulisobenzone can act as a endocrine disrupting compound. Sulisobenzone disrupts energy metabolism, nucleotide synthesis, oxidative stress response, and endocrine function. Sulisobenzone thyroid hormone biosynthesis and induces oxidative stress .

HY-106110

OP-2507	Prostaglandin Receptor	Metabolic Disease
OP-2507 is a prostacyclin analog. OP-2507 can increase brain glucose levels in mice, suppress the breakdown of energy metabolism under hypoxic conditions, and has a protective effect against changes in cyclic nucleotides in hypoxic brain tissue (specifically, an increase in cyclic AMP and a decrease in cyclic GMP). OP-2507 provides protective effects against brain hypoxia and edema .

HY-128738R

Thymidine-5'-monophosphate disodium salt (Standard) TMP disodium salt (Standard)	Reference Standards Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Thymidine-5'-monophosphate (TMP) disodium salt (Standard) is the analytical standard of Thymidine-5'-monophosphate disodium salt (HY-128738). This product is intended for research and analytical applications. Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury.

HY-181100

DHFR-IN-26	Dihydrofolate reductase (DHFR) Bacterial	Infection
DHFR-IN-26 is an Escherichia coli dihydrofolate reductase (ecDHFR) inhibitor with an IC₅₀ of 0.75 nM. DHFR-IN-26 exerts broad-spectrum antibacterial activity. DHFR-IN-26 disrupts folate metabolism, nucleotide synthesis, and bacterial amino acid metabolic pathways. DHFR-IN-26 disrupts bacterial inner membranes, inhibited biofilm formation, and attenuated phage-related processes. DHFR-IN-26 shows lower toxicity to non-cancerous cells. DHFR-IN-26 can be used for the research of bacterial infections (including infections caused by methicillin-resistant Staphylococcus aureus, multidrug-resistant Escherichia coli, multidrug-resistant Pseudomonas aeruginosa, and lysogenic bacteria) .

HY-182356

MTHFD1/2-IN-1	Methylenetetrahydrofolate Dehydrogenase (MTHFD)	Cancer
MTHFD1/2-IN-1 is an orally active dual MTHFD1/MTHFD2 inhibitor, with IC₅₀ values of 0.26 μM and 0.031 μM against human MTHFD1 and MTHFD2, respectively. MTHFD1/2-IN-1 blocks one-carbon metabolism by inhibiting the dehydrogenase activity of MTHFD1 as well as the dehydrogenase and cyclohydrolase activities of MTHFD2, thereby disrupting nucleotide biosynthesis and redox homeostasis in cancer cells. MTHFD1/2-IN-1 exhibits favorable Caco-2 permeability and hepatic microsomal metabolic stability. MTHFD1/2-IN-1 shows significant anti-leukemic activity, which not only reduces the viability of various leukemia cells but also inhibits tumor growth of acute myeloid leukemia (AML) in mouse models .

HY-E71162

1,4-β-D-Xylan synthase	Biochemical Assay Reagents	Others
1,4-β-D-Xylan synthase (EC 2.4.2.24) belongs to the family of glycosyltransferases, specifically the pentosyltransferases. 1,4-β-D-Xylan synthase (EC 2.4.2.24) participates in starch and sucrose metabolism and nucleotide sugars metabolism.

HY-N18991

D-Mannitol 1-phosphate	Endogenous Metabolite Bacterial	Infection
D-Mannitol 1-phosphate is a non-nucleotide phosphate ester. D-Mannitol 1-phosphate is isolable from Lactobacillus arabinosus. D-Mannitol 1-phosphate is associated with active polyol metabolism in Lactobacillus arabinosus .

HY-181981

NTPDase/NPP1-IN-1	NTPDase Phosphodiesterase (PDE)	Cancer
NTPDase/NPP1-IN-1 is an ectonucleotidase (NTPDase) and nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitor, with IC₅₀ values of 0.28, 0.92, 0.82 and 0.73 μM against h-NTPDase1, h-NTPDase2, h-NTPDase3 and h-NPP1, respectively. NTPDase/NPP1-IN-1 is a membrane-interacting agent that localizes to the plasma membrane and interacts with cancer cells. NTPDase/NPP1-IN-1 can be used in the research of breast cancer .

HY-105111

P-536	Parasite Angiotensin-converting Enzyme (ACE) HSV DNA/RNA Synthesis	Cardiovascular Disease Metabolic Disease
P-536 is a ACE inhibitor that also inhibits herpes simplex virus HSV-1 thymidine kinase and Trypanosoma cruzi RNA polymerase. By inhibiting the renin-angiotensin system, downregulating the expression of AT1R and NOX4, and reducing oxidative stress (decreasing plasma hydrogen peroxide (H₂O₂) and 8-isoprostaglandin levels), P-536 effectively reduces systolic blood pressure and improves vascular reactivity. P-536 also inhibits the replication of DNA/RNA viruses such as HSV-1 by blocking nucleotide metabolism and nucleic acid synthesis, competitively inhibits RNA synthesis in Trypanosoma cruzi, and inhibits amastigote replication, thereby impeding its growth. P-536 is suitable for research on hypertension, insulin resistance, and Chagas disease .

Cat. No.	Product Name

HY-L234

Nucleotide Metabolite Compound Library

82 compounds

Nucleotide metabolism is central to cancer aggressiveness, underpinning uncontrolled proliferation, chemotherapy resistance, immune evasion, and metastasis. It is transcriptionally regulated by oncogenes (e.g., MYC) and tumor suppressors (e.g., pRb). Nucleotide imbalance and nucleoside degradation further regulate cell state transitions, especially following replication stress. Additionally, secretion of nucleotides/nucleosides into the tumor microenvironment modulates immune responses and influences treatment efficacy. Therefore, nucleotide metabolites have roles in disease response and indication in cancer research, and can be utilized to develop cancer-related mechanisms and drugs.

MCE can provide 82 metabolites produced by nucleotide metabolic pathways, which can be used for disease mechanism research and drug research.

HY-L227

Amino Acid Metabolite Compound Library

198 compounds

Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism.

MCE can provide 198 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases

HY-L044

Nucleotide Compound Library

572 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 572 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

HY-L064

Glutamine Metabolism Compound Library

1,690 compounds

Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

MCE owns a unique collection of 1,690 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Cat. No.	Product Name	Type

HY-114364

UDP-Galactose disodium 4 Publications Verification	Biochemical Assay Reagents
UDP-Galactose disodium is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose disodium is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose disodium can be used to study cell signal transduction and substance metabolism .

HY-W011012

Adenosine 5'-monophosphate disodium

15+ Cited Publications

Biochemical Assay Reagents

Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-W011012R

Adenosine 5'-monophosphate disodium (Standard)

Biochemical Assay Reagents

Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W013046

Phosphoribosyl pyrophosphate pentasodium PRPP pentasodium	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP .

HY-N5134

5'-Guanylic acid 2 Publications Verification 5'-GMP; 5'-guanosine monophosphate	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite iGluR
5'-Guanylic acid is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid also causes neuronal cell death at high concentrations .

HY-114364

UDP-Galactose disodium 4 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite P2Y Receptor
UDP-Galactose disodium is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose disodium is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose disodium can be used to study cell signal transduction and substance metabolism .

HY-D0186

2'-Deoxyuridine 3 Publications Verification	Infection Natural Products Immune System Disorder Microorganisms Classification of Application Fields Disease markers Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Thymidylate Synthase
2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .

HY-W010970

5'-Guanylic acid disodium salt 2 Publications Verification 5'-GMP disodium salt; 5'-guanosine monophosphate disodium salt	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite iGluR
5'-Guanylic acid disodium salt is the disodium salt form of 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid disodium salt is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid disodium salt regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid disodium salt is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid disodium salt also causes neuronal cell death at high concentrations .

HY-128738

Thymidine-5'-monophosphate disodium salt 1 Publications Verification TMP disodium salt	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury .

HY-113225

Guanosine triphosphate GTP	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis
Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-150524

UDP-Galactose	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite P2Y Receptor
UDP-Galactose is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose can be used to study cell signal transduction and substance metabolism .

HY-D0186R

2'-Deoxyuridine (Standard)	Structural Classification Natural Products Immune System Disorder Microorganisms Disease markers Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Thymidylate Synthase
2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine. This product is intended for research and analytical applications. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) . In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine . Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min . In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain . 2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model .

HY-134529

D-Ribofuranose1-dihydrogenphosphate Ribose 1-phosphate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
D-Ribofuranose 1-dihydrogenphosphate (Ribose 1-phosphate) dicyclohexanamine is a pentose phosphate and serves as a key intermediate metabolite in the salvage synthesis pathway of purine and pyrimidine nucleotides. In nucleotide salvage synthesis, D-Ribofuranose 1-dihydrogenphosphate dicyclohexanamine directly "transfers" the ribosyl group from purine nucleosides to pyrimidine bases, acting as a hub molecule linking nucleoside/base metabolism with pentose phosphate metabolism .

HY-118793

Inosine oxime 6-Hydroxyadenosine	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells .

HY-128738R

Thymidine-5'-monophosphate disodium salt (Standard) TMP disodium salt (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite	Reference Standards Endogenous Metabolite DNA/RNA Synthesis
Thymidine-5'-monophosphate (TMP) disodium salt (Standard) is the analytical standard of Thymidine-5'-monophosphate disodium salt (HY-128738). This product is intended for research and analytical applications. Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury.

HY-N18991

D-Mannitol 1-phosphate	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite Bacterial
D-Mannitol 1-phosphate is a non-nucleotide phosphate ester. D-Mannitol 1-phosphate is isolable from Lactobacillus arabinosus. D-Mannitol 1-phosphate is associated with active polyol metabolism in Lactobacillus arabinosus .

Cat. No.	Product Name	Chemical Structure

HY-113225S2

Guanosine triphosphate-13C dilithium

Guanosine triphosphate- ¹³C (GTP- ¹³C) dilithium is ¹³C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S3

Guanosine triphosphate-15N5 dilithium

Guanosine triphosphate- ¹⁵N₅ (GTP- ¹⁵N₅) dilithium is ¹⁵N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S5

Guanosine triphosphate-13C10 dilithium

Guanosine triphosphate- ¹³C₁₀ (GTP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113143AS

Galactose 1-phosphate-13C potassium
Galactose 1-phosphate- ¹³C (potassium) is the ¹³C labeled Galactose 1-phosphate Potassium salt. Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sug .

HY-113143AS1

Galactose 1-phosphate-13C-1 potassium
Galactose 1-phosphate- ¹³C-1 (potassium) is the ¹³C labeled Galactose 1-phosphate Potassium salt. Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sug .

HY-114364S

UDP-α-D-Galactose-13C disodium

UDP-α-D-Galactose- ¹³C disodium is the ¹³C labeled UDP-α-D-Galactose disodium. UDP-Galactose disodium is a monosaccharide and a key glycosyl donor molecule in cells that participates in nucleotide sugar metabolism. UDP-Galactose disodium is the natural agonist of the P2Y₁₄ receptor coupled to G_i proteins in the immune system (IC₅₀= 0.67 μM, hP2Y₁₄). UDP-Galactose disodium can be used to study cell signal transduction and substance metabolism .

HY-W011012S

Adenosine 5'-monophosphate-13C disodium

Adenosine 5'-monophosphate- ¹³C (disodium) is a ¹³C-labeled Adenosine 5'-monophosphate (HY-W011012). Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

HY-113225S1

Guanosine triphosphate-13C10,15N5 tetraammonium solution (100 mM)

Guanosine triphosphate- ¹³C₁₀, ¹⁵N₅ tetraammonium is the ¹³C and ¹⁵N labeled Guanosine triphosphate tetraammonium. Guanosine triphosphate tetraammonium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate tetraammonium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate tetraammonium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate tetraammonium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate tetraammonium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S4

Guanosine triphosphate-15N5,d14 dilithium

Guanosine triphosphate- ¹⁵N₅,d₁₄ (GTP- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-W778990

2-Deoxyuridine-1,2,3,4,5-13C5

2-Deoxyuridine-1,2,3,4,5- ¹³C₅ is the ¹³C-labeled 2'-Deoxyuridine (HY-D0186). 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .

HY-W768246

Galactose 1-phosphate-13C6 potassium
Galactose 1-phosphate- ¹³C₆ potassium is the ¹³C-labeled Galactose 1-phosphate Potassium salt (HY-113143A). Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sugars.

HY-W011012S1

Adenosine 5'-monophosphate-d2 disodium

Adenosine 5'-monophosphate-d₂ disodium is the deuterium labeled Adenosine 5'-monophosphate (HY-W011012). Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes .

Cat. No.	Product Name		Classification

HY-147309

16-Azidohexadecanoic acid		Azide
16-Azidohexadecanoic acid, a synthetic fatty acid, can be used as a modification marker for nucleotides and a molecular probe for fatty acid metabolism . 16-Azidohexadecanoic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-W010970

5'-Guanylic acid disodium salt 2 Publications Verification 5'-GMP disodium salt; 5'-guanosine monophosphate disodium salt		Nucleotide Analogs
5'-Guanylic acid disodium salt is the disodium salt form of 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid disodium salt is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid disodium salt regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid disodium salt is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid disodium salt also causes neuronal cell death at high concentrations .

HY-128738

Thymidine-5'-monophosphate disodium salt 1 Publications Verification TMP disodium salt		Nucleotide Analogs
Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury .

HY-113225

Guanosine triphosphate GTP		Nucleotide Analogs
Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-159849

Cytidylyl-(3′,5′)-uridine		Nucleoside Analogs Uridine
Cytidylyl-(3′,5′)-uridine is a dinucleotide derivative that can be used to study nucleotide metabolism .

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