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oral epidermoid carcinoma

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cholinesterase (ChE) (1) Drug Derivative (2) Fungal (1) p38 MAPK (1) Parasite (1)
By Research Areas:	Cancer (9) Infection (2) Inflammation/Immunology (1) Neurological Disease (2)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8420

Thalifoline	Fungal	Infection Cancer
Thalifoline is an isoquinoline alkaloid. Thalifoline exerts cytotoxic effects on cancer cells. Thalifoline inhibits the growth of Fusarium oxysporum f. sp. lycopersici. Thalifoline can be used in research related to lung adenocarcinoma, colon cancer, oral epidermoid carcinoma, and fungal infections .

HY-W278867

trans-3,5-Dimethoxystilbene trans-Pinosylvin dimethyl ether	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
trans-3,5-Dimethoxystilbene (trans-Pinosylvin dimethyl ether) is a natural stilbenoid metabolite. trans-3,5-Dimethoxystilbene acts as an acetylcholinesterase inhibitor with a IC₅₀ of 9 μM against Electrophorus electricus acetylcholinesterase. trans-3,5-Dimethoxystilbene binds to acetylcholinesterase and blocks acetylcholine hydrolysis, thereby increasing acetylcholine levels in the cholinergic synaptic cleft. trans-3,5-Dimethoxystilbene can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

HY-N1261

Scutebarbatine B	Others	Cancer
Scutebarbatine B shows significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC₅₀ values in the range 3.5-8.1 mM ^[1]<

HY-N15199

Schisanlactone A	Others	Cancer
Schisanlactone A is a natural triterpenoid compound. Schisanlactone A has moderate cytotoxicity, with its IC₅₀ value being 63.3 μM against KB cells. Schisanlactone A does not possess antibacterial or tyrosinase inhibitory activities. Schisanlactone A can be used for the study of oral epidermoid carcinoma .

HY-10320G

Doramapimod (GMP) BIRB 796 (GMP)	p38 MAPK	Cancer
Doramapimod GMP (BIRB 796 GMP) is an orally active inhibitor for p38 MAPK, with IC₅₀s of 38, 65, 200 and 520 nM, for p38α, p38β, p38γ, p38δ. Doramapimod exhibits cytotoxicity and antitumor activity against multiple myeloma, synergizes with multidrug resistance protein 1 (ABCB1) and aurora kinase inhibitor VX680, promoting their antitumor efficacy against oral epidermoid carcinoma and cervical cancer. Doramapimod also exhibits anti-inflammatory activity .

HY-N18150

12-O-Methylvolkensin	Others	Cancer
12-O-Methylvolkensin is a limonoid found in the fruits of Melia toosendan Sieb. et Zucc. 12-O-Methylvolkensin shows cytotoxicity against cancer cells. 12-O-Methylvolkensin can be used for the research of cancer, such as human oral epidermoid carcinoma .

HY-N19845

2′,7-Diacetyltaxol	Drug Derivative	Neurological Disease Cancer
2′,7-Diacetyltaxol (Compound 3) is an acetylated derivative of Paclitaxel (HY-B0015) and a cytotoxic agent. 2′,7-Diacetyltaxol is isolated from the acetylated fraction of Taxus brevifolia Nutt. 2′,7-Diacetyltaxol exhibits anticancer activity against oral epidermoid carcinoma. 2′,7-Diacetyltaxol is applicable to the research of neurological diseases .

HY-N18294

(R,R)-Polysphorin	Parasite	Infection Cancer
(R,R)-Polysphorin is a neolignan antimalarial agent that is isolated from the dried leaves and stems of Rhaphidophora decursiva. (R,R)-Polysphorin inhibits the growth of chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum clones in vitro by mediating free radical damage to key cellular components via conjugated double bonds. (R,R)-Polysphorin also exhibits cytotoxicity against human oral epidermoid carcinoma cells .

HY-N8013

5-O,8-Dimethylophiopogonanone B	Others	Cancer
5-O,8-Dimethylophiopogonanone B is a homoisoflavanone found in the tuberous roots of Ophiopogon japonicus. 5-O,8-Dimethylophiopogonanone B shows cytotoxicity against cancer cells. 5-O,8-Dimethylophiopogonanone B can be used for the research of cancer, such as breast cancer .

HY-N19853

Mangiferonic acid	Drug Derivative	Cancer
Mangiferonic acid is a triterpenoid found in the stems of Vatica diospyroides. Mangiferonic acid can be used for cancer research .

Thalifoline	Infection Alkaloids Structural Classification Monophenols Classification of Application Fields Phenols Plants Isoquinoline Alkaloids Menispermaceae Disease Research Fields Menispermum dauricum Source Classification	Fungal
Thalifoline is an isoquinoline alkaloid. Thalifoline exerts cytotoxic effects on cancer cells. Thalifoline inhibits the growth of Fusarium oxysporum f. sp. lycopersici. Thalifoline can be used in research related to lung adenocarcinoma, colon cancer, oral epidermoid carcinoma, and fungal infections .

trans-3,5-Dimethoxystilbene trans-Pinosylvin dimethyl ether	Structural Classification Stilbenes Classification of Application Fields Leguminosae Plants Inflammation/Immunology Disease Research Fields Astragalus membranaceus (Fisch.) Bunge Source Classification	Cholinesterase (ChE)
trans-3,5-Dimethoxystilbene (trans-Pinosylvin dimethyl ether) is a natural stilbenoid metabolite. trans-3,5-Dimethoxystilbene acts as an acetylcholinesterase inhibitor with a IC₅₀ of 9 μM against Electrophorus electricus acetylcholinesterase. trans-3,5-Dimethoxystilbene binds to acetylcholinesterase and blocks acetylcholine hydrolysis, thereby increasing acetylcholine levels in the cholinergic synaptic cleft. trans-3,5-Dimethoxystilbene can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

Scutebarbatine B	Alkaloids Classification of Application Fields Labiatae Derris robusta Pyridine Alkaloids Plants Disease Research Fields Cancer Source Classification	Others
Scutebarbatine B shows significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, with IC₅₀ values in the range 3.5-8.1 mM ^[1]<

Schisanlactone A	Triterpenes Structural Classification Terpenoids Cardiacglycosides Schisandra henryi subsp. yunnanensis (A. C. Smith) R. M. K. Saunders Plants Schisandraceae Steroids Source Classification	Others
Schisanlactone A is a natural triterpenoid compound. Schisanlactone A has moderate cytotoxicity, with its IC₅₀ value being 63.3 μM against KB cells. Schisanlactone A does not possess antibacterial or tyrosinase inhibitory activities. Schisanlactone A can be used for the study of oral epidermoid carcinoma .

12-O-Methylvolkensin	Structural Classification Natural Products Melia azedarach Linn. Plants Meliaceae Source Classification	Others
12-O-Methylvolkensin is a limonoid found in the fruits of Melia toosendan Sieb. et Zucc. 12-O-Methylvolkensin shows cytotoxicity against cancer cells. 12-O-Methylvolkensin can be used for the research of cancer, such as human oral epidermoid carcinoma .

2′,7-Diacetyltaxol	Structural Classification Natural Products Taxaceae Plants Taxus brevifolia Nutt. Source Classification	Drug Derivative
2′,7-Diacetyltaxol (Compound 3) is an acetylated derivative of Paclitaxel (HY-B0015) and a cytotoxic agent. 2′,7-Diacetyltaxol is isolated from the acetylated fraction of Taxus brevifolia Nutt. 2′,7-Diacetyltaxol exhibits anticancer activity against oral epidermoid carcinoma. 2′,7-Diacetyltaxol is applicable to the research of neurological diseases .

(R,R)-Polysphorin	Structural Classification Araceae Ketones, Aldehydes, Acids Rhaphidophora decursiva (Roxb.) Schott Plants Source Classification	Parasite
(R,R)-Polysphorin is a neolignan antimalarial agent that is isolated from the dried leaves and stems of Rhaphidophora decursiva. (R,R)-Polysphorin inhibits the growth of chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum clones in vitro by mediating free radical damage to key cellular components via conjugated double bonds. (R,R)-Polysphorin also exhibits cytotoxicity against human oral epidermoid carcinoma cells .

5-O,8-Dimethylophiopogonanone B	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Monophenols Liliaceae Phenols Plants Source Classification	Others
5-O,8-Dimethylophiopogonanone B is a homoisoflavanone found in the tuberous roots of Ophiopogon japonicus. 5-O,8-Dimethylophiopogonanone B shows cytotoxicity against cancer cells. 5-O,8-Dimethylophiopogonanone B can be used for the research of cancer, such as breast cancer .

Mangiferonic acid	Triterpenes Structural Classification Terpenoids Vatica diospyroides Symington Plants Dipterocarpaceae Source Classification	Drug Derivative
Mangiferonic acid is a triterpenoid found in the stems of Vatica diospyroides. Mangiferonic acid can be used for cancer research .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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oral epidermoid carcinoma

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