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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
outgrowth-promoting
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "outgrowth-promoting" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-P700138AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDK; Midgestation And Kidney Protein; Prev. NEGF2; ARAP; MK; Neurite outgrowth-promoting Protein; Neurite outgrowth-promoting Factor 2; Retinoic Acid Inducible Factor; Neurite Growth-promoting Factor 2; Mutant Truncated Midkine B; Amphiregulin-Associated
Species:
Human
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-P71213
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTN; HBNF-1; Prev. NEGF1; HBBM; HBNF; Pleiotrophin (Heparin Binding Growth Factor 8, Neurite Growth-promoting Factor 1); HBGF8; Heparin-Binding Neurite outgrowth promoting Factor; Heparin-Binding Neurite outgrowth-promoting Factor 1; Heparin-Binding Neuri
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Synonyms: SR57746A; SR57746 hydrochloride
Target:
5-HT Receptor Dopamine Receptor Trk Receptor PKC ERK Akt JNK
Research Areas:
Xaliproden (SR57746) hydrochloride (SR57746A) is an orally active, highly selective 5-HT1A receptor agonist. Xaliproden hydrochloride activates pertussis toxin-sensitive G protein-coupled signaling cascades, as well as the PKC, ERK1/ERK2, Akt and p21 Ras/MEK-1 pathways. Xaliproden hydrochloride also downregulates the JNK/p66/c-Jun signaling pathway, induces phosphorylation of the shc adaptor protein, regulates extracellular dopamine and 5-HT levels, and induces [ 35S]GTPγS labeling in rat brain structures rich in 5-HT1A receptors. Xaliproden hydrochloride exerts neurotrophic, neuroprotective, renoprotective, anti-inflammatory, anti-apoptotic, anti-fibrotic and analgesic effects. Xaliproden hydrochloride also enhances NGF-induced neurite outgrowth, promotes motor neuron survival, attenuates renal tubular injury and inhibits chemotherapy-induced mechanical allodynia, without activating or altering NGF-induced TrkA receptor activation. Xaliproden hydrochloride can be used in the research of motor neuron disease, diabetic nephropathy, chemotherapy-induced peripheral neuropathy, amyotrophic lateral sclerosis, Alzheimer's disease, acute tonic nociceptive pain, inflammatory pain, depression and anxiety .
1
1 Cited Publications
Cat. No.: HY-P73295
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDK; Midgestation And Kidney Protein; Prev. NEGF2; ARAP; MK; Neurite outgrowth-promoting Protein; Neurite outgrowth-promoting Factor 2; Retinoic Acid Inducible Factor; Neurite Growth-promoting Factor 2; Mutant Truncated Midkine B; Amphiregulin-Associated
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P700223AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDK; Midgestation And Kidney Protein; Prev. NEGF2; ARAP; MK; Neurite outgrowth-promoting Protein; Neurite outgrowth-promoting Factor 2; Retinoic Acid Inducible Factor; Neurite Growth-promoting Factor 2; Mutant Truncated Midkine B; Amphiregulin-Associated
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P700791
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDK; Midgestation And Kidney Protein; Prev. NEGF2; ARAP; MK; Neurite outgrowth-promoting Protein; Neurite outgrowth-promoting Factor 2; Retinoic Acid Inducible Factor; Neurite Growth-promoting Factor 2; Mutant Truncated Midkine B; Amphiregulin-Associated
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P79419
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDK; Midgestation And Kidney Protein; Prev. NEGF2; ARAP; MK; Neurite outgrowth-promoting Protein; Neurite outgrowth-promoting Factor 2; Retinoic Acid Inducible Factor; Neurite Growth-promoting Factor 2; Mutant Truncated Midkine B; Amphiregulin-Associated Protein; MK1; Midkine; FLJ27379
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P701025
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDK; Midgestation And Kidney Protein; Prev. NEGF2; ARAP; MK; Neurite outgrowth-promoting Protein; Neurite outgrowth-promoting Factor 2; Retinoic Acid Inducible Factor; Neurite Growth-promoting Factor 2; Mutant Truncated Midkine B; Amphiregulin-Associated
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P701024
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MDK; Midgestation And Kidney Protein; Prev. NEGF2; ARAP; MK; Neurite outgrowth-promoting Protein; Neurite outgrowth-promoting Factor 2; Retinoic Acid Inducible Factor; Neurite Growth-promoting Factor 2; Mutant Truncated Midkine B; Amphiregulin-Associated
Species:
Human
Source:
E. coli
Cat. No.: HY-P71907
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTN; HBNF-1; Prev. NEGF1; HBBM; HBNF; Pleiotrophin (Heparin Binding Growth Factor 8, Neurite Growth-promoting Factor 1); HBGF8; Heparin-Binding Neurite outgrowth promoting Factor; Heparin-Binding Neurite outgrowth-promoting Factor 1; Heparin-Binding Neuri
Species:
Human
Source:
E. coli
Cat. No.: HY-P78342
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PTN; HBNF-1; Prev. NEGF1; HBBM; HBNF; Pleiotrophin (Heparin Binding Growth Factor 8, Neurite Growth-promoting Factor 1); HBGF8; Heparin-Binding Neurite outgrowth promoting Factor; Heparin-Binding Neurite outgrowth-promoting Factor 1; Heparin-Binding Neuri
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P700145AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTN; HBNF-1; Prev. NEGF1; HBBM; HBNF; Pleiotrophin (Heparin Binding Growth Factor 8, Neurite Growth-promoting Factor 1); HBGF8; Heparin-Binding Neurite outgrowth promoting Factor; Heparin-Binding Neurite outgrowth-promoting Factor 1; Heparin-Binding Neuri
Species:
Human
Source:
E. coli
Cat. No.: HY-119820
CAS No.: 135354-02-8
Synonyms: SR57746A free base
Target:
Akt Dopamine Receptor Trk Receptor 5-HT Receptor PKC JNK ERK
Research Areas:
Xaliproden (SR57746) free base is an orally active, highly selective 5-HT1A receptor agonist. Xaliproden free base activates pertussis toxin-sensitive G protein-coupled signaling cascades, as well as the PKC, ERK1/ERK2, Akt and p21 Ras/MEK-1 pathways. Xaliproden free base also downregulates the JNK/p66/c-Jun signaling pathway, induces phosphorylation of the shc adaptor protein, regulates extracellular dopamine and 5-HT levels, and induces [ 35S]GTPγS labeling in rat brain structures rich in 5-HT1A receptors. Xaliproden free base exerts neurotrophic, neuroprotective, renoprotective, anti-inflammatory, anti-apoptotic, anti-fibrotic and analgesic effects. Xaliproden free base also enhances NGF-induced neurite outgrowth, promotes motor neuron survival, attenuates renal tubular injury and inhibits chemotherapy-induced mechanical allodynia, without activating or altering NGF-induced TrkA receptor activation. Xaliproden free base can be used in the research of motor neuron disease, diabetic nephropathy, chemotherapy-induced peripheral neuropathy, amyotrophic lateral sclerosis, Alzheimer's disease, acute tonic nociceptive pain, inflammatory pain, depression and anxiety .
Cat. No.: HY-P82028
Synonyms: PTN; HBNF1; NEGF1; Pleiotrophin; PTN; Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; Osteoblast-specific factor 1; OSF-1
Cat. No.: HY-P82028A
Synonyms: PTN; HBNF1; NEGF1; Pleiotrophin; PTN; Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; Osteoblast-specific factor 1; OSF-1
Cat. No.: HY-14604R
CAS No.: 90494-79-4
Synonyms: SR57746A (Standard); SR57746 hydrochloride (Standard)
Research Areas:
Xaliproden (hydrochloride) (Standard) is the analytical standard of Xaliproden (hydrochloride). This product is intended for research and analytical applications. Xaliproden (SR57746) hydrochloride (SR57746A) is an orally active, highly selective 5-HT1A receptor agonist. Xaliproden hydrochloride activates pertussis toxin-sensitive G protein-coupled signaling cascades, as well as the PKC, ERK1/ERK2, Akt and p21 Ras/MEK-1 pathways. Xaliproden hydrochloride also downregulates the JNK/p66/c-Jun signaling pathway, induces phosphorylation of the shc adaptor protein, regulates extracellular dopamine and 5-HT levels, and induces [ 35S]GTPγS labeling in rat brain structures rich in 5-HT1A receptors. Xaliproden hydrochloride exerts neurotrophic, neuroprotective, renoprotective, anti-inflammatory, anti-apoptotic, anti-fibrotic and analgesic effects. Xaliproden hydrochloride also enhances NGF-induced neurite outgrowth, promotes motor neuron survival, attenuates renal tubular injury and inhibits chemotherapy-induced mechanical allodynia, without activating or altering NGF-induced TrkA receptor activation. Xaliproden hydrochloride can be used in the research of motor neuron disease, diabetic nephropathy, chemotherapy-induced peripheral neuropathy, amyotrophic lateral sclerosis, Alzheimer's disease, acute tonic nociceptive pain, inflammatory pain, depression and anxiety .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
