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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
86 Results for "
p50
" in MedChemExpress (MCE) Product Catalog:
Products (86)
86 Results for "p50" in MCE Product Catalog:
35
Category:
Infection Acanthaceae Extract Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Disease Research Fields Inflammation/Immunology
Target:
16
Category:
Xanthones Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Liliaceae Extract Disease Research Fields Cancer
Target:
3
2
2 Cited Publications
Research Areas:
K284-6111 is a high-affinity and orally active CHI3L1 inhibitor, and inhibits CHI3L1 expression. K284-6111 inhibits ERK and NF-κB pathway. K284-6111 suppresses nuclear translocation of p50 and p65, and phosphorylation of IκB. K284-6111 improves memory dysfunction by alleviating amyloidogenesis and neuroinflammation, with the reduction of inflammatory proteins (eg: iNOS, COX-2, GFAP, and Iba-1). K284-6111 reduces atopic-like skin inflammation and inhibits LPS (HY-D1056) -induced liver injury. K284-6111 can be used for the study of Alzheimer's diseases and sepsis like hepatic injury .
2
2 Cited Publications
Cat. No.: HY-P701325
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: THBS1; THBS; Thrombospondin 1; Thrombospondin-1p180; TSP1; Thrombospondin-1; TSP; Glycoprotein G; THBS-1; Thrombospondin-p50; TSP-1; THBS1 Protein
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-N6046
CAS No.: 73981-34-7
1
1 Cited Publications
JS6 is a Bcl3 inhibitor. JS6 attenuates the binding of Bcl3 to NF-κB1 (p50), disrupts the binding of Bcl3 to NF-κB family proteins p50 and p52, and inhibits the NF-κB signaling pathway. JS6 is applicable to breast cancer-related research .
Target:
Target:
Cat. No.: HY-RS00964
Target:
Research Areas:
ARHGEF7 Human Pre-designed siRNA Set A contains three designed siRNAs for ARHGEF7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P10030
CAS No.: 1801379-22-5
Target:
Research Areas:
Cat. No.: HY-175397
Synonyms: DFHBI-thalidomide
Research Areas:
Dth (DFHBI-thalidomide) is an RNA aptamer-based PROTAC degrader. Dth can degrade a variety of endogenous proteins (such as mCherry, p50, p65 and E2F1) by replacing the 3′ module on the RNA scaffold with the RNA aptamer corresponding to the target protein. Dth upregulates IκB-α and Bax, and downregulates Bcl-2 and VEGF. Dth generates green fluorescence upon binding to the Broccoli RNA aptamer, enabling the tracing of RNA scaffolds. Dth can be used in cancer-related research .
Cat. No.: HY-RS18543
Target:
Research Areas:
Pold2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pold2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-149513
CAS No.: 2882916-73-4
EP12 is a c-Myc inhibitor. EP12 is a c-Myc G4 stabilizer. EP12 induces apoptosis and DNA damage in multiple myeloma cells. EP12 disrupts the nuclear translocation of P65/P50 by interfering with the NF-κB signaling pathway. EP12 inhibits multiple myeloma growth .
Cat. No.: HY-N0191S
Synonyms: Andrographis-d
Cat. No.: HY-183786
Target:
Research Areas:
Anticancer agent 327, a fluorescent Andrographolide (HY-N0191) derivative, is an NF-κB p50 inhibitor. Anticancer agent 327 covalently binds to the p50 subunit of NF-κB. Anticancer agent 327 reduces levels of multiple oncogenic p53 proteins via the autophagy/lysosome pathway. Anticancer agent 327 can be used for the research of pancreatic ductal adenocarcinoma (Ex/Em = 488/515 nm)[1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
