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Isoforms Recommended:	Caspase 3

Results for "

procaspase-3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (9) Autophagy (2) Bcl-2 Family (1) Caspase (15) ERK (1) HSV (1) Integrin (5) Isotope-Labeled Compounds (1) JNK (1) Mitochondrial Metabolism (1) NF-κB (1) p38 MAPK (1) PARP (2) Pyroptosis (1) Reference Standards (3) TNF Receptor (1)
By Research Areas:	Cancer (12) Infection (1) Inflammation/Immunology (10)

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Peptides

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Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12290

Arg-Gly-Asp-Ser Maximum Cited Publications 9 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-P1740

RGD peptide (GRGDNP) 5+ Cited Publications	Integrin Apoptosis Caspase	Inflammation/Immunology
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation ^[3].

HY-100472

ZYZ-488	Caspase	Cancer
ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3 .

HY-13523

PAC-1 5+ Cited Publications procaspase activating compound 1	Caspase Autophagy Apoptosis	Cancer
PAC-1 is a *procaspase-3* activator that induces apoptosis in cancer cells with an EC₅₀ of 2.08 μM.

HY-P1740A

RGD peptide (GRGDNP) TFA 5+ Cited Publications	Integrin Apoptosis	Inflammation/Immunology Cancer
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation ^[3].

HY-10131

Procaspase-3/6 activator 1	Caspase	Others
Procaspase-3/6 activator 1 (compound 1541) is a highly specific and robust activator of executioner *procaspases-3* and -6, with EC₅₀ values of 2.4 ± 0.2 and 2.8 ± 0.3 μM, respectively. Procaspase-3/6 activator 1 does not activate procaspases-1 or -7 .

HY-131688

2-Chlorohexadecanoic acid	PARP Caspase	Inflammation/Immunology
2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3 .

HY-W748509

Pipernonaline	Caspase Apoptosis	Cancer
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-113471

Perillic acid	Apoptosis HSV	Infection Inflammation/Immunology Cancer
Perillic acid is the metabolite of Perillyl alcohol (HY-N7000). Perillic acid induces lung cancer cell cycle arrest and apoptosis. Perillic acid shows anti-HSV-1 and immunomodulatory activities ^[3].

HY-179699

Procaspase-3 activator 1	Caspase Apoptosis	Cancer
Procaspase-3 activator 1 is a potent *procaspase-3* activator. Procaspase-3 activator directly activates procaspase-3 through zinc chelation, thereby inducing apoptosis and inhibiting cancer cell proliferation. Procaspase-3 activator 1 can be used for the research of non-small cell lung cancer (NSCLC) and melanoma .

HY-117614

WF-210	Caspase Apoptosis	Cancer
WF-210 is a potent *procaspase-3* activator with an EC₅₀ value of 0.95 μM. WF-210 induces Apoptosis. WF-210 has anti-tumor activity .

HY-13523S

PAC-1-d8 procaspase activating compound 1-d₈	Isotope-Labeled Compounds Apoptosis Caspase Autophagy	Cancer
PAC-1-d₈ (Procaspase activating compound 1-d₈) is the deuterium labeled PAC-1 (HY-13523). PAC-1 is a procaspase-3 activator that induces apoptosis in cancer cells with an EC₅₀ of 2.08 μM.

HY-N5033

17-Hydroxy sprengerinin C	Bcl-2 Family Caspase	Cancer
17-Hydroxy sprengerinin C (compound 10) is a glycoside compound isolated from rhizomes of Polygonatum sibiricum. 17-Hydroxy sprengerinin C possesses stronger anticancer activities. 17-Hydroxy sprengerinin C reduces the expression of Blc-2 and pro-caspase3 and increases the production of Bax .

HY-119420

Acetoxycycloheximide	Antibiotic Apoptosis Caspase JNK p38 MAPK TNF Receptor ERK NF-κB Mitochondrial Metabolism	Inflammation/Immunology Cancer
Acetoxycycloheximide is an antibiotic with antitumor activity. Acetoxycycloheximide a protein synthesis inhibitor. Acetoxycycloheximide significantly induces activation of *procaspase-3* and subsequent apoptosis mediated by the Cytochrome c from mitochondria via activation of JNK pathway. Acetoxycycloheximide triggers the downregulation of cell surface TNF-R1 via the activation of ERK and p38 MAPK, thereby preventing activation of the NF-κB signaling pathway by TNF-α. Acetoxycycloheximide is much more toxic to female rats than to males. Acetoxycycloheximide can be used for inflammatory and immune diseases and cancers research ^[3].

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .

HY-12290R

Arg-Gly-Asp-Ser (Standard) RGDS peptide (Standard); Fibronectin tetrapeptide (Standard)	Integrin Reference Standards	Inflammation/Immunology
Arg-Gly-Asp-Ser (Standard) is the analytical standard of Arg-Gly-Asp-Ser. This product is intended for research and analytical applications. Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-100472R

ZYZ-488 (Standard)	Caspase Reference Standards	Cancer
ZYZ-488 (Standard) is the analytical standard of ZYZ-488 (HY-100472). This product is intended for research and analytical applications. ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3 .

HY-131688R

2-Chlorohexadecanoic acid (Standard)	PARP Caspase Reference Standards	Inflammation/Immunology
Neomycin (sulfate) (Standard) is the analytical standard of Neomycin (sulfate). This product is intended for research and analytical applications. Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis .

HY-181168

Lb54	Caspase Pyroptosis	Inflammation/Immunology
Lb54 is a *caspase-3* and *caspase-7* activator with an EC₅₀ of 660.9 nM for human *procaspase-3. Lb54 activates caspase-3/7, which cleaves Gasdermin D (GSDMD)* at aspartic acid residue 87 to generate a p10 fragment, preventing formation of the pore-forming p30 fragment of GSDMD. Lb54 suppresses GSDMD-mediated pyroptosis through caspase-3/7 activation, thereby attenuating inflammatory responses and conferring protection against sepsis. Lb54 alleviates acute lung injury, and inhibited systemic inflammation by restraining the maturation of monocyte-derived dendritic cells. Lb54 can be used for the research of sepsis .

HY-10132

CASP3 activator 1	Caspase	Cancer
CASP3 activator 1 (compound 1541) Ais an activator of executioner procaspases 3, 6 and 7. CASP3 activator 1 can be used for the research of cancer, neoplastic diseases .

Cat. No.	Product Name	Target	Research Area

HY-12290

Arg-Gly-Asp-Ser Maximum Cited Publications 9 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-P1740

RGD peptide (GRGDNP) 5+ Cited Publications	Integrin Apoptosis Caspase	Inflammation/Immunology
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation ^[3].

HY-P1740A

RGD peptide (GRGDNP) TFA 5+ Cited Publications	Integrin Apoptosis	Inflammation/Immunology Cancer
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation ^[3].

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .

HY-12290R

Arg-Gly-Asp-Ser (Standard) RGDS peptide (Standard); Fibronectin tetrapeptide (Standard)	Integrin Reference Standards	Inflammation/Immunology
Arg-Gly-Asp-Ser (Standard) is the analytical standard of Arg-Gly-Asp-Ser. This product is intended for research and analytical applications. Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W748509

Pipernonaline	Piper longum Linn. Alkaloids Piperidine Alkaloids Piperaceae Plants Source Classification	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72874

	Caspase-3/CASP3 Protein, Human (His) Caspase-3; CASP-3; CPP-32; SCA-1; YAMA	Human	E. coli
	Caspase-3/CASP3 protein is critical in the execution of apoptosis, cleaving PARP1 and activating SREBP, caspase-6, -7 and -9, initiating the cascade leading to apoptosis. In addition to apoptosis, it regulates cell adhesion, promotes inflammation, inhibits AKT1 in oxidative stress, and modulates antiviral responses by cleaving proteins such as CGAS, IRF3, and MAVS. Caspase-3/CASP3 Protein, Human (His) is the recombinant human-derived Caspase-3/CASP3 protein, expressed by E. coli , with C-His labeled tag.

HY-P79267

	*Pro-Caspase-3/Pro-CASP3 Protein, Human (277a.a, His)* Caspase-3; CASP3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1; CPP32	Human	E. coli
	Pro-Caspase-3/Pro-CASP3 Protein, Human (277a.a, His) is the recombinant human-derived Caspase-3/CASP3, expressed by E. coli , with N-His labeled tag.

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HY-13523S

PAC-1-d8
PAC-1-d₈ (Procaspase activating compound 1-d₈) is the deuterium labeled PAC-1 (HY-13523). PAC-1 is a procaspase-3 activator that induces apoptosis in cancer cells with an EC₅₀ of 2.08 μM.

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procaspase-3

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