Procaspase-3 activator 1
Procaspase-3 activator 1 is a potent procaspase-3 activator. Procaspase-3 activator directly activates procaspase-3 through zinc chelation, thereby inducing apoptosis and inhibiting cancer cell proliferation. Procaspase-3 activator 1 can be used for the research of non-small cell lung cancer (NSCLC) and melanoma.
For research use only. We do not sell to patients.
- Formula: C23H28N2O5
- Molecular Weight:412.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Procaspase-3 |
Procaspase-3 activator 1 (compound K-15) (24 h) demonstrates potent antiproliferative activity against A549 and A375 cells with IC50s of 3.96 and 21.18 µM, while maintaining negligible cytotoxicity against BEAS-2B cells at 10 μM, indicating its selectivity[1].
Procaspase-3 activator 1 (50 μM, 0-180 min) can directly activate procaspase-3 into caspase-3, exhibiting superior activation activity compared to the positive control PAC-1 (HY-13523)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 412.48
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Formula C23H28N2O5
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SMILES
CCCCCCOC1=C(C=C(C=C1)/C=N/NC(/C=C/C2=CC(O)=C(C=C2)O)=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Procaspase-3 activator 1 Related Classifications
HY-179699 Related Classifications
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