2. Apoptosis
  3. Caspase Apoptosis
  4. Procaspase-3 activator 1

Procaspase-3 activator 1 is a potent procaspase-3 activator. Procaspase-3 activator directly activates procaspase-3 through zinc chelation, thereby inducing apoptosis and inhibiting cancer cell proliferation. Procaspase-3 activator 1 can be used for the research of non-small cell lung cancer (NSCLC) and melanoma.

For research use only. We do not sell to patients.

Procaspase-3 activator 1

Procaspase-3 activator 1 Chemical Structure

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Procaspase-3 activator 1 Related Antibodies

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Description

Procaspase-3 activator 1 is a potent procaspase-3 activator. Procaspase-3 activator directly activates procaspase-3 through zinc chelation, thereby inducing apoptosis and inhibiting cancer cell proliferation. Procaspase-3 activator 1 can be used for the research of non-small cell lung cancer (NSCLC) and melanoma[1].

IC50 & Target[1]

Procaspase-3

 

In Vitro

Procaspase-3 activator 1 (compound K-15) (24 h) demonstrates potent antiproliferative activity against A549 and A375 cells with IC50s of 3.96 and 21.18 µM, while maintaining negligible cytotoxicity against BEAS-2B cells at 10 μM, indicating its selectivity[1].
Procaspase-3 activator 1 (50 μM, 0-180 min) can directly activate procaspase-3 into caspase-3, exhibiting superior activation activity compared to the positive control PAC-1 (HY-13523)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Procaspase-3 activator 1 Related Antibodies
Molecular Weight

412.48

Formula

C23H28N2O5
SMILES

CCCCCCOC1=C(C=C(C=C1)/C=N/NC(/C=C/C2=CC(O)=C(C=C2)O)=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Procaspase-3 activator 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Procaspase-3 activator 1CaspaseApoptosisApoptosis inductionProcaspase-3 activatorPharmacophore modelingCaffeic acid derivativesIn silico ADMETTargeted therapyInhibitorinhibitorinhibit

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Procaspase-3 activator 1
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