Procaspase-3 activator 1
Procaspase-3 activator 1 is a potent procaspase-3 activator. Procaspase-3 activator directly activates procaspase-3 through zinc chelation, thereby inducing apoptosis and inhibiting cancer cell proliferation. Procaspase-3 activator 1 can be used for the research of non-small cell lung cancer (NSCLC) and melanoma.
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- Formule: C23H28N2O5
- Masse moléculaire:412.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
Procaspase-3 |
In Vitro
Procaspase-3 activator 1 (compound K-15) (24 h) demonstrates potent antiproliferative activity against A549 and A375 cells with IC50s of 3.96 and 21.18 µM, while maintaining negligible cytotoxicity against BEAS-2B cells at 10 μM, indicating its selectivity[1].
Procaspase-3 activator 1 (50 μM, 0-180 min) can directly activate procaspase-3 into caspase-3, exhibiting superior activation activity compared to the positive control PAC-1 (HY-13523)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Apoptosis Solutions
- MTT Cell Proliferation Assay
Chemical Information
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Masse moléculaire 412.48
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Formule C23H28N2O5
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SMILES
CCCCCCOC1=C(C=C(C=C1)/C=N/NC(/C=C/C2=CC(O)=C(C=C2)O)=O)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Procaspase-3 activator 1 Related Classifications
HY-179699 Related Classifications
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