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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
proteolytic cleavage
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "proteolytic cleavage" in MCE Product Catalog:
16
16 Publications Verification
Cat. No.: HY-16657
CAS No.: 163847-77-6
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TAPI-1 is a broad-spectrum MMP inhibitor and NF-κB p65 inhibitor that targets ADAM17/TACE, ADAM10 and other proteins. TAPI-1 reduces the proteolytic cleavage of membrane-bound TNF-α, decreases TNF-α levels, inhibits NF-κB pathway activation, and downregulates profibrotic markers. TAPI-1 reduces the proportion of proinflammatory immune cells, alleviates cardiac and airway fibrosis, and improves cardiac function after myocardial infarction. Meanwhile, TAPI-1 inhibits the viability, migration and invasion of esophageal squamous cell carcinoma cells, enhances the chemosensitivity of Cisplatin (HY-17394), induces apoptosis, and shows low toxicity to normal esophageal epithelial cells. TAPI-1 can be widely used in studies related to myocardial infarction-induced heart failure, severe traumatic tracheal stenosis, esophageal squamous cell carcinoma and other conditions .
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3 Cited Publications
Cat. No.: HY-P1036
CAS No.: 206645-99-0
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3 Cited Publications
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3 Cited Publications
Cat. No.: HY-P1036A
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Cat. No.: HY-P0308
CAS No.: 103213-49-6
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ARI-3099 is an oral fibroblast activation protein (FAP) inhibitor. ARI-3099 specifically inhibits the proteolytic activity of FAP and blocks the cleavage of human FGF-21 between residues P171 and S172. ARI-3099 extends the half-life of circulating human FGF-21 in mice. ARI-3099 can be used in the research of type 2 diabetes and metabolic disorders .
Cat. No.: HY-P99626
CAS No.: 1643672-70-1
Synonyms: LY 3015014
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Cat. No.: HY-15211
CAS No.: 623165-93-5
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MRK 003 is an orally active γ-secretase inhibitor. MRK 003 targets the Notch signaling pathway by blocking the proteolytic cleavage of Notch receptors. MRK 003 inhibits tumor cell proliferation, induces apoptosis, downregulates anti-apoptotic proteins, upregulates phosphorylated Akt, suppresses angiogenesis, and overcomes microenvironment-mediated proliferative protection. MRK 003 can be used in research related to lung cancer, multiple myeloma, non-Hodgkin's lymphoma, pancreatic ductal adenocarcinoma, glioblastoma, and breast cancer .
Cat. No.: HY-P11189
CAS No.: 511511-06-1
Cat. No.: HY-P3234
CAS No.: 191338-87-1
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Cat. No.: HY-P5371
CAS No.: 145229-90-9
Cat. No.: HY-P10922
CAS No.: 1246741-19-4
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Cat. No.: HY-E71364
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Pepsin (USP) is a proteolytic enzyme. Pepsin (USP) catalyzes cleavage of peptide bonds in proteins and synthetic peptides. Pepsin (USP) dissolves protein nutrients, cleaves proteins into peptones, produces large polypeptides, smaller peptides, and free amino acids, affects amino acid release rates and protein allergenicity. Pepsin (USP) can be used for biochemical research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
