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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
64 Results for "
pv
" in MedChemExpress (MCE) Product Catalog:
Products (64)
64 Results for "pv" in MCE Product Catalog:
2
Target:
Research Areas:
PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768)-induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis .
2
2 Cited Publications
Cat. No.: HY-125864B
CAS No.: 9001-32-5
Research Areas:
Murine Fibrinogen is a native fibrinogen derived from mouse plasma. Murine Fibrinogen acts as a cerebrovascular permeability enhancer. Murine Fibrinogen activates matrix metalloproteinase-9 (MMP-9), downregulates the expression of vascular endothelial cadherin (VE-cadherin), and upregulates the expression of plasmalemmal vesicle-associated protein-1 (PV-1). Murine Fibrinogen increases macromolecular leakage from pial veins, thereby disrupting the microvascular integrity of cerebral blood vessels. Murine Fibrinogen can be used in studies related to cerebrovascular dysfunction .
1
1 Cited Publications
Cat. No.: HY-P700879
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: PLVAP; Fenestrated-Endothelial Linked Structure Protein; pv-1 Protein; Plasmalemma Vesicle Associated Protein; Fenestrated Endothelial-Linked Structure Protein; pv-1; Plasmalemma Vesicle-Associated Protein; FELS; Plasmalemma Vesicle Protein 1; pv1; DIAR10
Species:
Human
Source:
HEK293
Synonyms: STK-001 sodium
Target:
Research Areas:
Zorevunersen sodium is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen sodium increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen sodium restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen sodium can be used for research on Dravet syndrome .
Cat. No.: HY-130323
CAS No.: 67597-26-6
13-HPOT is a linolenic acid hydroperoxide and an antibacterial agent. 13-HPOT interacts with lipid representatives of bacterial inner membranes. 13-HPOT exerts dose-dependent in vitro antibacterial activity against Pectobacterium carotovorum, Pseudomonas syringae pv. syringae DC3000, and Xanthomonas translucens pv. translucens .
Cat. No.: HY-148410
CAS No.: 2415330-04-8
Synonyms: STK-001
Target:
Research Areas:
Zorevunersen is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen can be used for research on Dravet syndrome .
Cat. No.: HY-N14257
CAS No.: 108868-95-7
Category:
Cat. No.: HY-P990803
Target:
Research Areas:
Cat. No.: HY-W008864
CAS No.: 6291-42-5
Synonyms: β-Octaacetyllactose
Cat. No.: HY-118401
CAS No.: 81845-40-1
Cat. No.: HY-N15314
CAS No.: 212115-96-3
Category:
Cat. No.: HY-164523
CAS No.: 1093793-11-3
Target:
Research Areas:
PV1162 is a selective Chk2 inhibitor with an IC50 of 0.29 nM. PV1162 inhibits ATP binding to Chk2 by targeting the gatekeeper-dependent hydrophobic pocket, which is specific to Chk2 and located behind the ATP-binding site (adenine-binding region), thereby inhibiting the phosphorylation activity of Chk2. PV1162 holds potential application value in the field of cancer therapy .
Cat. No.: HY-155644
CAS No.: 2921602-31-3
Research Areas:
ROS inducer 1 (compound I29) is a fungicide, with EC50 against Xanthomonas axonopodis pv. citri (Xac), Xanthomonas oryzae pv. oryzae (Xoo), and Pseudomonas syringae pv. actinidiae (Psa) of 5.73, 6.62 and 9.05 μg/mL. ROS inducer 1 can effectively induce the production of ROS in Xanthomonas cells and inhibit rice bacterial blight. ROS inducer 1 has the potential to study bacterial infection in crops .
Category:
Target:
2,2',4'-Trichloroacetophenone (Compound 3) is an α-haloacetophenone analogue. 2,2',4'-Trichloroacetophenone exhibits good antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac) with EC50 values of 0.54 and 2.02 mg/L, respectively. 2,2',4'-Trichloroacetophenone can be used for antibacteria study .
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AN-12-H5, an antienterovirus compound, targets the replication processes of PV and enterovirus 71 (EV71) .
Cat. No.: HY-P10974
Target:
Research Areas:
Cat. No.: HY-178936
CAS No.: 3094174-82-7
Research Areas:
JAK2-IN-15 is an orally active, potent, selective JAK2 inhibitor (IC50 = 1.17 nM). JAK2-IN-15 can inhibit the AK2-STAT signaling pathway. JAK2-IN-15 significantly improves key pathological indicators such as hematocrit and splenomegaly in an Epoetin beta (HY-114134) (rhEPO)-induced mouse model. JAK2-IN-15 can be used for the study of Polycythemia Vera (PV) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
