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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
300 Results for "
randomized crossover trial
" in MedChemExpress (MCE) Product Catalog:
Products (300)
300 Results for "randomized crossover trial" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: Guanidinium chloride; Aminoformamidine hydrochloride
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TIC10 isomer is the isomer of TIC10. TIC10 isomer does not possess the reported biological activity of inducing TRIAL expression.
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1
1 Cited Publications
Cat. No.: HY-W105970
CAS No.: 7758-16-9
Synonyms: Disodium pyrophosphate; Sodium acid pyrophosphate; SAPP
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1 Cited Publications
Cat. No.: HY-D1668
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1 Cited Publications
Cat. No.: HY-P10776
CAS No.: 901117-08-6
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Cat. No.: HY-171135
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Cetuximab MMAE is an antibody-drug conjugate (ADC) targeting EGFR, formed by the random conjugation of the Cetuximab (HY-P9905) antibody and VcMMAE (HY-15575) via reduced interchain cysteines. Cetuximab MMAE binds to EGFR, blocks ligand interactions, inhibits downstream signal transduction, mediates receptor internalization, and delivers MMAE to induce G2/M phase cell cycle arrest, inhibit microtubule polymerization, interfere with mitosis, and exert radiosensitizing effects. Cetuximab MMAE limits the toxicity of free MMAE to EGFR-expressing cells and circumvents EGFR resistance mechanisms. Cetuximab MMAE is applicable to research related to EGFR + tumors .
Cat. No.: HY-P5423
CAS No.: 107658-43-5
Cat. No.: HY-P991628
Synonyms: PF-08634404
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Cat. No.: HY-D1725
Cat. No.: HY-171689
CAS No.: 2760250-80-2
Synonyms: AZD 8205; P-Sam
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Puxitatug samrotecan (AZD 8205) is an antibody-drug conjugate (ADC) targeting B7-H4, formed by the random conjugation of the Puxitatug (HY-P990059) antibody and AZ14170133 (HY-145399) via interchain cysteine reduction. Puxitatug samrotecan binds to B7-H4 to deliver the payload to B7-H4-expressing cells, inhibits topoisomerase I, and induces cytotoxicity in cancer cells and xenograft models. Puxitatug samrotecan can be used in studies of B7-H4-expressing tumors .
Cat. No.: HY-E70110
CAS No.: 37288-54-3
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Endo-1,4-β-mannanase is an important catalyst that randomly cleaves the β-1,4-linkages in the main chain of mannan, releasing short-chain β-1,4-mannan and mannose. The catalytic activity of Endo-1,4-β-mannanase toward locust bean gum is enhanced by Mn 2+, Co 2+, Ca 2+, Ba 2+, Triton X-100, sodium azide and N-ethylmaleimide, completely inhibited by Hg 2+ and N-bromosuccinimide, and partially inhibited by EDTA and Cu 2+. Endo-1,4-β-mannanase can be used in studies related to plant hemicellulose degradation, biomass saccharification, elimination of anti-nutritional factors in feed, and manno-oligosaccharide prebiotics .
Cat. No.: HY-P2816
CAS No.: 37278-89-0
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Xylanase is an enzyme targeting 1,4-β-D-xylan that randomly cleaves the β-1,4 backbone of xylan, a complex polysaccharide in plant cell walls. Xylanase finds applications in the food, feed and industrial sectors, including pulp and paper processing, baking, animal feed improvement, and biotransformation of waste .
Synonyms: 6M Guanidinium chloride Solution; 6M Aminoformamidine hydrochloride Solution
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6M Guanidine hydrochloride Solution (6M Guanidinium chloride Solution) is a strong protein denaturant. 6M Guanidine hydrochloride Solution causes proteins to assume a random coil conformation .
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Levanase is a slime-dissolving enzyme of Rhodotorula species. Levanase performs random hydrolysis of β-2,6 fructofuranosyl linkages in β-2,6 fructans containing more than 3 fructose units .
Cat. No.: HY-153840A
Purity: 97.03%
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ODN INH-18 sodium is a linear 24-mer class B INH-ODN in which the 5' INH-ODN 4084-F sequence was followed by a random stretch of 12 nucleotides lacking the ability to form significant secondary structures. ODN INH-18 sodium showes inhibitory potency for TLR9 ligand-induced IFN-α production.
Cat. No.: HY-16632
CAS No.: 1333990-84-3
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ELND 006 (Compound 30) is a metabolically stable γ-secretase inhibitor designed to selectively inhibit amyloid beta (Aβ) generation while sparing Notch signaling. It was developed through a synthetic strategy emphasizing diversity and chirality. ELND 006, along with its analog ELND007 (Compound 34), progressed into human clinical trials. In preclinical studies, both compounds demonstrated effective reduction of Aβ levels in vitro and in vivo. Comparisons with other γ-secretase inhibitors like Semagacestat, Begacestat, and Avagacestat underscored their potency and specificity in lowering Aβ levels in cerebrospinal fluid (CSF) of healthy human volunteers, suggesting potential therapeutic efficacy in Alzheimer's disease .
Cat. No.: HY-N8671
CAS No.: 256520-90-8
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Cat. No.: HY-E70185
Synonyms: EC:3.2.1.24; MAN2B1; LAMAN
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Lysosomal α-mannosidase (EC:3.2.1.24) is a low pH-activated exoglycosidase that hydrolyzes α-mannosidic linkages on mannan and N-linked oligosaccharides, and its activation requires Zn 2+. As the major exoglycosidase in the glycoprotein degradation pathway, lysosomal α-mannosidase cleaves α1,2-, α1,3- and α1,6-mannosidic linkages during a non-random, ordered degradation process to generate Man1GlcNAc1-2 for further lysosomal processing. Lysosomal α-mannosidase can be used in studies related to α-mannosidosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
