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solid-phase synthesis building block

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (1) ADC Linker (1) Amino Acid Derivatives (9) Amyloid-β (1) Biochemical Assay Reagents (5) Drug Derivative (1) Drug Intermediate (11) Isotope-Labeled Compounds (2) Reference Standards (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Peptides

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1636

Fmoc-Arg(Pbf)-OH	Amino Acid Derivatives Drug Intermediate	Metabolic Disease
Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .

HY-W008558

Fmoc-N-Me-Leu-OH	Amino Acid Derivatives	Others
Fmoc-N-Me-Leu-OH is an N-Fmoc-N-methyl amino acid that can be used in peptide coupling reactions. Fmoc-N-Me-Leu-OH is primarily used as a standard building block in solid-phase peptide synthesis (SPPS) to introduce N-methylleucine residues into peptide chains, thereby enhancing the enzymatic stability, altering conformational flexibility, and modifying the biological activity of the target peptide .

HY-104004

Fmoc-Ser(O-α-D-GalNAc(OAc)3)-OH Fmoc-Ser-(GalNAc(Ac)3-alpha-D)-OH; Fmoc-Ser[GalNAc(Ac)3-α-D]-OH; Fmoc-Ser(Ac3AcNH-α-Gal)-OH	Amino Acid Derivatives Drug Intermediate	Cancer
Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH (Fmoc-Ser-(GalNAc(Ac)3-alpha-D)-OH) is a protected glycosylated amino acid and Tn antigen. Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH serves as a building block in the solid-phase synthesis of Tn-based cancer vaccine constructs. Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH supports solid-phase peptide synthesis .

HY-W008235

Fmoc-N-Me-Ala-OH	Amino Acid Derivatives Drug Intermediate	Cancer
Fmoc-N-Me-Ala-OH is an Fmoc-protected N-methyl-L-alanine and also a building block for solid-phase peptide synthesis. As a building block, Fmoc-N-Me-Ala-OH is used to synthesize peptidomimetic antagonists of XIAP BIR3 derived from Smac/DIABLO .

HY-W111226

Fmoc-His(3-Me)-OH	Amyloid-β Amino Acid Derivatives	Cardiovascular Disease Neurological Disease
Fmoc-His (3-Me)-OH is a histidine derivative with a methylated imidazole group. Fmoc-His (3-Me)-OH can be used for the synthesis of the chemically modified tripeptide His (3-methyl)-Arg-Trp (H (3-Me)-RW). Fmoc-His (3-Me)-OH serves as a resin in Fmoc solid-phase synthesis for the generation of the His-(3-Me)-Gly-Lys peptide. Fmoc-His (3-Me)-OH is a building block for the synthesis of NAHIS02-(p-Met). Fmoc-His (3-Me)-OH can be applied in research related to Alzheimer's disease .

HY-W024615

Me-diazirine-cooh 3-(3-Methyl-3H-diazirin-3-yl)propanoic acid	Drug Intermediate Biochemical Assay Reagents	Others
Me-diazirine-cooh (3-(3-Methyl-3H-diazirin-3-yl) propanoic acid) is a molecular building block containing an aliphatic diazirine ring. Me-diazirine-cooh undergoes orthogonal coupling in solid-phase peptide synthesis to introduce the Diazirine group into collagen-mimetic peptides. Me-diazirine-cooh is used to construct the photoaffinity probe P1 .

HY-Y1636S

Fmoc-Arg(Pbf)-OH-13C6,15N4	Isotope-Labeled Compounds Amino Acid Derivatives Drug Intermediate	Metabolic Disease
Fmoc-Arg(Pbf)-OH- ¹³C₆, ¹⁵N₄ is the ¹³C-labeled and ¹⁵N-labeled Fmoc-Arg(Pbf)-OH (HY-Y1636). Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .

HY-179477

Fmoc-β-Ala-Asp(OMpe)-OH	Amino Acid Derivatives Drug Intermediate	Others
Fmoc-β-Ala-Asp(OMpe)-OH is a specialized amino acid derivative used in solid-phase peptide synthesis (SPPS). Fmoc-β-Ala-Asp(OMpe)-OH consists of a beta-alanine spacer linked to an aspartic acid residue, where the beta-carboxyl group is protected with a 3-methylpentyl ester (OMpe) to prevent aspartimide formation during synthesis. Fmoc-β-Ala-Asp(OMpe)-OH a useful building block for creating peptides that contain aspartic acid, as the OMpe group is designed to minimize unwanted side reactions .

HY-W784626

Boc-PNA-T-OH	Drug Intermediate	Others
Boc-PNA-T-OH is a thymine-containing peptide nucleic acid monomer and solid-phase synthesis building block .

HY-151825

Fmoc-L-Phe(4-NH-Poc)-OH	ADC Linker	Others
Fmoc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in solid-phase peptide synthesis. Poc-group can be further modified using Click-chemistry .

HY-Y1636S1

Fmoc-Arg(Pbf)-OH-13C6	Isotope-Labeled Compounds Amino Acid Derivatives Drug Intermediate	Others
Fmoc-Arg(Pbf)-OH- ¹³C₆ is the ¹³C labeled Fmoc-Arg(Pbf)-OH . Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .

HY-P11692

Fmoc-Aeg-OtBu	Drug Intermediate	Others
Fmoc-Aeg-OtBu is an intermediate in solid-phase peptide synthesis, and serves as a building block for introducing pseudoproline motifs or backbone modifications .

HY-P4613

Fmoc-D-allo-Thr-OH	Drug Derivative Drug Intermediate	Others
Fmoc-D-allo-Thr-OH is a derivative of D-allothreonine (HY-W001959), which is commonly used as a building block in solid-phase peptide synthesis (SPPS) .

HY-W871908

Boc-Aeg(Fmoc)-OH	Biochemical Assay Reagents	Others
Boc-Aeg(Fmoc)-OH is a Boc/Fmoc-protected 2-aminoethylglycine building block. Boc-Aeg(Fmoc)-OH facilitates solid-phase synthesis of acridine oligomers with a (2-aminoethyl)glycine backbone .

HY-P11689

Fmoc-PNA-J(Bhoc)-OH	Biochemical Assay Reagents	Others
Fmoc-PNA-J (Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer building block used for solid-phase synthesis of PNA oligomers. Fmoc-PNA-J (Bhoc)-OH carries Fmoc/Bhoc protecting groups and functions as a standard Fmoc-protected PNA monomer .

HY-P11679

Boc-PNA-U-OH	DNA/RNA Synthesis	Others
Boc-PNA-U-OH is a protected peptide nucleic acid (PNA) monomer containing a uracil base, designed for solid-phase peptide synthesis (SPPS) using the Boc/Z protection strategy. Boc-PNA-U-OH acts as a building block in creating PNA oligomers that are neutral, stable, and used for antisense/antigene applications.

HY-104004R

Fmoc-Ser(O-α-D-GalNAc(OAc)3)-OH (Standard) Fmoc-Ser-(GalNAc(Ac)3-alpha-D)-OH (Standard); Fmoc-Ser[GalNAc(Ac)3-α-D]-OH (Standard); Fmoc-Ser(Ac3AcNH-α-Gal)-OH (Standard)	Amino Acid Derivatives Reference Standards Drug Intermediate	Cancer
Fmoc-Ser(O-α-D-GalNAc(OAc)3)-OH (Standard) is the analytical standard of Fmoc-Ser(O-α-D-GalNAc(OAc)3)-OH (HY-104004). This product is intended for research and analytical applications. Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH (Fmoc-Ser-(GalNAc(Ac)3-alpha-D)-OH) is a protected glycosylated amino acid and Tn antigen. Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH serves as a building block in the solid-phase synthesis of Tn-based cancer vaccine constructs. Fmoc-Ser (O-α-D-GalNAc (OAc) 3)-OH supports solid-phase peptide synthesis .

HY-P11688

Fmoc-PNA-M(Bhoc)-OH	Biochemical Assay Reagents	Others
Fmoc-PNA-M (Bhoc)-OH is a standard peptide nucleic acid (PNA) monomer building block. Fmoc-PNA-M (Bhoc)-OH carries two protecting groups, Fmoc and Bhoc, and is specifically designed for solid-phase and automated PNA synthesis. Fmoc-PNA-M (Bhoc)-OH efficiently participates in the construction of sequence-specific PNA probes. Through its protecting group strategy, Fmoc-PNA-M (Bhoc)-OH ensures the accuracy and efficiency of PNA synthesis, and is one of the important raw materials for PNA synthesis at present .

HY-W540123

Fmoc-PNA-A(Bhoc)-OH	Biochemical Assay Reagents	Cancer
Fmoc-PNA-A(Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer carrying an adenine base. Fmoc-PNA-A(Bhoc)-OH contains Fmoc and benzhydryloxycarbonyl (Bhoc) protecting groups, and serves as a standard building block designed specifically for solid-phase PNA synthesis. Fmoc-PNA-A(Bhoc)-OH can be efficiently used to synthesize PNA-based sequence-specific hybridization probes. These probes have broad applications in molecular biology research; for example, they can be used in HER2-expressing tumor-related studies, providing tools for disease diagnosis and mechanism exploration .

Cat. No.	Product Name	Target	Research Area

HY-Y1636

Fmoc-Arg(Pbf)-OH	Amino Acid Derivatives Drug Intermediate	Metabolic Disease
Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .

HY-W111226

Fmoc-His(3-Me)-OH	Amyloid-β Amino Acid Derivatives	Cardiovascular Disease Neurological Disease
Fmoc-His (3-Me)-OH is a histidine derivative with a methylated imidazole group. Fmoc-His (3-Me)-OH can be used for the synthesis of the chemically modified tripeptide His (3-methyl)-Arg-Trp (H (3-Me)-RW). Fmoc-His (3-Me)-OH serves as a resin in Fmoc solid-phase synthesis for the generation of the His-(3-Me)-Gly-Lys peptide. Fmoc-His (3-Me)-OH is a building block for the synthesis of NAHIS02-(p-Met). Fmoc-His (3-Me)-OH can be applied in research related to Alzheimer's disease .

HY-W784626

Boc-PNA-T-OH	Drug Intermediate	Others
Boc-PNA-T-OH is a thymine-containing peptide nucleic acid monomer and solid-phase synthesis building block .

HY-P11692

Fmoc-Aeg-OtBu	Drug Intermediate	Others
Fmoc-Aeg-OtBu is an intermediate in solid-phase peptide synthesis, and serves as a building block for introducing pseudoproline motifs or backbone modifications .

HY-P4613

Fmoc-D-allo-Thr-OH	Drug Derivative Drug Intermediate	Others
Fmoc-D-allo-Thr-OH is a derivative of D-allothreonine (HY-W001959), which is commonly used as a building block in solid-phase peptide synthesis (SPPS) .

HY-W871908

Boc-Aeg(Fmoc)-OH	Biochemical Assay Reagents	Others
Boc-Aeg(Fmoc)-OH is a Boc/Fmoc-protected 2-aminoethylglycine building block. Boc-Aeg(Fmoc)-OH facilitates solid-phase synthesis of acridine oligomers with a (2-aminoethyl)glycine backbone .

HY-P11689

Fmoc-PNA-J(Bhoc)-OH	Biochemical Assay Reagents	Others
Fmoc-PNA-J (Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer building block used for solid-phase synthesis of PNA oligomers. Fmoc-PNA-J (Bhoc)-OH carries Fmoc/Bhoc protecting groups and functions as a standard Fmoc-protected PNA monomer .

HY-P11679

Boc-PNA-U-OH	DNA/RNA Synthesis	Others
Boc-PNA-U-OH is a protected peptide nucleic acid (PNA) monomer containing a uracil base, designed for solid-phase peptide synthesis (SPPS) using the Boc/Z protection strategy. Boc-PNA-U-OH acts as a building block in creating PNA oligomers that are neutral, stable, and used for antisense/antigene applications.

HY-P11688

Fmoc-PNA-M(Bhoc)-OH	Biochemical Assay Reagents	Others
Fmoc-PNA-M (Bhoc)-OH is a standard peptide nucleic acid (PNA) monomer building block. Fmoc-PNA-M (Bhoc)-OH carries two protecting groups, Fmoc and Bhoc, and is specifically designed for solid-phase and automated PNA synthesis. Fmoc-PNA-M (Bhoc)-OH efficiently participates in the construction of sequence-specific PNA probes. Through its protecting group strategy, Fmoc-PNA-M (Bhoc)-OH ensures the accuracy and efficiency of PNA synthesis, and is one of the important raw materials for PNA synthesis at present .

HY-W540123

Fmoc-PNA-A(Bhoc)-OH	Biochemical Assay Reagents	Cancer
Fmoc-PNA-A(Bhoc)-OH is a protected peptide nucleic acid (PNA) monomer carrying an adenine base. Fmoc-PNA-A(Bhoc)-OH contains Fmoc and benzhydryloxycarbonyl (Bhoc) protecting groups, and serves as a standard building block designed specifically for solid-phase PNA synthesis. Fmoc-PNA-A(Bhoc)-OH can be efficiently used to synthesize PNA-based sequence-specific hybridization probes. These probes have broad applications in molecular biology research; for example, they can be used in HER2-expressing tumor-related studies, providing tools for disease diagnosis and mechanism exploration .

Cat. No.	Product Name	Chemical Structure

HY-Y1636S

Fmoc-Arg(Pbf)-OH-13C6,15N4
Fmoc-Arg(Pbf)-OH- ¹³C₆, ¹⁵N₄ is the ¹³C-labeled and ¹⁵N-labeled Fmoc-Arg(Pbf)-OH (HY-Y1636). Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .

HY-Y1636S1

Fmoc-Arg(Pbf)-OH-13C6
Fmoc-Arg(Pbf)-OH- ¹³C₆ is the ¹³C labeled Fmoc-Arg(Pbf)-OH . Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .

Cat. No.	Product Name		Classification

HY-151825

Fmoc-L-Phe(4-NH-Poc)-OH		Alkynes
Fmoc-L-Phe(4-NH-Poc)-OH is a click chemistry reagent containing an azide group. Used as an orthogonally protected building block in solid-phase peptide synthesis. Poc-group can be further modified using Click-chemistry .

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