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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
somatostatin secretion
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "somatostatin secretion" in MCE Product Catalog:
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1 Cited Publications
Cat. No.: HY-P1206
CAS No.: 174688-78-9
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CH 275 is a peptidic somatostatin analog that acts as an agonist of SST1 (IC50 = 30.9 nM, Ki = 52 nM). The IC50 values of CH 275 for sst3, sst4, sst2, and sst5 are 345 nM, >1 μM, >10 μM, and >10 μM, respectively. CH 275 binds to SSTR1 via the IAmp9-Asp137 ion pair interaction and the hydrophobic interaction between the isopropyl group of IAmp9 and Leu107, and reduces the extracellular acidification rate. CH 275 induces weak sst1 internalization, exerts immunosuppressive effects on macrophages, and decreases macrophage viability, MCP-1 expression/secretion, and IL-8 secretion, but does not alter proMMP-9 secretion or IL-8 mRNA levels. CH 275 reduces hippocampal β-amyloid levels and alleviates plaque pathology without inducing hippocampal microglial activation. CH 275 is used in research on Alzheimer's disease, Parkinson's disease, and depression .
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1 Cited Publications
Cat. No.: HY-P1547
CAS No.: 76461-17-1
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Cat. No.: HY-P3954
CAS No.: 73032-94-7
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Cat. No.: HY-P3579
CAS No.: 11063-17-5
Synonyms: GIP (1-42), porcine
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Synonyms: MK-678; L-363586
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Cat. No.: HY-P3019
CAS No.: 357952-09-1
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Cat. No.: HY-P0024A
CAS No.: 2126831-23-8
Synonyms: DG3173 TFA; PTR-3173 TFA
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Cat. No.: HY-P3019A
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Cardiovascular Disease Neurological Disease Metabolic Disease
Cat. No.: HY-P0024
CAS No.: 252845-37-7
Synonyms: DG3173; PTR-3173
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Cat. No.: HY-164040
CAS No.: 2604416-66-0
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Zavolosotine (Compound 1) is an orally active agonist for somatostatin receptor type 5 (SST5) with EC50 <1 nM. Zavolosotine inhibits insulin and glucagon secretion, increases levels of glucagon in blood in rat model .
Cat. No.: HY-110161
CAS No.: 1021912-42-4
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sst2 Receptor agonist-1 is a potent somatostatin receptor subtype 2 (sst2) agonist with a Ki value of 0.025 nM and a cAMP IC50 value of 4.8 nM. sst2 Receptor agonist-1 can inhibit rat growth hormone (GH) secretion and ocular neovascular lesion formation. Antiangiogenic effect .
Cat. No.: HY-P0221B
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Cat. No.: HY-175053
Synonyms: SOM230 (aspartate) TFA
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Cat. No.: HY-P2167
CAS No.: 99685-66-2
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Somatostatin RC-102 is an octapeptide analog of Somatostatin. Somatostatin RC-102 inhibits the release of growth hormone and insulin. Somatostatin RC-102 enhances the inhibition of cell migration by increasing the production or activity of LMIF, but exerts no effect on cell migration in the absence of exposure to cardiac antigens or phytohemagglutinin. Somatostatin RC-102 inhibits gastric acid secretion. Somatostatin RC-102 can be used in the research of heart diseases .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
