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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
120 Results for "
tablet crushing strength
" in MedChemExpress (MCE) Product Catalog:
Products (120)
120 Results for "tablet crushing strength" in MCE Product Catalog:
263
263 Publications Verification
Cat. No.: HY-K0011
MCE Protease Inhibitor Cocktail, mini-Tablet (EDTA-Free) is a blend of 5 pan-protease inhibitors for protection of protein integrity. The 25 pcs is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
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C188-9 (TTI-101) is a STAT3 inhibitor with a Kd value of 4.7 nM. C188-9 targets the SH2 domain of STAT3, blocks the processes of STAT3 ligand binding, receptor recruitment, homodimerization and phosphorylation, and regulates STAT3-mediated genes associated with tumorigenesis and radioresistance. C188-9 regulates STAT1-mediated genes related to radioresistance and reduces the activation level of STAT1. C188-9 downregulates the expression of DNMT1, enhances DAC-induced demethylation and re-expression of RASSF1A, and simultaneously potentiates the anti-tumor effect of DAC on pancreatic cancer cells. C188-9 inhibits both anchorage-dependent and anchorage-independent growth of cancer cells, induces Apoptosis, blocks the growth of tumor xenografts, and suppresses muscle atrophy. C188-9 maintains muscle mass, increases body weight and improves grip strength in tumor-bearing mice. C188-9 can be used in research related to head and neck squamous cell carcinoma, pancreatic cancer, sepsis-related skeletal muscle wasting, non-small cell lung cancer, acute myeloid leukemia and cancer cachexia .
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7 Cited Publications
Cat. No.: HY-18102
CAS No.: 1215085-92-9
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GLPG0492 is an orally active, non-steroidal selective androgen receptor modulator. GLPG0492 exerts functional transactivation by binding to the ligand-binding domain of the receptor, exhibiting preferential partial agonist activity in muscle and bone tissues with low activity in reproductive tissues. GLPG0492 effectively counteracts muscle atrophy-related pathways, significantly enhances muscle strength, maintains motor ability, reduces fibrosis and improves electrophysiological parameters. GLPG0492 prevents immobilization-induced muscle atrophy and regulates muscle mass homeostasis, serving as a valuable tool compound for studies on Duchenne muscular dystrophy, muscle loss and various types of disuse musculoskeletal atrophy .
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Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology Endocrinology
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5 Cited Publications
Cat. No.: HY-44076
CAS No.: 85073-19-4
Synonyms: Lithium phenyl-2,4,6-trimethylbenzoylphosphinate
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5 Cited Publications
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UCL-TRO-1938 is a potent small molecule allosteric activator of PI3Kα with an EC50 value of approximately 60 μM. UCL-TRO-1938 can induce cell proliferation and has cardioprotective effects from ischaemia reperfusion injury and enhances nerve regeneration following nerve crush .
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4 Cited Publications
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CHAPS is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm-Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS is commonly used in research on the separation and purification of membrane proteins .
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4 Cited Publications
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Tulobuterol (C-78 free base) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol is also a sympathomimetic agent used as a transdermal patch, and increases normal diaphragm muscle strength .
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Tulobuterol hydrochloride (C-78) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol hydrochloride is also a sympathomimetic agent used as a transdermal patch, increases normal diaphragm muscle strength . Tulobuterol hydrochloride inhibit rhinovirus replication and modulate airway inflammation .
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2 Cited Publications
Cat. No.: HY-P5411
CAS No.: 148274-88-8
Synonyms: SIITFEKL, OVA (257-264) Variant
OVA-T4 Peptide (SIITFEKL; OVA (257-264) Variant) is a modified peptide ligand of OVA 257-264 that binds to mouse OT-I TCR with Kd = 1.22 μM, acts as a weaker agonist than the parental N4 peptide to modulate the strength of antigen-presenting cell-T lymphocyte interactions, and alters the amplitude of cytokine responses and NFAT1, p-Erk, and NF-κB signaling responses. OVA-T4 Peptide can be used for research on colon cancer and ovarian cancer .
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1 Cited Publications
Cat. No.: HY-P99370
CAS No.: 1391726-30-9
Synonyms: LY2495655; Anti-GDF8 / Myostatin Reference Antibody (landogrozumab)
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Cross-linked dextran G 25 is a cross-linked dextran gel chromatography medium that possesses multiple separation activities, including molecular sieve effects, weak anion exchange, and aromatic adsorption. Cross-linked dextran G 25 weakly exchanges cations through immobilized terminal carboxyl groups and repels anions at low ionic strength. Cross-linked dextran G 25 is used for the fractionation of low molecular weight solutes, including peptides, amino acids, nucleotide sugar derivatives, and aromatic compounds .
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1 Cited Publications
Synonyms: Bromosalicylchloranilide; Salifungin
Multifungin (Bromochlorosalicylanilide) is an antifungal that treats oral candidiasis . Multifungin prevents the formation and accumulation of Zearalenone and reduces the fungal population in stored-crushed corn .
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1 Cited Publications
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DN-1289 is an orally active and selective inhibitor of dual leucine zipper kinase (DLK; IC50=17 nM) and leucine zipper-bearing kinase (LZK; IC50=40 nM). DN-1289 results significant attenuation of optic nerve crush (ONC)-induced p-c-Jun in mice model. DN-1289 has excellent in vivo plasma half-life and blood-brain barrier permeability .
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1 Cited Publications
Cat. No.: HY-B2221B1
CAS No.: 9004-62-0
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Hydroxyethyl cellulose, Viscosity(2%):150mPa.s is a class of nonionic cellulose ether gel-forming polymers with pH-independent drug release properties. When used as a tablet coating, Hydroxyethyl cellulose, Viscosity(2%):150mPa.s regulates the water permeation rate, thereby altering the drug release lag time; the higher the viscosity, the longer the drug release lag time. When used as a hydrogel thickener, it increases the dynamic viscosity of the system. Hydroxyethyl cellulose, Viscosity(2%):150mPa.s can be used in organic synthesis-related research, such as pharmaceutical excipients, hydrogel thickeners, etc.
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N-Chlorosuccinimide (Succinchlorimide) is an oxidizing, hydrolyzable biochemical reagent with bactericidal and amoebicidal activities. N-Chlorosuccinimide can either form N-chloramines via concerted transfer of Cl + or hydrolyze in aqueous solution to produce hypochlorous acid/hypochlorite. N-Chlorosuccinimide is effective in killing Shigella dysenteriae, Escherichia typhi and cysts of Entamoeba histolytica. N-Chlorosuccinimide can be formulated into fast-dispersing, fully soluble water purification tablets. N-Chlorosuccinimide is used in studies related to bacterial infections and parasitic infections .
Synonyms: EDG-5506
Sevasemten is an orally active, selective allosteric inhibitor of skeletal muscle myosin that protects skeletal muscle from contraction-induced injury. Sevasemten decreases muscle damage biomarkers and fibrosis while increasing muscle strength and activity in in Duchenne muscular dystrophy disease models .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
