83 Results for "

thiazole

" in MedChemExpress (MCE) Product Catalog:
Products (83)

83 Results for "thiazole" in MCE Product Catalog:

26
26 Publications Verification
Referencia número: HY-B0990
No. CAS: 1393-48-2
Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation .
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13
13 Cited Publications
Referencia número: HY-108896
No. CAS: 138614-30-9
Pureza:  99.85%
Synonyms: HOE 140 acetate
Target:  

Bradykinin Receptor

Áreas de investigación:  

Inflammation/Immunology

Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively .
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1
1 Cited Publications
Referencia número: HY-D0150
No. CAS: 107091-89-4
Thiazole Orange is an asymmetric anthocyanin dye that can be coupled with oligonucleotides (ONs) to prepare fluorescent hybridization probes. Thiazole Orange has been widely used in biomolecular detection and staining of DNA/ RNA in gels and can be used for reticulocyte analysis. Thiazole orange generates a significant fluorescence enhancement and high quantum yield when it binds with nucleic acids, especially RNA. Thiazole orange can permeate living cell membranes. Thiazole orange can use UV light for detection, but can also be detected with blue light. The excitation and emission of Thiazole orange are λex = 510 nm (488 nm and 470 nm also show strong excitation) and λem = 527 nm, respectively .
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1
1 Cited Publications
Referencia número: HY-W003182
No. CAS: 53218-26-1
6-Bromobenzo[d]thiazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Referencia número: HY-101511
No. CAS: 1609138-51-3
Pureza:  99.62%
Target:  

P-glycoprotein

Áreas de investigación:  

Cancer

TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1)-mediated multidrug resistance (MDR) by selectively blocking the efflux function of ABCB1 .
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Referencia número: HY-D0996
No. CAS: 181885-68-7
Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 is a nucleic acid stain that mainly detects DNA. Lds-751 has a high affinity for DNA and fluorescence is enhanced after binding, but the maximum emission wavelength is 670nm. Lds-751 and Thiazole orange can be used for the differentiation of red blood cells, platelets, reticulocytes, and nucleated cells and can be stimulated at 488nm. Studies have shown that LDS-751 binds almost exclusively to mitochondria when incubated with nucleated living cells. After nucleated Acridine Orange (HY-101879) staining and LDS-751 treatment of cells, confocal microscopy revealed almost no co-location of the cells. Staining with Rhodamine 123 (HY-D0816), a dye known to bind polarized mitochondria, was almost identical to the pattern observed with LDS-751 .
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Referencia número: HY-Y0135
No. CAS: 532-24-1
Target:  

Drug Intermediate

Áreas de investigación:  

Cancer

Tropinone is an organic synthesis intermediate and a skeleton for constructing derivatives containing thiazole rings and other structures. Tropinone derivatives have anticancer activities such as inducing tumor cell apoptosis and inhibiting tyrosinase activity, and can be used in research such as anticancer drug development and tyrosinase inhibitor design .
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Referencia número: HY-D0916
No. CAS: 143413-85-8
Synonyms: YOYO 1; YOYO1
Thiazole orange dimer YOYO 1 (YOYO 1) is a cell-impermeable cyanine dimer with no inherent fluorescence, and its fluorescence intensity increases significantly upon binding to double-stranded DNA (dsDNA) . Thiazole orange dimer YOYO 1 can serve as a nuclear counterstain or a dead cell indicator (Ex/Em = 505/512 nm).
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Referencia número: HY-115406A
No. CAS: 2321332-57-2
Target:  

Apoptosis

Áreas de investigación:  

Cancer

CPTH6 hydrobromide is a thiazole derivative which activates apoptotic program and increases autophagic features in human acute myeloid leukemia cell lines. CPTH6 can be used for cancer research .
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Referencia número: HY-U00094
No. CAS: 14782-19-5
Target:  

Drug Derivative

Áreas de investigación:  

Inflammation/Immunology

INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity .
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Referencia número: HY-148134
No. CAS: 55040-82-9
Pureza:  98.04%
Target:  

Lipoxygenase

Áreas de investigación:  

Inflammation/Immunology

5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase (5-LOX) with an IC50 value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation .
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Referencia número: HY-69015
No. CAS: 1003-32-3
Synonyms: thiazole-5-carboxaldehyde; 5-Formylthiazole
Thiazole-5-carboxyaldehyde is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Referencia número: HY-153847
Áreas de investigación:  

Others

RNA Aptamer Mango Ⅱ (sodium) has an exceptionally high affinity to TO1-biotin (a thiazole orange derivative fluorophore), and can be used to visualize RNA expression or localization in live cells. Compared to the original Mango I aptamer, RNA Aptamer Mango Ⅱ (sodium) has markedly improved fluorescent properties, binding affinities, and salt dependencies.
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Referencia número: HY-113752
No. CAS: 902630-14-2
Pureza:  99.54%
Target:  

Parasite

Áreas de investigación:  

Infection

MMV019313 is a potent, non-bisphosphonate inhibitor of farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) with an IC50 of 0.82 µM. MMV019313 has activity against P. falciparum (Parasite) .
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Referencia número: HY-Y0425
No. CAS: 623-27-8
Terephthalaldehyde is a crosslinking agent. Terephthalaldehyde forms a crosslinked structure inside the gelatin matrix by forming Schiff base imines with the amino groups of gelatin, thereby constructing a three-dimensional network. Terephthalaldehyde improves the hydrophobicity of the gelatin matrix, delays water vapor penetration and enhances the liquid water resistance of gelatin films. Terephthalaldehyde can be used as a crosslinking agent to prepare crosslinked chitosan hydrogel (CAAT) via ultrasound-induced synthesis. Terephthalaldehyde helps CAAT hydrogels selectively adsorb anionic dyes from aqueous media, including multi-component systems containing cationic dyes. Terephthalaldehyde serves as a starting material for the synthesis of bis-heterocyclic compounds (including bis-thiazole and bis-triazolopyrimidine compounds) .
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Referencia número: HY-W158239
No. CAS: 144059-86-9
Target:  

Drug Metabolite

Áreas de investigación:  

Others

4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid is a metabolite of GW 501516 (HY-10838) .
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Referencia número: HY-W010594
No. CAS: 1003-04-9
Tetrahydrothiophen-3-one is an endogenous metabolite. Tetrahydrothiophen-3-one is a pharmaceutical intermediate that can be used to synthesize thiazole compounds. Tetrahydrothiophen-3-one exists in natural food and has good safety .
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Referencia número: HY-W110909
No. CAS: 1829-00-1
Synonyms: Titan yellow; Clayton Yellow
Thiazole yellow G, for microscopy is a cationic basic thiazine dye. Thiazole yellow G can be used for the determination of uranium and thorium .
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Referencia número: HY-W153810
No. CAS: 1826-16-0
Target:  

Drug Intermediate

Áreas de investigación:  

Others

2-Methyl-4-phenyl thiazole is a synthetic intermediate useful for pharmaceutical synthesis.
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Referencia número: HY-W012428
No. CAS: 39091-01-5
Target:  

Drug Intermediate

Áreas de investigación:  

Others

2-(3-Pyridyl)-4-methyl-thiazole-5-carboxylic acid is a synthetic intermediate useful for pharmaceutical synthesis.
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