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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
trypsin-like
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "trypsin-like" in MCE Product Catalog:
18
18 Publications Verification
Synonyms: Salinosporamide A; NPI-0052
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Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .
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TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation .
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N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.
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1 Cited Publications
Cat. No.: HY-18741
CAS No.: 1624602-30-7
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VR23 is a small molecule that potently inhibits the activities of trypsin-like proteasomes (IC50=1 nM), chymotrypsin-like proteasomes (IC50=50-100 nM), and caspase-like proteasomes (IC50=3 μM).
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1 Cited Publications
Synonyms: Fluorogenic Proteasome Substrate; Z-ARR-AMC
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Cat. No.: HY-P4326
CAS No.: 65147-04-8
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20S Proteasome activator 1 is a potent 20S proteasome activator with EC200 values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases .
Cat. No.: HY-135070
CAS No.: 929903-87-7
Synonyms: Ac-Arg-Leu-Arg-AMC
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Bovine Factor Xa, a trypsin-like serine protease, is an important player in the coagulation cascade responsible for thrombin generation .
Cat. No.: HY-P2483B
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Cat. No.: HY-P2483
CAS No.: 148796-86-5
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Cat. No.: HY-P5280
CAS No.: 1104011-51-9
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Cat. No.: HY-P11331
CAS No.: 1356828-49-3
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Cat. No.: HY-137897
CAS No.: 87779-49-5
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Cat. No.: HY-151611
CAS No.: 2842774-51-8
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UAMC-00050 is a potent trypsin-like serine protease inhibitor. UAMC-00050 can be used in research of dry eye syndrome and ocular inflammation .
Cat. No.: HY-118522
CAS No.: 688737-95-3
TP-110 is a proteasome inhibitor. TP-110 specifically inhibits the protease-like activity of the 20S proteasome, but does not affect the trypsin-like or peptidyl-glutamyl peptide hydrolysis activity. TP-110 inhibits the NF-κB pathway, activates caspase-8, -9, and -3, and causes PARP cleavage, significantly reducing the levels of cIAP-1 and XIAP. TP-110 causes cell cycle arrest at the G2/M phase and promotes apoptosis of cancer cells. TP-110 can be used in cancer research of prostate cancer and multiple myeloma, etc .
Cat. No.: HY-137281
CAS No.: 862891-04-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
