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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
tryptase
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "tryptase" in MCE Product Catalog:
4
Target:
Research Areas:
Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .
2
2 Cited Publications
Cat. No.: HY-P76377
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GZMA; Cytotoxic T-Lymphocyte Proteinase 1; Prev. CTLA3; Granzyme 1; Prev. HFSP; H Factor; CTL tryptase; HF; Fragmentin-1; Granzyme A (Cytotoxic T-Lymphocyte-Associated Serine Esterase-3; Hanukah Factor Serine Protease); Granzyme A (Granzyme 1, Cytotoxic T
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71131
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TPSB2; tryptase Beta III; tryptase Beta 2; tryptase Beta II; Testicular Tissue Protein Li 163; TPSB2 Protein; tryptase Beta-2; tryptase II; TPS2; tryptase-2; tryptase Beta 2 (Gene/Pseudogene); tryptaseB; Mast Cell tryptase Beta III; tryptaseC; Mast Cell T
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P702812
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GZMK; tryptase II; Granzyme K; Granzyme-3; TRYP2; NK-Tryp-2; Fragmentin-3; PRSS; Granzyme K (Serine Protease, Granzyme 3; tryptase II); GrK; Granzyme K (Granzyme 3; tryptase II); Granzyme 3; NK-tryptase-2
Species:
Mouse
Source:
E. coli
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Research Areas:
FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5 µM, respectively .
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BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC50 of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC50=5 nM). BMS-262084 exhibits antithrombotic effects .
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Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride is a chromogenic peptide substrate used for trypsin and tryptase-like serine proteases. Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride releases p-nitroaniline upon hydrolysis, which can be detected by absorbance. Nα-Benzoyl-L-arginine 4-nitroanilide hydrochloride can be used in studies of A1PI degradation .
Cat. No.: HY-19303B
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CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ) .
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APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma .
Cat. No.: HY-P10144
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Cat. No.: HY-P4462
CAS No.: 122630-72-2
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Cat. No.: HY-120624
CAS No.: 708258-16-6
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BMS-354326 is a tryptase inhibitor with an IC50 of 1.8 nM. BMS-354326 exhibits excellent selectivity against trypsin and most other related serine proteases. BMS-354326 can be used in the research of asthma and inflammatory diseases .
Cat. No.: HY-19303
CAS No.: 256649-36-2
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CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ) .
Cat. No.: HY-P10144A
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Cat. No.: HY-P11418
CAS No.: 74661-31-7
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Cat. No.: HY-105999B
CAS No.: 2421110-28-1
Research Areas:
APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases .
Cat. No.: HY-116033
CAS No.: 384829-65-6
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BMS-363131 is a selective inhibitor for tryptase, with an IC50 <1.7 nM. BMS-363131 is hydrolytic stable at pH=7 and pH=9. BMS-363131 attenuates the astham in a guinea pig model .
Cat. No.: HY-15132
CAS No.: 583868-50-2
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Research Areas:
MOL-6131 is a highly selective, reversible tryptase inhibitor, with a Ki of 45 nM. MOL-6131 significantly reduces the following features of allergic airway inflammation: eosinophil infiltration in lung tissue, goblet cell hyperplasia and mucus occlusion of airways .
Cat. No.: HY-170768
Alkaline tryptase-IN-1 (compound H-13) is an insecticide that targets alkaline tryptase. The LC50 of Alkaline tryptase-IN-1 inhibits Aphid graminearum, Schizaphis graminearum, Aphid natans, Aphid oleraceus, Aphid fusca, Aphid mariana, and Myzus persicae with concentrations of 8.72, 13.77, 14.17, 12.96, and 12.35 μg/mL, respectively .
Cat. No.: HY-19303A
Target:
Research Areas:
CRA-2059 hydrochloride is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
