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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
viral polyprotein processing
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "viral polyprotein processing" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-78726
CAS No.: 226700-79-4
Synonyms: Amprenavir phosphate; GW 433908
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Pomotrelvir is a selective, competitive, orally active covalent inhibitor of the SARS-CoV-2 main protease (M pro), with an IC50 of 24 nM for wild-type SARS-CoV-2 M pro. Pomotrelvir inhibits viral polyprotein processing, thereby preventing viral replication. Pomotrelvir has shown broad antiviral activity against multiple SARS-CoV-2 variants (including Omicron) in cell-based experiments, and has an additive effect when combined with nucleoside analogs that target viral RNA synthesis. Pomotrelvir is primarily used for the research and development of COVID-19 antiviral drugs, especially for infections caused by SARS-CoV-2 and its variants .
Cat. No.: HY-19476
CAS No.: 343565-99-1
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AG-7404 is an orally active, irreversible inhibitor of the picornavirus 3C protease. AG-7404 blocks the processing of viral polyproteins, thereby inhibiting viral replication. AG-7404 has synergistic antiviral activity with capsid inhibitors such as V-073 (HY-104074) or BTA798 (HY-106254) and is effective against V-073-resistant variants. AG-7404 is used in the study of enterovirus infections such as poliovirus .
Cat. No.: HY-78726S
CAS No.: 1133702-41-6
Synonyms: Amprenavir phosphate-d4; GW 433908-d4
Cat. No.: HY-105148
CAS No.: 174391-92-5
Synonyms: DMP-450
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Mozenavir (DMP 450) is an orally active and highly selective inhibitor of HIV-1 protease (Ki=0.3 nM). Mozenavir blocks the cleavage and processing of viral polyproteins, inhibiting the replication and maturation of HIV-1. Mozenavir is promising for research of HIV infection .
Cat. No.: HY-N144101
CAS No.: 81418-42-0
Category:
Infection Quinones Plants Lithospermum canescens Lehm. Disease Research Fields Boraginaceae Naphthalene Quinones
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Cat. No.: HY-78726A
CAS No.: 226700-80-7
Synonyms: Amprenavir phosphate sodium; GW 433908 sodium
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Research Areas:
Fosamprenavir sodium is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir sodium is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir sodium can be used for the study of human immunodeficiency virus (HIV-1) infection .
Cat. No.: HY-78726S2
Synonyms: Amprenavir phosphate-13C6; GW 433908-13C6
Cat. No.: HY-17431R
CAS No.: 226700-81-8
Synonyms: GW433908G (Standard)
Category:
Cat. No.: HY-P5415
CAS No.: 127134-13-8
Cat. No.: HY-184048
CAS No.: 33580-97-1
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JMX0207 is an orally active flavivirus NS2B-NS3 protease inhibitor. JMX0207 showed an IC50-SLC of 1.3 μM for blocking NS2B-NS3 protein interaction and an IC50-pro of 8.2 μM for inhibiting protease catalytic activity.. JMX0207 directly binds viral NS3 protease at the NS2B-NS3 interface with a Kd of 1.1 μM, blocks viral polyprotein precursor processing, suppresses viral RNA replication and viral protein production. JMX0207 can be used for the study of Zika virus infection and Dengue virus infection .
Cat. No.: HY-126120
CAS No.: 154612-31-4
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BILA 1906 BS is a HIV protease inhibitor. BILA 1906 BS prevents HIV-1 replication via inhibition of viral protease-mediated cleavage of Gag and Gag-Pol polyprotein precursors during virion maturation. BILA 1906 BS blocks maturation of p24 proteins in wild-type HIV-1, impairing polyprotein processing and viral maturation. BILA 1906 BS can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection .
Cat. No.: HY-181983
CAS No.: 2759276-10-1
VPC285785 is an orally active SARS-CoV-2 main protease inhibitor with an IC50 of 0.8 μM and a Kd of 2.7 μM. VPC285785 functionally inhibits the viral main protease-mediated processing of viral polyprotein precursors required for viral replication. VPC285785 reduces viral loads in the liver, brain and spleen tissues of MHV-infected mice. VPC285785 is applicable to the research of coronavirus infections .
Cat. No.: HY-184733
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SARS-CoV-2 Mpro-IN-60 is a SARS-CoV-2 M pro inhibitor with an IC50 of 0.031 μM. SARS-CoV-2 Mpro-IN-60 is applicable to the research of COVID-19 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
