1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. SHP2-IN-9

SHP2-IN-9 

Cat. No.: HY-115925
Handling Instructions

SHP2-IN-9 is a specific SHP2 inhibitor (IC50 =1.174 μM) with enhanced blood–brain barrier penetration. SHP2-IN-9 shows 85-fold more selective for SHP2 than SHP1. SHP2-IN-9 inhibits SHP2-mediated cell signal transduction and cancer cell proliferation, and inhibits the growth of cervix cancer tumors and glioblastoma growth in vivo.

For research use only. We do not sell to patients.

SHP2-IN-9 Chemical Structure

SHP2-IN-9 Chemical Structure

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Description

SHP2-IN-9 is a specific SHP2 inhibitor (IC50 =1.174 μM) with enhanced blood–brain barrier penetration. SHP2-IN-9 shows 85-fold more selective for SHP2 than SHP1. SHP2-IN-9 inhibits SHP2-mediated cell signal transduction and cancer cell proliferation, and inhibits the growth of cervix cancer tumors and glioblastoma growth in vivo[1].

In Vitro

SHP2-IN-9 (compound 2) could effectively inhibit SHP2-mediated cell signaling pathways in cancer (cervix cancer, human pancreatic cancer, large cell lung cancer and mouse glioma cell) by inhibiting the phosphorylation of Paxillin, affecting the regulation of the PI3K/AKT pathway and cell proliferation by causing the cell cycle arrest and inducing the early apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

385.46

Formula

C20H20FN3O2S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SHP2-IN-9
Cat. No.:
HY-115925
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