1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. SHP836

SHP836 

Cat. No.: HY-121879 Purity: 99.59%
Handling Instructions

SHP836 is a SHP2 allosteric inhibitor, with an IC50 of 12 μM for the full length SHP2.

For research use only. We do not sell to patients.

SHP836 Chemical Structure

SHP836 Chemical Structure

CAS No. : 1957276-35-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 700 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

SHP836 is a SHP2 allosteric inhibitor, with an IC50 of 12 μM for the full length SHP2[1].

IC50 & Target

IC50: 12 μM (SHP2)[1]

In Vitro

SHP836 stabilizes the active conformation of SHP2, in which the catalytic site is blocked and no longer accessible to substrate[1].

Molecular Weight

352.26

Formula

C₁₆H₁₉Cl₂N₅

CAS No.

1957276-35-5

SMILES

NC1=NC(N2C[[email protected]@H](C)N[[email protected]@H](C)C2)=NC=C1C3=CC=CC(Cl)=C3Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (709.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8388 mL 14.1941 mL 28.3881 mL
5 mM 0.5678 mL 2.8388 mL 5.6776 mL
10 mM 0.2839 mL 1.4194 mL 2.8388 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (17.74 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (17.74 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (17.74 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SHP836SHP 836SHP-836PhosphataseSHP2allostericinhibitorInhibitorinhibit

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Product Name:
SHP836
Cat. No.:
HY-121879
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