STARD3-IN-1
Based on 1 Customer Validation
STARD3-IN-1 (Compound VS1) is a STARD3 inhibitor with an IC₅₀ of 35 μM. STARD3 is a protein that is overexpressed in various cancers and is involved in cholesterol transport. STARD3-IN-1 exhibits anti-proliferative activity in breast cancer and colon cancer cells, significantly weakening the clonogenic ability of cancer cells. STARD3-IN-1 increases the protein levels of FAK and pTyr397-FAK. STARD3-IN-1 can be used for research on breast cancer and colon cancer.
For research use only. We do not sell to patients.
- Purity: 99.02%
- CAS No.: 1424357-72-1
- Formula: C22H20N4O4
- Molecular Weight:404.42
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
70.7 μM
Compound: VS1
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Antiproliferative activity against human HCT116 cells after 96 hrs by Cell Titer-Glo based luminescence assay
Antiproliferative activity against human HCT116 cells after 96 hrs by Cell Titer-Glo based luminescence assay
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[PMID: 30996782] |
| MCF7 | IC50 |
105.5 μM
Compound: VS1
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Antiproliferative activity against human MCF7 cells after 96 hrs by Cell Titer-Glo based luminescence assay
Antiproliferative activity against human MCF7 cells after 96 hrs by Cell Titer-Glo based luminescence assay
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[PMID: 30996782] |
| MDA-MB-231 | IC50 |
49.7 μM
Compound: VS1
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Antiproliferative activity against human MDA-MB-231 after 96 hrs by Cell Titer-Glo based luminescence assay
Antiproliferative activity against human MDA-MB-231 after 96 hrs by Cell Titer-Glo based luminescence assay
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[PMID: 30996782] |
Chemical Information
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CAS No. 1424357-72-1
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Appearance Powder
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Molecular Weight 404.42
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Formula C22H20N4O4
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Color Orange to red
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SMILES
O=C(NC(/C=C/C1=CC([N+]([O-])=O)=C(O)C=C1)=N2)C3=C2CN(CC4=CC=CC=C4)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 5 mg/mL (12.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4727 mL | 12.3634 mL | 24.7268 mL | 61.8169 mL |
| 5 mM | 0.4945 mL | 2.4727 mL | 4.9454 mL | 12.3634 mL | |
| 10 mM | 0.2473 mL | 1.2363 mL | 2.4727 mL | 6.1817 mL |
STARD3-IN-1 Related Classifications
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