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Cat. No.: HY-144870

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STAT3-IN-7

STAT3-IN-7, an aryl sulfonamido azetidine compound, is an orally active STAT3 inhibitor. STAT3-IN-7 has anticancer activities (WO2021016333A1, H182).

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CAS No.: 2237955-91-6
Formule: C₃₀H₂₆F₅N₅O₄S
Masse moléculaire:647.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

STAT3-IN-7 Chemical Structure

CAS No.: 2237955-91-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

STAT3-IN-7, an aryl sulfonamido azetidine compound, is an orally active STAT3 inhibitor. STAT3-IN-7 has anticancer activities (WO2021016333A1, H182)^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	EC₅₀	4 μM Compound: 9f	Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay	[PMID: 33352047]
MCF7	EC₅₀	3.6 μM Compound: 9f	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay	[PMID: 33352047]
MDA-MB-231	EC₅₀	3.3 μM Compound: 9f	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay	[PMID: 33352047]
MDA-MB-468	EC₅₀	1.5 μM Compound: 9f	Antiproliferative activity against human MDA-MB-468 cells harbouring STAT3 assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay Antiproliferative activity against human MDA-MB-468 cells harbouring STAT3 assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay	[PMID: 33352047]

Chemical Information

CAS No. 2237955-91-6
Masse moléculaire 647.62
Formule C₃₀H₂₆F₅N₅O₄S
SMILES

O=C1NC=NC2=C1C=CC(N(C([C@H]3CCN3S(=O)(C4=C(C(F)=C(C(F)=C4F)F)F)=O)=O)CC5=CC=C(C=N5)C6CCCCC6)=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. James Turkson, et al. Aryl sulfonamides as small molecule stat3 inhibitors. WO2021016333A1.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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