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Cat. No.: HY-W1063573

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STAT6 ligand-3

STAT6 ligand-3 (Compound 15) is a heterocyclic indole carboxamide STAT6 binding ligand. STAT6 ligand-3 can be used to synthesize PROTAC products, such as PROTAC STAT6 degrader-13 (HY-188369).

For research use only. We do not sell to patients.

CAS No.: 3077376-96-3
Formula: C₂₂H₂₃ClFN₅O₂
Molecular Weight:443.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

STAT6 ligand-3 Chemical Structure

CAS No.: 3077376-96-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

STAT6 ligand-3 (Compound 15) is a heterocyclic indole carboxamide STAT6 binding ligand. STAT6 ligand-3 can be used to synthesize PROTAC products, such as PROTAC STAT6 degrader-13 (HY-188369)^[1].

IC₅₀ & Target

^[1]

STAT6

All STAT Isoforms :

In Vitro

PROTAC stands for proteolysis-targeting chimeras, a type of heterobifunctional small-molecule compound whose structure contains two different ligands: one is a ubiquitin ligase E3 ligand, and the other is a ligand that binds to the target protein in cells. The two ligands are connected by a linker, thereby forming a "three-body" polymer-target protein ligand-Linker-E3 ligand. PROTACs specifically degrade target proteins through the "ubiquitin-proteasome" pathway by bringing the target protein and the intracellular E3 ubiquitin ligase into closer proximity. PROTACs can improve the druggability of "undruggable" targets.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3077376-96-3
Molecular Weight 443.90
Formula C₂₂H₂₃ClFN₅O₂
SMILES

O=C(N1CC(C2=C(F)C3=C(C=C(C(N(C)C)=O)N3)C(Cl)=C2)=CCC1)CCN4C=CC=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang W, et al. Discovery of a Potent, Selective, and Orally Efficacious STAT6 PROTAC for the Treatment of Atopic Dermatitis. J Med Chem. 2026 Oct 8;69(19):22102-22137.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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STAT6 ligand-3

All STAT Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

STAT6 ligand-3 Related Classifications

HY-W1063573 Related Classifications

Bioz

Keywords

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