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Cat. No.: HY-164109

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Tafuramycin A

Tafuramycin A, a Duocarmycin derivative, is a potent anticancer and parasite attenuating agent. Tafuramycin A can be used for triple-negative breast cancer (TNBC) and malaria infection research.

For research use only. We do not sell to patients.

CAS No.: 494868-78-9
Formula: C₂₃H₂₁ClN₂O₆
Molecular Weight:456.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Tafuramycin A Chemical Structure

CAS No.: 494868-78-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Tafuramycin A, a Duocarmycin derivative, is a potent anticancer and parasite attenuating agent. Tafuramycin A can be used for triple-negative breast cancer (TNBC) and malaria infection research^[1]^[2].

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.7 nM Compound: 3	Cytotoxicity against human A549 cells after 4 days by MTT assay Cytotoxicity against human A549 cells after 4 days by MTT assay	[PMID: 29548574]
A549	IC₅₀	53 nM Compound: 3	Cytotoxicity against human A549 cells after 3 days by MTT assay Cytotoxicity against human A549 cells after 3 days by MTT assay	[PMID: 29548574]
B16	IC₅₀	40 nM Compound: 3	Cytotoxicity against mouse B16 cells after 3 days by MTT assay Cytotoxicity against mouse B16 cells after 3 days by MTT assay	[PMID: 29548574]

Chemical Information

CAS No. 494868-78-9
Molecular Weight 456.88
Formula C₂₃H₂₁ClN₂O₆
SMILES

O=C(N1C2=C(C(C1)CCl)C3=C(C=CO3)C(O)=C2)C4=CC5=C(N4)C(OC)=C(OC)C(OC)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. El-Deeb IM, et al. Selective Targeting of Breast Cancer by Tafuramycin A Using SMA-Nanoassemblies. Molecules. 2021 Jun 9;26(12):3532. [Content Brief]

[2]. El-Deeb IM, et al. A versatile synthesis of "tafuramycin A": a potent anticancer and parasite attenuating agent. Org Biomol Chem. 2014 Jun 28;12(24):4260-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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Tafuramycin A

All Parasite Isoforms