2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. Tedalinab

Tedalinab  (Synonyms: GRC-10693)

Cat. No.: HY-14900 Purity: 99.94%
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Tedalinab (GRC-10693) is a potent, orally active, and selective cannabinoid receptor 2 (CB2) agonist. Tedalinab has >4700-fold functional selectivity for CB2 over CB1. Tedalinab has potential for neuropathic pain and osteoarthritis treatment.

For research use only. We do not sell to patients.

Tedalinab Chemical Structure

Tedalinab Chemical Structure

CAS No. : 916591-01-0

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 418 In-stock
Solution
10 mM * 1 mL in DMSO USD 418 In-stock
Solid
5 mg USD 380 In-stock
10 mg USD 600 In-stock
25 mg USD 1150 In-stock
50 mg USD 1800 In-stock
100 mg USD 2850 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Tedalinab Related Antibodies

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Description

Tedalinab (GRC-10693) is a potent, orally active, and selective cannabinoid receptor 2 (CB2) agonist. Tedalinab has >4700-fold functional selectivity for CB2 over CB1. Tedalinab has potential for neuropathic pain and osteoarthritis treatment[1].

IC50 & Target[1]

CB2

 

Molecular Weight

345.39

Formula

C19H21F2N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN(C2=CC=C(F)C=C2F)C3=C1[C@@]4([H])CC[C@]3([H])C4)NC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (289.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8953 mL 14.4764 mL 28.9528 mL
5 mM 0.5791 mL 2.8953 mL 5.7906 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8953 mL 14.4764 mL 28.9528 mL 72.3819 mL
5 mM 0.5791 mL 2.8953 mL 5.7906 mL 14.4764 mL
10 mM 0.2895 mL 1.4476 mL 2.8953 mL 7.2382 mL
15 mM 0.1930 mL 0.9651 mL 1.9302 mL 4.8255 mL
20 mM 0.1448 mL 0.7238 mL 1.4476 mL 3.6191 mL
25 mM 0.1158 mL 0.5791 mL 1.1581 mL 2.8953 mL
30 mM 0.0965 mL 0.4825 mL 0.9651 mL 2.4127 mL
40 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.8095 mL
50 mM 0.0579 mL 0.2895 mL 0.5791 mL 1.4476 mL
60 mM 0.0483 mL 0.2413 mL 0.4825 mL 1.2064 mL
80 mM 0.0362 mL 0.1810 mL 0.3619 mL 0.9048 mL
100 mM 0.0290 mL 0.1448 mL 0.2895 mL 0.7238 mL
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Tedalinab Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tedalinab916591-01-0GRC-10693GRC10693GRC 10693Cannabinoid ReceptorneuropathicpainosteoarthritisselectiveoralbioavailabilityInhibitorinhibitorinhibit

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