2. PROTAC
  3. PROTAC Linkers
  4. Thiol-PEG4-acid

Thiol-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Thiol-PEG4-acid Chemical Structure

Thiol-PEG4-acid Chemical Structure

CAS No. : 749247-06-1

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50 mg USD 70 In-stock
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Based on 1 publication(s) in Google Scholar

Thiol-PEG4-acid Related Antibodies

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Description

Thiol-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thiol-PEG4-acid Related Antibodies
Molecular Weight

282.35

Formula

C11H22O6S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCOCCOCCS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (354.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5417 mL 17.7085 mL 35.4170 mL
5 mM 0.7083 mL 3.5417 mL 7.0834 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5417 mL 17.7085 mL 35.4170 mL 88.5426 mL
5 mM 0.7083 mL 3.5417 mL 7.0834 mL 17.7085 mL
10 mM 0.3542 mL 1.7709 mL 3.5417 mL 8.8543 mL
15 mM 0.2361 mL 1.1806 mL 2.3611 mL 5.9028 mL
20 mM 0.1771 mL 0.8854 mL 1.7709 mL 4.4271 mL
25 mM 0.1417 mL 0.7083 mL 1.4167 mL 3.5417 mL
30 mM 0.1181 mL 0.5903 mL 1.1806 mL 2.9514 mL
40 mM 0.0885 mL 0.4427 mL 0.8854 mL 2.2136 mL
50 mM 0.0708 mL 0.3542 mL 0.7083 mL 1.7709 mL
60 mM 0.0590 mL 0.2951 mL 0.5903 mL 1.4757 mL
80 mM 0.0443 mL 0.2214 mL 0.4427 mL 1.1068 mL
100 mM 0.0354 mL 0.1771 mL 0.3542 mL 0.8854 mL
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Thiol-PEG4-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiol-PEG4-acid749247-06-1PROTAC LinkersInhibitorinhibitorinhibit

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