TLR7 agonist 17
TLR7 agonist 17 (compound 20) is a potent TLR7 agonist with EC50 values of 12 nM and 17 nM for hTLR7 and mTLR7, respectively. TLR7 agonist 17 shows anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 2410517-32-5
- Formula: C25H37N7O3
- Molecular Weight:483.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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human TLR7 12 nM (EC50) |
mTLR7 17 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T-cell | IC50 |
>25 μM
Compound: 20
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Cytotoxicity against PHA-activated T cells (unknown origin) assessed as inhibition of IL-2 induced cell proliferation by PHA-blast assay
Cytotoxicity against PHA-activated T cells (unknown origin) assessed as inhibition of IL-2 induced cell proliferation by PHA-blast assay
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[PMID: 38352830] |
Chemical Information
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CAS No. 2410517-32-5
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Molecular Weight 483.61
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Formula C25H37N7O3
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SMILES
NC1=NC(N[C@H](CCO)CCC)=C(N(CC2=C(OC)C=C(CNC3CCOCC3)C=C2)N=C4)C4=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TLR7 agonist 17 Related Classifications
HY-162115 Related Classifications
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