TLR7 agonist 17
TLR7 agonist 17 (compound 20) is a potent TLR7 agonist with EC50 values of 12 nM and 17 nM for hTLR7 and mTLR7, respectively. TLR7 agonist 17 shows anticancer activity.
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- No. CAS: 2410517-32-5
- Fòrmula: C25H37N7O3
- Peso molecular:483.61
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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human TLR7 12 nM (EC50) |
mTLR7 17 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T-cell | IC50 |
>25 μM
Compound: 20
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Cytotoxicity against PHA-activated T cells (unknown origin) assessed as inhibition of IL-2 induced cell proliferation by PHA-blast assay
Cytotoxicity against PHA-activated T cells (unknown origin) assessed as inhibition of IL-2 induced cell proliferation by PHA-blast assay
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[PMID: 38352830] |
Chemical Information
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No. CAS 2410517-32-5
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Peso molecular 483.61
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Fòrmula C25H37N7O3
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SMILES
NC1=NC(N[C@H](CCO)CCC)=C(N(CC2=C(OC)C=C(CNC3CCOCC3)C=C2)N=C4)C4=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TLR7 agonist 17 Related Classifications
HY-162115 Related Classifications
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