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Cat. No.: HY-181763

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Tubulin-IN-65

Tubulin-IN-65 (Compound Imp-18) is a Tubulin inhibitor. Tubulin-IN-65 exhibits tubulin-disrupting activity. Tubulin-IN-65 disrupts microtubule integrity. Tubulin-IN-65 induces Apoptosis and increases the expression of CDK1 and Cyclin B1. Tubulin-IN-65 possesses anticancer activity against breast cancer and colorectal cancer. Tubulin-IN-65 can be used in research related to triple-negative breast cancer and colorectal adenocarcinoma.

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화학식: C₂₅H₁₇N₃O
분자량:375.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Tubulin-IN-65 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

CDK1

All CDK Isoforms :

In Vitro

Tubulin-IN-65 (0.1-80 μM; 72 h) potently inhibits the viability of MDA-MB-231 and DLD-1 cancer cells, with IC₅₀ values of 0.22 μM and 0.84 μM against the two cell lines, respectively. Meanwhile, this compound exhibits cancer cell specificity, with a selectivity index of 4.1 relative to the non-tumorigenic MCF-10A cells^[1].
Tubulin-IN-65 (48 h) effectively induces apoptosis in MDA-MB-231 and DLD-1 cancer cells^[1].
Tubulin-IN-65 (48 h) disrupts cell cycle progression in MDA-MB-231 and DLD-1 cancer cells, induces accumulation of apoptotic cells in the Sub-G1 phase, causes G1/G0 phase arrest and alters G2/M phase distribution, with no effect on the S phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 375.42
화학식 C₂₅H₁₇N₃O
SMILES

CC(C=C1)=CC2=C1OC(C3=C(N=C4N3C=CC=C4)C5=CC(C=CC=C6)=C6C=C5)=N2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kuzu B, et al. Strategic engineering of imidazopyridine-benzoxazole hybrids targeting microtubule dynamics: comprehensive inhibition of the metastatic cascade. Bioorg Chem. 2026;172:109615. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
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Purity:
수량:

Tubulin-IN-65

All CDK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Tubulin-IN-65 Related Classifications

HY-181763 Related Classifications