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Cat. No.: HY-101008

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3-MPPI

3-MPPI is a GPCR ligand with high selectivity for α₁-adrenergic receptor, with a K_i value of 0.21 nM for α₁-adrenergic receptor and 50 nM for 5-HT₁A receptor. 3-MPPI modulates the α₁-adrenergic receptor signaling cascade. 3-MPPI is applicable to research related to hypertension, stress-induced anxiety-like behavioral responses, and levodopa-induced dyskinesia.

For research use only. We do not sell to patients.

CAS No.: 133399-65-2
Formula: C₂₃H₂₅N₅O₃
Molecular Weight:419.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

3-MPPI Chemical Structure

CAS No.: 133399-65-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Adrenergic Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	Inhibition	9.14 % Compound: 3-MPPI	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	10.21203/rs.3.rs-23951/v1

In Vitro

3-MPPI (compound RN5) derivatives exhibit exceptional α₁-adrenoceptor (α₁-AR) affinity (K_i = 2.71 nM) and selectivity over 5-HT₁A receptors (5-HT₁A/α₁ ratio > 3500)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 133399-65-2
Molecular Weight 419.49
Formula C₂₃H₂₅N₅O₃
SMILES

O=C1NC=2C=3C=CC=CC3NC2C(=O)N1CCN4CCN(C=5C=CC=CC5OC)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pittalà V, et al. Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors. Bioorg Med Chem. 2011 Sep 1;19(17):5260-76. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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