Cat. No.: HY-W013049

Docosanoic acid

(Synonyms: Behenic acid)

Customer Review

Based on 1 Customer Validation

Docosanoic acid (Behenic acid) is a long-chain saturated fatty acid. Docosanoic acid inhibits the double-stranded DNA (dsDNA) binding activity of p53 DNA binding domain, with a K_d of 12 nM. Docosanoic acid has low bioavailability and can increase cholesterol in humans.

For research use only. We do not sell to patients.

Purity: 99.40%
CAS No.: 112-85-6
Formula: C₂₂H₄₄O₂
Molecular Weight:340.59

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Docosanoic acid Chemical Structure

CAS No.: 112-85-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

All DNA/RNA Synthesis Isoforms :

In Vitro

Docosanoic acid is effective at inhibiting the dsDNA binding activity of wild-type p53 DBD, with 50% inhibition observed at 0.41 nmol. The inhibitory effect of Docosanoic acid on the activities of R248A mutant p53 DBD was almost as strong as that of the wild-type^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In rats, the percentage of Behenic acid in the diet is 1.7% and shows a significant reduction in the deposition of visceral fat, confirmed by a lower weight of adipose (epididymal and mesenteric) and hepatic tissues, as well as excreting more fatty acids in the feces when compared to the group. Behenic acid has a low bioavailability, which leads to a reduction in the absorption and as a consequence, to the reduction in body weight and deposition of visceral fat^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 112-85-6
Appearance Solid
Molecular Weight 340.59
Formula C₂₂H₄₄O₂
Color Off-white to light yellow
SMILES

CCCCCCCCCCCCCCCCCCCCCC(O)=O
Synonyms

Behenic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMF : 9.09 mg/mL (26.69 mM; ultrasonic and warming and heat to 60°C)

DMSO : 1 mg/mL (2.94 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9361 mL

14.6804 mL

29.3608 mL

5 mM

0.5872 mL

2.9361 mL

5.8722 mL

10 mM

0.2936 mL

1.4680 mL

2.9361 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

Dilution Calculator

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 3.33 mg/mL (9.78 mM); Suspended solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cater NB, et al. Behenic acid is a cholesterol-raising saturated fatty acid in humans. Am J Clin Nutr. 2001 Jan;73(1):41-4. [Content Brief]

[2]. Moreira DK, et al. Evaluation of structured lipids with behenic acid in the prevention of obesity. Food Res Int. 2017 May;95:52-58. [Content Brief]

[3]. Iijima H, et al. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. Lipids. 2006 Jun;41(6):521-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / DMF	1 mM	2.9361 mL	14.6804 mL	29.3608 mL	73.4020 mL
DMF	5 mM	0.5872 mL	2.9361 mL	5.8722 mL	14.6804 mL
	10 mM	0.2936 mL	1.4680 mL	2.9361 mL	7.3402 mL
	15 mM	0.1957 mL	0.9787 mL	1.9574 mL	4.8935 mL
	20 mM	0.1468 mL	0.7340 mL	1.4680 mL	3.6701 mL
	25 mM	0.1174 mL	0.5872 mL	1.1744 mL	2.9361 mL

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Docosanoic acid

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All Endogenous Metabolite Isoforms

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Docosanoic acid Related Classifications

HY-W013049 Related Classifications