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Cat. No.: HY-N3509

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Hyponine E

(Synonyms: (-)-Hyponine E)

Hyponine E, a macrocyclic sesquiterpene pyridine alkaloid that could be isolated from from Tripterygium hypoglaucum, possesses anti-inflammatory effects.

For research use only. We do not sell to patients.

CAS No.: 226975-99-1
Formula: C₄₅H₄₈N₂O₁₉
Molecular Weight:920.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Hyponine E Chemical Structure

CAS No.: 226975-99-1

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Hyponine E, a macrocyclic sesquiterpene pyridine alkaloid that could be isolated from from Tripterygium hypoglaucum, possesses anti-inflammatory effects^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
H9	EC₅₀	0.17 μg/mL Compound: 11	Antiviral activity against HIV1 in human H9 cells assessed as inhibition of viral replication Antiviral activity against HIV1 in human H9 cells assessed as inhibition of viral replication	[PMID: 10757718]
H9	IC₅₀	1.95 μg/mL Compound: 11	Cytotoxicity against human H9 cells Cytotoxicity against human H9 cells	[PMID: 10757718]

Chemical Information

CAS No. 226975-99-1
Molecular Weight 920.86
Formula C₄₅H₄₈N₂O₁₉
SMILES

CC1C(C)C(O[C@H]2[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]3(COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C4=CN=CC=C4)=O)[C@@H]5[C@@H](OC(C6=CC=CO6)=O)[C@]3(O[C@@]5(C)COC(C7=C1N=CC=C7)=O)[C@]2(O)C)=O
Synonyms

(-)-Hyponine E
Structure Classification
- Alkaloids
- Pyridine Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. HongquanDuan, et al. Sesquiterpene evoninate alkaloids from Tripterygium hypoglaucum. Phytochemistry Volume 52, Issue 8, December 1999, Pages 1735-1738.

[2]. Mei Xue, et al. Anti-inflammatory effects and hepatotoxicity of Tripterygium-loaded solid lipid nanoparticles on adjuvant-induced arthritis in rats. Phytomedicine. 2012 Aug 15;19(11):998-1006. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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