Kievitone
Based on 1 Customer Validation
Kievitone, an isoflavanone, could be isolated from hypocotyls of Phaseolus vulgaris L. infected with Rhizoctonia solani Kühn. Kievitone has antifungal activity and antitumor activity.
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 40105-60-0
- Formula: C20H20O6
- Molecular Weight:356.37
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Kievitone (0-40 μM; 4 days) inhibits the proliferation of the oestrogen receptor (ER)-positive breast cancer cell lines MCF-7 and T47D and the ER-negative breast cancer cell line SKBR3 (IC50 values 5-18 μM)[2].
Kievitone (0-40 μM; 48 h) inhibits DNA synthesis of MCF-7 cells stimicrolated by insulin-like growth factor 1, insulin-like growth factor 2, basic fibroblast growth factor or transforming growth factor α[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, T47D and SKBR3 cells
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Concentration:0-40 μM
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Incubation Time:4 days
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Result:Inhibited breast cancer cell proliferation in a dose-dependent manner.
Chemical Information
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CAS No. 40105-60-0
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Appearance Solid
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Molecular Weight 356.37
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Formula C20H20O6
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Color White to off-white
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SMILES
O=C1C(COC2=C(C(O)=CC(O)=C12)C/C=C(C)\C)C3=CC=C(C=C3O)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (280.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8061 mL | 14.0304 mL | 28.0607 mL | 70.1518 mL |
| 5 mM | 0.5612 mL | 2.8061 mL | 5.6121 mL | 14.0304 mL | |
| 10 mM | 0.2806 mL | 1.4030 mL | 2.8061 mL | 7.0152 mL | |
| 15 mM | 0.1871 mL | 0.9354 mL | 1.8707 mL | 4.6768 mL | |
| 20 mM | 0.1403 mL | 0.7015 mL | 1.4030 mL | 3.5076 mL | |
| 25 mM | 0.1122 mL | 0.5612 mL | 1.1224 mL | 2.8061 mL | |
| 30 mM | 0.0935 mL | 0.4677 mL | 0.9354 mL | 2.3384 mL | |
| 40 mM | 0.0702 mL | 0.3508 mL | 0.7015 mL | 1.7538 mL | |
| 50 mM | 0.0561 mL | 0.2806 mL | 0.5612 mL | 1.4030 mL | |
| 60 mM | 0.0468 mL | 0.2338 mL | 0.4677 mL | 1.1692 mL | |
| 80 mM | 0.0351 mL | 0.1754 mL | 0.3508 mL | 0.8769 mL | |
| 100 mM | 0.0281 mL | 0.1403 mL | 0.2806 mL | 0.7015 mL |
Kievitone Related Classifications
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