TP0427736
Based on 2 publication(s) in Google Scholar
TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells.
For research use only. We do not sell to patients.
- CAS No.: 864374-00-5
- Formula: C14H10N4S2
- Molecular Weight:298.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) TP0427736
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| A549 | IC50 |
8.7 nM
Compound: 3a
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Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 hr by fluorescence analysis
Inhibition of ALK5-mediated TNFalpha-induced Smad2/3 phosphorylation in human A549 cells preincubated for 2 hrs before addition of TNFalpha after 1 hr by fluorescence analysis
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[PMID: 23117174] |
Chemical Information
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CAS No. 864374-00-5
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Molecular Weight 298.39
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Formula C14H10N4S2
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SMILES
CC1=CSC(C2=C(NC=N2)C3=CC=C4N=CSC4=C3)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Clin Invest
Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communications. [Abstract]2024 Jun 18;134(16):e178303. PMID: 38889010 -
Commun Biol
Wnt11 mediates fibroblast-smooth muscle cell interaction to promote neurogenic bladder fibrosis in rats. [Abstract]2026 Feb 9;9(1):194. PMID: 41663583
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)