Uliledlimab
Based on 1 Customer Validation
Uliledlimab is a potent against CD73 humanizedized monoclonal antibody. Uliledlimab inhibits the conversion of extracellular adenosine monophosphate (AMP) to adenosine. Uliledlimab can be used in research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.35%
- CAS No.: 2378407-27-1
- Molecular Weight:145.04 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
NT5E/CD73
Uliledlimab binds to the CD73 protein through a C-terminal domain binding mode, thereby completely inhibiting the enzymatic activity of CD73. Uliledlimab relieves the inhibition of immune cells and enhances the activity of CD8+ T cells and macrophages by blocking the production of adenosine, thereby improving anti-tumor immune response[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized CD73/5'-Nucleotidase Protein, Human can bind Uliledlimab. The EC50 for this effect is 2.1 ng/mL. -
Flow Cytometry analysis of A431 cells labelling NT5E/CD73 (red) with Uliledlimab (anti-NT5E/CD73) (HY-P99169). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 2378407-27-1
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Appearance Liquid
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Molecular Weight 145.04 kDa
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Color Colorless to light yellow
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SMILES
[Uliledlimab]
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Synonyms
TJ004309
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)